• 수산해양기술연구
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• 제51권2호
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• pp.155-162
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• 2015

Abalone (Haliotis discus hannai) is a shellfish that feeds on kelp and, as a product, it can often achieve a high market value. However, the dissolved oxygen (DO) levels in coastal waters in Korea have been negatively impacted by pollution from many anthropogenic sources. Herein, a computational fluid dynamics (CFD) software package was used to analyze the distribution of the DO concentration within an abalone containment structure. A finite volume approach was used to solve the Reynolds-averaged Navier-Stokes equations combined with a $k-{\varepsilon}$ turbulence model to describe the flow. The distribution of DO was determined within the control volume domain, and the transport equations of the pollutants were interpreted using a CFD model. The CFD analysis revealed that more than 60% and 30% of the relative oxygen concentration in one and two containers, respectively, was maintained when the flow acts along the six sheets of polyethylene plates. Therefore, it is clear that the abalone plate shelters should be placed parallel to the flow.

• 제어로봇시스템학회논문지
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• 제14권5호
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• pp.415-419
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• 2008

Detecting and correcting defects on LCD glasses early in the manufacturing process becomes important for panel makers to reduce the manufacturing costs and to improve productivity. Many attempts have been made and were successfully applied to detect and identify simple defects such as scratches, dents, and foreign objects on glasses. However, it is still difficult to robustly detect low-contrast defect region, called Mura or blemish area on glasses. Typically, these defect areas are roughly defined as relatively large, several millimeters of diameter, and relatively dark and/or bright region of low Signal-to-Noise Ratio (SNR) against background of low-frequency signal. The aim of this article is to present a robust algorithm to segment these blemish defects. Early 90's, a highly robust estimator, known as the Model-Fitting (MF) estimator was developed by X. Zhuang et. al. and have been successfully used in many computer vision application. Compared to the conventional Least-Square (LS) estimator the MF estimator can successfully estimate model parameters from a dataset of contaminated Gaussian mixture. Such a noise model is defined as a regular white Gaussian noise model with probability $1-\varepsilon$ plus an outlier process with probability $varepsilon$. In the sense of robust estimation, the blemish defect in images can be considered as being a group of outliers in the process of estimating image background model parameters. The algorithm developed in this paper uses a modified MF estimator to robustly estimate the background model and as a by-product to segment the blemish defects, the outliers.

• Industrial Engineering and Management Systems
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• 제13권1호
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• pp.52-66
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• 2014

Promotion of a closed-loop supply chain requires disassembly systems that recycle end-of-life (EOL) assembled products. To operate the recycling disassembly system, parts selection is environmentally and economically carried out with non-destructive or destructive disassembly, and the recycling rate of the whole EOL product is determined. As the number of disassembled parts increases, the recycling rate basically increases. However, the labor cost also increases and brings lower profit, which is the difference between the recovered material prices and the disassembly costs. On the other hand, since the precedence relationships among disassembly tasks of the product also change with the parts selections, it is also required to optimize allocation of the tasks in designing a disassembly line. In addition, because information is required for such a design, the recycling rate, profit of each part and disassembly task times take precedence among the disassembly tasks. However, it is difficult to obtain that information in advance before collecting the actual EOL product. This study proposes and analyzes an optimal disassembly system design using integer programming with the environmental and economic parts selection (Igarashi et al., 2013), which harmonizes the recycling rate and profit using recyclability evaluation method (REM) developed by Hitachi, Ltd. The first stage involves optimization of environmental and economic parts selection with integer programming with ${\varepsilon}$ constraint, and the second stage involves optimization of the line balancing with integer programming in terms of minimizing the number of stations. The first and second stages are generally and mathematically formulized, and the relationships between them are analyzed in the cases of cell phones, computers and cleaners.

• 생명과학회지
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• 제19권12호
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• pp.1808-1814
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• 2009

방사선에 대한 방호와 면역기능 조절을 목적으로 새로운 생약복합조성물인 HemoHIM을 개발하였다. 식품 원료로 사용 가능한 생약재 3종 당귀, 천궁, 백작약의 에탄올 분획을 열수추출물에 첨가하여 HemoHIM을 제조하였다. HemoHIM의 항알레르기 효과를 검증하기 위하여 사람 비만세포주 HMC-1을 사용해 compound 48/80으로 유도되는 히스타민 분비량과 PMA/A23187로 유도되는 염증성 사이토카인의 분비량을 측정하였다. 히스타민의 양은 형광분석법으로, 염증성 사이토카인 IL-6, IL-8, TNF-$\alpha$, GM-CSF의 양은 효소결합 면역측정법으로 측정하였다. 저농도의 HemoHIM에 의해 히스타민 분비량이 억제되었고, 모든 농도에서 IL-6, TNF-$\alpha$, GM-CSF의 분비량은 억제되었지만 IL-8은 고농도에서만 억제되었다. 사이토카인의 mRNA 발현량은 HemoHIM의 농도 의존적으로 억제되었다. 그리고 c-kit와 Fc$\varepsilon$RI의 mRNA 발현량도 모든 농도에서 억제되었지만, tryptase의 mRNA 발현량은 저 농도에서만 억제되었다. 이상의 결과로 HemoHIM이 비만세포의 활성을 억제하는 효과가 있다는 것을 알 수 있었으며, 상대적으로 독성이 적은 항알레르기 제재로 개발할 가능성을 제시한 것으로 생각된다.

• BMB Reports
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• 제55권6호
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• pp.275-280
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• 2022

The treatment of atopic dermatitis (AD) is challenging due to its complex etiology. From epidermal disruption to chronic inflammation, various cells and inflammatory pathways contribute to the progression of AD. As with immunosuppressants, general inhibition of inflammatory pathways can be effective, but this approach is not suitable for long-term treatment due to its side effects. This study aimed to identify a plant extract (PE) with anti-inflammatory effects on multiple cell types involved in AD development and provide relevant mechanistic evidence. Degranulation was measured in RBL-2H3 cells to screen 30 PEs native to South Korea. To investigate the anti-inflammatory effects of Parasenecio auriculatus var. matsumurana Nakai extract (PAE) in AD, production of cytokines and nitric oxide, activation status of FcεRI and TLR4 signaling, cell-cell junction, and cell viability were evaluated using qRT-PCR, western blotting, confocal microscopy, Griess system, and an MTT assay in RBL-2H3, HEK293, RAW264.7, and HaCaT cells. For in vivo experiments, a DNCBinduced AD mouse model was constructed, and hematoxylin and eosin, periodic acid-Schiff, toluidine blue, and F4/80-staining were performed. The chemical constituents of PAE were analyzed by HPLC-MS. By measuring the anti-degranulation effects of 30 PEs in RBL-2H3 cells, we found that Paeonia lactiflora Pall., PA, and Rehmannia glutinosa (Gaertn.) Libosch. ex Steud. show an inhibitory activity of more than 50%. Of these, PAE most dramatically and consistently suppressed cytokine expression, including IL-4, IL-9, IL-13, and TNF-α. PAE potently inhibited FcεRI signaling, which mechanistically supports its basophil-stabilizing effects, and PAE downregulated cytokines and NO production in macrophages via perturbation of toll-like receptor signaling. Moreover, PAE suppressed cytokine production in keratinocytes and upregulated the expression of tight junction molecules ZO-1 and occludin. In a DNCB-induced AD mouse model, the topical application of PAE significantly improved atopic index scores, immune cell infiltration, cytokine expression, abnormal activation of signaling molecules in FcεRI and TLR signaling, and damaged skin structure compared with dexamethasone. The anti-inflammatory effect of PAE was mainly due to integerrimine. Our findings suggest that PAE could potently inhibit multi-inflammatory cells involved in AD development, synergistically block the propagation of inflammatory responses, and thus alleviate AD symptoms.

• Membrane and Water Treatment
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• 제1권2호
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• pp.139-158
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• 2010

This work focuses on the application of nanofiltration (NF) to the concentration of a pharmaceutical product, Clavulanate ($CA^-$), from clarified fermentation broths, which show a complex composition with six main identified ions ($K^+$, $Cl^-$, ${NH_4}^+$, $H_2{PO_4}^-$, ${SO_4}^{2-}$ and $CA^-$), glucose and glycerol. The solutes transport through the NF membrane pores was investigated using the SEDE (Steric, Electric and Dielectric Exclusion) model. This model was applied to predict the rejection rates of the initial feed solution and the final concentrated solution (10-fold concentrated solution). The best results were achieved with a single fitted parameter, ${\varepsilon}_p$ (the dielectric constant of the solution inside pores) and considering that the membrane selectivity is governed by steric, electric (Donnan) and Born dielectric exclusion mechanisms. While the predicted intrinsic rejections of solutions comprising up to six ions and uncharged solutes were in good agreement with the experimental values, the deviations were much larger for the 10-fold concentrated solution.

• 한국자동차공학회논문집
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• 제8권3호
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• pp.181-189
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• 2000

The aerodynamic characteristics of large transport vehicle has become more and more important in recent vehicle design to improve driving performance in high speed cruising and raise the product valve with regard to a comfortable driving condition. Hence, detailed knowledge of the flow field around truck coner vane is essential to improve fuel efficiency and reduce the dirt contamination on vehicle body surface. In this study, three-dimensional flow characteristics around corner vane attached to truck cabin were computed for the steady, incompressible, and high speed viscous flow, adopting the RNG k-$\varepsilon$ turbulence model. In order to investigate the influence of configuration and structure of corner vane, computations were carried out for four cases at a high Reynolds number, Re=4.1$\times$106 (based on the cabin height). The global flow patterns, drag coefficient and the distributions such as velocity magnitude, turbulent kinetic energy around the corner vane, were examined. As a result of this study, we could identify the flow characteristics around corner vane for the variation of corner vane length and width. Also, suggest the improved structure to reduce the dirt contamination in cabin side.

• Nuclear Engineering and Technology
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• 제50권6호
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• pp.944-949
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• 2018

The mass attenuation coefficients (${\mu}/{\rho}$) of food waste samples (pomegranate peel, acorn cap, lemon peel, mandarin peel, pumpkin peel, grape peel, orange peel, pineapple peel, acorn peel and grape stalk) have been measured employing a Si(Li) detector at 13.92, 17.75, 20.78, 26.34 and 59.54 keV. Also, the theoretical values of the mass attenuation coefficients have been evaluated utilizing mixture rule from WinXCOM program. The results showed that the lemon peel has the highest values of ${\mu}/{\rho}$ among the selected samples. From the obtained mass attenuation coefficients, we determined some absorption parameters such as effective atomic number ($Z_{eff}$), electron density ($N_E$) and molar extinction coefficient (${\varepsilon}$). It was found that the $Z_{eff}$ values of all food wastes lie within the range of 4.034-7.595, whereas the $N_E$ of the studied food wastes was found to be in the range of $0.301-1.720{\times}10^{25}$ (electrons/g) for present energy region.

• 한국수산과학회지
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• 제15권4호
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• pp.283-290
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• 1982

Sardine and mackerel so called dark muscled fish have been underutilized due to the disadvantages in bloody meat color, high content of fat, and postmortem instability of protein. Recent efforts were made to overcome these defects and develope new types of product such as texturized protein concentrates and dark muscle eliminated minced fish. Approach of this study is based on the rapid dehydration of foamed fish-starch paste by dielectric heating. In process comminuted sardine meat was washed more than three times by soaking and decanting in chilled water and finally centrifuged. The meat was ground in a stone mortar added Ivith adequate amounts of salt, foaming agent, and other ingredients for aid to elasticity and foam stability. The ground meat paste was extruded in finger shape and heated in a microwave oven to give foamed, expanded, and porous solid structure by dehydration. Dielectric onstant $(\varepsilon')$ and dielect.ic loss $(\varepsilon")$ values of sardine meat paste were influenced by wavelength and moisture level. Those values at 100 KHz and 15 MHz were ranged 2.25-9.86; 2.22-4,18 for E' and 0.24-19.24; 0.16-1.20 for E", respectively, at the moisture levels of $4.2-13.8\%$. For a formula for fish-starch paste preparation, addition of $20-30\%$ starch (potato starch) to the weight of fish meat, $2-4\%$ salt, and $5-10\%$ soybean protein was adequate to yield 4-5 folds of expansion in volume when heated. Addition of e99 yolk was of benefit to micronize foam size and better crispness. In order to provide better foaming and dehydration, addition of $0.2-0.5\%$sodium bicarbonate, foaming agent, was proper to result in foam size of 0.5-0.7 mm and foam density of $200-400\;/cm^2$ which gave a good crispness. Heating time was depended upon the moisture level of fish-starch paste. For a finger shaped paste (1.0cm. $D\times10cm.L$) heating for 150-200 sec. in a microwave oven (700W. 2.45GHz) was sufficient to generate foams, expand, and solidify the porous structure of fish-starch paste. When the moisture content was above $55\%$ browning and scorching was deepened due to over-expansion and over-heating whereas the crispness was hardened by insufficient expansion at lower moisture content. In quality evaluation of the product, chemical composition of $30\%$ starch and $3\%$ salt added product was moisture $8.8\%$, lipid $2.4\%$, carbohydrate $46.7\%$, protein $36.1\%$, and ash $6.0\%$. Eleven membered panel test evaluated that fish-starch paste was acceptable in color, crisp-ness, taste, except a trace of fishy odour which could be masked by the addition of spice extracts.

• 한국식품영양과학회지
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• 제24권5호
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• pp.816-828
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• 1995

식품의 가공처리나 저장 중에 단백질에 결합된 아미노산의 side chain이 상호간 또는 식품내 다른 분자들과 화학적으로 반응할 수 있다. 이 반응으로 아미노산의 구조적 파괴, recemization, 단백질의 상호작용들, 또한 환원성 당과, 산화제 및 polyphenol류와의 결합을 들 수 있다. 이들 중 Maillard 반응 (예 ; fructoselysinel과 아미노산 간의 cross-linking(예 ; lysinoalanine)에 의한 반응이 주를 이룬다. 이때 가장 영향을 받는 아미노산이 lysine으로, 이는 lysine이 기능성 유리 ${\varepsilon}-amino$ group을 갖고 있기 때문이다. 일반적으로 아미노산의 derivatives나 polypeptides내 cross-links는 단백질의 체내 이용율과 소화율을 감소시켜 단백질 식품의 품질을 떨어뜨린다. 본 논문에서는 식품낸의 lysinoalanine과 fructoselysine의 형성과 관련된 기술적, 분석적, 영양적 그리고 생리적인 문제들에 관하여 문헌고찰하였다. 결론적으로 식품내 이들의 존재가 여러가지 영향을 체내에서 미칠 수 있으나 정상 성인에게는 전혀 위험한 물질이 아님을 알 수 있었다. 그러나 제한된 formular foods를 주로 먹는 유아에게는 성장에 lysine이 필수적이므로 lysine 손상을 통한 단백질의 질 저하는 대단히 중요한 의미를 지닌다. 따라서 유아식의 가공처리와 저장에 주의를 해야할 필요가 있다고 본다.