• Archives of Pharmacal Research
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• v.27 no.7
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• pp.683-692
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• 2004

Curcumin (diferuloylmethane) is a major naturally-occurring polyphenol of Curcuma species, which is commonly used as a yellow coloring and flavoring agent in foods. Curcumin has shown anti-carcinogenic activity in animal models. Curcumin possesses anti-inflammatory activity and is a potent inhibitor of reactive oxygen-generating enzymes such as lipoxygenase/cyclooxygenase, xanthine dehydrogenase/oxidase and inducible nitric oxide synthase; and an effective inducer of heme oxygenase-1. Curcumin is also a potent inhibitor of protein kinase C(PKC), EGF(Epidermal growth factor)-receptor tyrosine kinase and LĸB kinase. Subsequently, curcumin inhibits the activation of NF(nucleor factor)KB and the expressions of oncogenes including c-jun, c-fos, c-myc, NIK, MAPKs, ERK, ELK, PI3K, Akt, CDKs and iNOS. It is proposed that curcumin may suppress tumor promotion through blocking signal transduction path-ways in the target cells. The oxidant tumor promoter TPA activates PKC by reacting with zinc thiolates present within the regulatory domain, while the oxidized form of cancer chemopreventive agent such as curcumin can inactivate PKC by oxidizing the vicinal thiols present within the catalytic domain. Recent studies indicated that proteasome-mediated degradation of cell proteins playa pivotal role in the regulation of several basic cellular processes including differentiation, proliferation, cell cycling, and apoptosis. It has been demonstrated that curcumin-induced apoptosis is mediated through the impairment of ubiquitin-proteasome pathway. Curcumin was first biotransformed to dihydrocurcumin and tetrahydrocurcumin and that these compounds subsequently were converted to monoglucuronide conjugates. These results suggest that curcumin-glucuronide, dihydrocurcumin-glucuronide, tetrahydrocurcumin-glucuronide and tetrahydrocurcumin are the major metabolites of curcumin in mice, rats and humans.

• Journal of Biomedical Engineering Research
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• v.44 no.2
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• pp.147-156
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• 2023

Efforts to employ smart home sensors to monitor the indoor activities of elderly single residents have been made to assess the feasibility of a safe and healthy lifestyle. However, the bathroom remains an area of blind spot. In this study, we have developed and evaluated a new edge computer device that can automatically detect water usage activities in the bathroom and record the activity log on a cloud server. Three kinds of sound as flushing, showering, and washing using wash basin generated during water usage were recorded and cut into 1-second scenes. These sound clips were then converted into a 2-dimensional image using MEL-spectrogram. Sound data augmentation techniques were adopted to obtain better learning effect from smaller number of data sets. These techniques, some of which are applied in time domain and others in frequency domain, increased the number of training data set by 30 times. A deep learning model, called CRNN, combining Convolutional Neural Network and Recurrent Neural Network was employed. The edge device was implemented using Raspberry Pi 4 and was equipped with a condenser microphone and amplifier to run the pre-trained model in real-time. The detected activities were recorded as text-based activity logs on a Firebase server. Performance was evaluated in two bathrooms for the three water usage activities, resulting in an accuracy of 96.1% and 88.2%, and F1 Score of 96.1% and 87.8%, respectively. Most of the classification errors were observed in the water sound from washing. In conclusion, this system demonstrates the potential for use in recording the activities as a lifelog of elderly single residents to a cloud server over the long-term.

• BMB Reports
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• v.43 no.2
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• pp.127-132
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• 2010

Phosphatidylinositol (3,4,5)-triphosphate ($PIP_3$) is a lipid second messenger that employs a wide range of downstream effector proteins for the regulation of cellular processes, including cell survival, polarization and proliferation. One of the most well characterized cytoplasmic targets of $PIP_3$, serine/threonine protein kinase B (PKB)/Akt, promotes cell survival by directly interacting with nucleophosmin (NPM)/B23, the nuclear target of $PIP_3$. Here, we report that nuclear $PIP_3$ competes with Akt to preferentially bind B23 in the nucleoplasm. Mutation of Arg23 and Arg25 in the PH domain of Akt prevents binding to $PIP_3$, but does not disrupt the Akt/B23 interaction. However, treatment with phosphatases PTEN or SHIP abrogates the association between Akt and B23, indicating that nuclear $PIP_3$ regulates the Akt/B23 interaction by controlling the concentration and subcellular dynamics of these two proteins.

• Journal of Internet Computing and Services
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• v.12 no.4
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• pp.107-117
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• 2011

The appearance of Web has brought an substantial revolution to all fields of society such knowledge management and business transaction as well as traditional information retrieval. In this paper, we propose an EFASIT(Extended Fuzzy AHP and SImilarity Technology) model considering the emotion analysis. And we combine the Extended Fuzzy AHP Method(EFAM) with SImilarity Technology(SIT) based on the domain corpus information in order to efficiently retrieve the document on the Web. The proposed the EFASIT model can generate the more definite rule according to integration of fuzzy knowledge of various decision-maker, and can give a help to decision-making, and confirms through the experiment.

• Journal of Life Science
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• v.11 no.1
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• pp.39-41
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• 2001

Cytohesin family has been thought to participate in inside-outside signaling linking growth factor receptor stimulation of PI 3-kinase to cell adhesion and stimulate nucleotide exchange of ARF through its Sec7 domain. The genomic structure of the cytohesin family was analyzed by BLAST search using cDNA and genomic DNA sequences from the GeneBank database. The cytohesin-2 was encoded by 12 exons. while the cytohesin-4 was encoded by 13 exons. The Sec7 and PH domains were not encoded by separate exons. In an analysis of retroviral integration, those two families did not contain any retroviral elements in introns or exons. The phylogenetic tree calculated by the neighbor-joining method suggests that the cytohesin-1 family was closely related to cytohesin-3 (ARNO3) family. These date could be of great use in further studies for resolving the exact function and evolution of the cytohesin family.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.29 no.9
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• pp.33-41
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• 2015

To improve the power quality of distributed generation (DG) systems even in the presence of distorted grid condition, dual current control scheme of a grid-connected inverter is proposed. The proposed current control scheme is achieved by decomposing the inverter state equations into the fundamental and harmonic components. The derived models are employed to design dual current controllers. The conventional PI decoupling current controller is used in the fundamental model to control the main power flow in DG systems. At the same time, the predictive control is applied in the harmonic model to suppress undesired harmonic currents to zero quickly. To decompose the voltage inputs and state variables into the fundamental and harmonic components, the fourth order band pass filter (BPF) is designed in the discrete-time domain for a digital implementation. For experimental verification, 2kVA prototype of a grid-connected inverter has been constructed using digital signal processor (DSP) TMS320F28335. The effectiveness of the proposed strategy is demonstrated through comparative simulation and experimental results.

• Korean Journal of Construction Engineering and Management
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• v.14 no.1
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• pp.144-152
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• 2013

Design is an iterative, generative, and multidisciplinary process by its nature. Iteration occurs often in most of the engineering design and development projects including construction. Design iterations cause rework, and extra efforts are required to get the optimal sequence and to manage the projects. Contrary to simple design, isolation of the generative iterations in complex design systems is very difficult, but reduction in overall iterations is possible. Design depends upon the information flow within domain and also among various design disciplines and organizations. Therefore, it is suggested that managers should be aware about the crucial iterations causing rework and optimal sequence as well. In this way, managers can handle design parameters related to such iterations pro-actively. There are a number of techniques to reduce iterations for various kinds of engineering designs. In this paper, parameter based Design Structure Matrix (DSM) is chosen. To create this DSM, a survey was performed and then partitioned using a model. This paper provides an easy approach to those companies involved in or intend to be involved in "design and build projects".

• Journal of IKEEE
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• v.24 no.3
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• pp.877-882
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• 2020

This paper presents performance comparison study of current control methods for grid connected inverter (GCI) system. Different current control methods have been developed for GCI systems and each controller has its own advantages and limitations. Steady state and transient dynamic performance of the GCI current controllers are compared in this paper. The performance of the proposed command feedforward control (CFFC) and disturbance rejection control (DRC) is analyzed before and after application to all GCI current controllers. The proposed CFFC and DRC control algorithms is analyzed in a frequency domain and the simulation and experiment models of each GCI current control methods are developed for verification of the performance.

• Journal of Magnetics
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• v.1 no.1
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• pp.46-50
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• 1996

Highly oriented ${BaFe_{12}{O_{19}$ films were obtained by a KrF excimer laser ablation technique using (110)$(012){Al_2}{O_3}$(001)$(012){Al_2}{O_3}$ and $(012){Al_2}{O_3}$ substrates, respectively.The degree of alignment of more than 95% were achieved for (100) on (110)$(012){Al_2}{O_3}$ and (001)$(001){Al_2}{O_3}$ planes, and heteroepitaxial films of (114) on (012)$(012){Al_2}{O_3}$were possible to be grown with a lasing energy density of 6.67 J/$cm^2$ at an oxygen partial pressure ${PO_2}$ of 900 mTorr. The best magnetic properties were obtained from the as-deposited films at the substrate temperature of $700^{\circ}C$, and post annealing treatment was not needed to enhance the magnetic properties. Experimentally saturated magnetization ($4_pi M_S$) of 3600~3800 Gauss and coercivities $(H_c)$ of 3050~3080 Oe, which approach 85% of those of Ba-ferrite bulk composed of single domain particles, were obtained in this study.

• The Transactions of the Korean Institute of Power Electronics
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• v.21 no.6
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• pp.457-464
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• 2016

This study proposes a bi-directional buck-boost converter controller design method for ESS using the MATLAB SISO tool. The conventional two-loop controller design is based on a continuous S-domain model that designs each controller independently. The demerit of the conventional method is that optimal performance is not easily achieved and extensive trials and errors are required because two-loop systems interact with one another. Using the MATLAB SISO tool based on the design method proposed in this work overcomes the disadvantages of the conventional method. In the proposed method, the SISO tool can select the location of the poles and zeroes of the open loop system, thereby facilitating the effective design of a high-performance controller. The design sequence is detailed systematically, and the performance of the method is verified with a computer simulation and 10 kW experimental system.