• 제어로봇시스템학회:학술대회논문집
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• 2003.10a
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• pp.428-432
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• 2003

Quantitative Feedback Theory (QFT) is one of most effective methods of robust controller design and can be considered as a suitable method for systems with parametric uncertainties. Particularly it allows us to obtain controllers less conservative than other methods like $H_{\infty}$ and ${\mu}$-synthesis. In QFT method, we transform all the uncertainties and desired specifications to some boundaries in Nichols chart and then we have to find the nominal loop transfer function such that satisfies the boundaries and has the minimum high frequency gain. The major drawback of the QFT method is that there is no effective and useful method for finding this nominal loop transfer function. The usual approach to this problem involves loop-shaping in the Nichols chart by manipulating the poles and zeros of the nominal loop transfer function. This process now aided by recently developed computer aided design tools proceeds by trial and error and its success often depends heavily on the experience of the loop-shaper. Thus for the novice and First time QFT user, there is a genuine need for an automatic loop-shaping tool to generate a first-cut solution. In this paper, we approach the automatic QFT loop-shaping problem by using an algorithm involving Linear Programming (LP) techniques and Genetic Algorithm (GA).

• 제어로봇시스템학회:학술대회논문집
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• 2003.10a
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• pp.433-437
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• 2003

Quantitative Feedback Theory (QFT) is one of effective methods of robust controller design. In QFT design we can considers the phase information of the perturbed plant so it is less conservative than $H_{\infty}$ and ${\mu}$-synthesis methods and as be shown, it is more transparent than the sensitivity reduction methods mentioned . In this paper we want to overcome the major drawback of QFT method which is lack of an automatic method for loop-shaping step of the method so we focus on the following problem: Given a nominal plant and QFT bounds, synthesize a controller that achieves closed-loop stability and satisfies the QFT boundaries. The usual approach to this problem involves loop-shaping in the frequency domain by manipulating the poles and zeros of the nominal loop transfer function. This process now aided by recently developed computer aided design tools proceeds by trial and error and its success often depends heavily on the experience of the loop-shaper. Thus for the novice and First time QFT user, there is a genuine need for an automatic loop-shaping tool to generate a first-cut solution. Clearly such an automatic process must involve some sort of optimization, and while recent results on convex optimization have found fruitful applications in other areas of control theory we have tried to use LMI theory for automating the loop-shaping step of QFT design.

• Journal of the Korean Institute of Intelligent Systems
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• v.14 no.4
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• pp.457-467
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• 2004

In this paper, a robot is considered as an agent, a structure of robot is presented which consisted by multi-subagents and they have diverse capacity such as perception, intelligence, action etc., required for robot. Also, subagents are consisted by micro-agent($\mu$agent) charged for elementary action required. The structure of robot control have two sub-agents, the one is behavior based reactive controller and action selection sub agent, and action selection sub-agent select a action based on the high label action and high performance, and which have a learning mechanism based on the reinforcement learning. For presented robot structure, it is easy to give intelligence to each element of action and a new approach of multi robot control. Presented robot is simulated for two goals: chaotic exploration and obstacle avoidance, and fabricated by using 8bit microcontroller, and experimented.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 1996.04a
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• pp.662-666
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• 1996

The variations of the surface topographical parameters for the analysis of the pedestrian slip and fall accidents during the sliding friction between the specially prepared floor specimens and three working shoes were investigated. The profile ordinate data for each flooring specimen were obtained at 1.1 .mu.m intervals using a laser scanning confocal microscope system along to the direction of sliding. A number of surface roughness parameters, that is, the centre line average (c.l.a.) and root mean square (r.m.s.) roughness, maximum height (Rtm), maximum mean peak height (Rpm), maximum mean depth (Rvm), and average asperity slope were calculated using a computer program and compared with the dynamic friction results. The analysis showed that the surface parameters undergo marked variations during the sliding process, but the variations were statistically significant. It was found that amongst various surface parameters, the maximum depth (Rvm) and the average asperity slope of the asperities were the biggest variation during the sliding proceeding. This result confirms the previous study and may suggests a new approach to monitoring the flooring environments with their service as the effort to reduce the pedestrain slip accident.

• JSTS:Journal of Semiconductor Technology and Science
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• v.16 no.6
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• pp.781-792
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• 2016

This paper presents a new approach to enhance the data retention of logic-compatible embedded DRAMs. The memory bit-cell in this work consists of two logic transistors implemented in generic triple-well CMOS process. The key idea is to use the parasitic junction capacitance built between the common cell-body and the data storage node. For each write access, a voltage transition on the cell-body couples up the data storage levels. This technique enhances the data retention and the read performance without using additional cell devices. The technique also provides much strong immunity from the write disturbance in the nature. Measurement results from a 64-kbit eDRAM test chip implemented in a 130 nm logic CMOS technology demonstrate the effectiveness of the proposed circuit technique. The refresh period for 99.9% bit yield measures $600{\mu}s$ at 1.1 V and $85^{\circ}C$, enhancing by % over the conventional design approach.

• Journal of Acupuncture Research
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• v.20 no.3
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• pp.34-44
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• 2003

Objective : Bone homeostasis is maintained by balance of bone formation and resorption. Therefore, bone related diseases arose by disturbance of this balance between osteoblast and osteoclast activities. To develop a successful screening system the therapeutic components based on oriental medicine is essential to set up systematic approach for that purpose. The purpose of this study is to the know the gene expression using cDNA microarray assay. Methods : Cervi Pantotricuhum Cornu Herbal-acupuncture extract was prepared by boiling. human osteosarcoma cells(HOS) were treated with Cervi Pantotricuhum Cornu Herbal-acupuncture solution. Then mRNA was extracted and cDNA microarray assay was performed. Results : Human osteosarcoma cells(HOS) treated with Cervi Pantotricuhum Cornu Herbal-acupuncture solution($500{\mu}g/m{\ell}$) showed that thioredoxin, TAFII31 and two novel genes were increased. However many genes decreased their expression by Cervi Pantotricuhum Cornu Herbal-acupuncture. Conclusions : This type of approach will give a good chance to explore the favorable effects of Cervi Pantotricuhum Cornu Herbal-acupuncture. Further study is needed for investigating the effect of Cervi Pantotricuhum Cornu Herbal-acupuncture.

• Journal of the Korean Institute of Telematics and Electronics C
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• v.34C no.2
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• pp.29-37
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• 1997

A new algorithm and parallel architecture for high-speed complex number multiplication is presented, and a prototype chip based on the proposed approach is designed. By employing redundant binary (RB) arithmetic, an N-bit complex number multiplication is simplified to two RB multiplications (i.e., an addition of N RB partial products), which are responsible for real and imaginary parts, respectively. Also, and efficient RB encoding scheme proposed in this paper enables to generate RB partial products without additional hardware and delay overheads compared with binary partial product generation. The proposed approach leads to a highly parallel architecture with regularity and modularity. As a results, it results in much simpler realization and higher performance than the classical method based on real multipliers and adders. As a test vehicle, a prototype 8-b complex number multiplier core has been fabricated using $0.8\mu\textrm{m}$ CMOS technology. It contains 11,500 transistors on the area of about $1.05 \times 1.34 textrm{mm}^2$. The functional and speed test results show that it can safely operate with 200 MHz clock at $V_{DD}=2.5 V$, and consumes about 90mW.

• Korean Journal of Remote Sensing
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• v.31 no.1
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• pp.39-46
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• 2015

Outgoing Longwave Radiation (OLR) is emitted energy from the Earth that is an important indicator of cooling effect in global scale and meteorological events in regional scale. Satellite-driven OLR products have its advantages overcoming spatially limited representation. The Korean geostationary satellite, Communication, Ocean and Meteorological Satellite (COMS), has been producing OLR product in accordance with its own algorithm since Apr. 2011. This study introduces Spatio-Temporally Equalized Match-up (STEM) approach to evaluate the COMS OLR products. We have tested a number of cases of thresholds set by standard deviations of a subpixel $10.8{\mu}m$ to find optimal representation of OLR in the selective match-up. Each case was then validated with broadband reference data, Clouds and the Earth's Radiant Energy System (CERES). We found that selective STEM approach was useful to validate OLR product especially its distribution in homogeneous grids.

• Journal of Chest Surgery
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• v.34 no.6
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• pp.447-453
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• 2001

Background: Although pulmonary resection is the standard approach for the management of pulmonary metastases from soft tissue sarcoma, most of them are unresectable and chemotherapy remains the only option. The effectiveness of the cytotoxic drugs may be limited by the toxicities that occur before the therapeutic dose is reached. The regional administration of doxorubicin using pulmonary arterial perfusion in a rodent model can produce 10 to 25 times higher concentrations in the lung than systemic administration with minimal systemic toxicities. However, it is unclear whether a high concentration of doxorubicin has beneficial effects for killing cancer cells. Material and Method: We studied this to evaluate the dose-dependent cytotoxic and apoptotic effects of doxorubicin on methylcholanthrene-induced rat fibrosarcoma(MCA) cells. This study examined the cytotoxicity and apoptosis-related gene expressions(Fas, FasL, Bax, caspase 1, caspase 2, caspase 8, Bcl-2, Bcl-xL, Bcl-xS) in MCA cells after 24 hours exposure to various concentrations of doxorubicin such as 1, 5, 10, 50, and 100 $\mu$M. Result: Dose-dependent cytotoxicity was observed after 24 hours exposure to doxorubicin. However, peak apoptosis after 24 hours exposure was observed at 5 $\mu$M of doxorubicin. Above 5 $\mu$M, apoptotic activity was decreased with dose-increment. All mRNA levels of apoptosis-related genes after 24 hours exposure were up-regulated above the control level at 1 $\mu$M of doxorubicin and then decreased by doxorubicin dose-increment except caspase 8, which showed higher levels than the control level at 5 $\mu$M. Apoptosis-related protein levels were highest at 1 $\mu$M of doxorubicin and then decreased by doxorubicin dose-increment. However, Bax and Bcl-xL proteins steadily showed higher levels than the control throughout the different concentrations of doxorubicin. Conclusion: These results suggest that apoptosis is the main cytotoxic mechanism in low concentrations of doxorubicin in MCA cells and apoptosis-related genes, such as Bax, caspase 8, and Bcl-xL, are involved. At high concentrations, doxorubicin still can kill MCA cells, even when apoptosis is inhibited, and have its propriety for achieving much cytotoxicity against MCA cells.

• Journal of Ginseng Research
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• v.37 no.3
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• pp.283-292
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• 2013

Ginsenosides are divided into two groups based on the types of the panaxadiol group (e.g., ginsenoside-Rb1 and -Rc) and the panaxatriol group (e.g., ginsenoside-Rg1 and -Re). Among them, ginsenoside-Re (G-Re) is one of the compounds with the highest content in Panax ginseng and is responsible for pharmacological effects. However, it is not yet well reported if G-Re increases the hemodynamics functions on ischemia (30 min)/reperfusion (120 min) (I/R) induction. Therefore, in the present study, we investigated whether treatment of G-Re facilitated the recovery of hemodynamic parameters (heart rate, perfusion pressure, aortic flow, coronary flow, and cardiac output) and left ventricular developed pressure (${\pm}dp/dt_{max}$). This research is designed to study the effects of G-Re by studying electrocardiographic changes such as QRS interval, QT interval and R-R interval, and inflammatory marker such as tissue necrosis factor-${\alpha}$ (TNF-${\alpha}$) in heart tissue in I/R-induced heart. From the results, I/R induction gave a significant increase in QRS interval, QT interval and R-R interval, but showed decrease in all hemodynamic parameters. I/R induction resulted in increased TNF-${\alpha}$ level. Treatment of G-Re at 30 and $100{\mu}M$ doses before I/R induction significantly prevented the decrease in hemodynamic parameters, ameliorated the electrocardiographic abnormality, and inhibited TNF-${\alpha}$ level. In this study, G-Re at $100{\mu}M$ dose exerted more beneficial effects on cardiac function and preservation of myocardium in I/R injury than $30{\mu}M$. Collectively, these results indicate that G-Re has distinct cardioprotectective effects in I/R induced rat heart.