• Journal of Acupuncture Research
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• v.18 no.6
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• pp.240-249
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• 2001

Obejective : Based on ${\ll}$sixty-ninth Nan${\gg}$ (${\ll}$難經${\cdot}$六十九難${\gg}$) the interpromoting of the five element's balance method to discuss following 'when deficiency than should strengthen mother and when excessive than eliminate son' theories. Method : This strengthening and eliminating method is based on Jang-bu organ's balance method when 'east is excessive (liver excessive (肝實 )) and west is deficiency (lung deficiency (肺虛))' then 'eliminate the south and strengthen the north's method. Results : The seventy-fifth Nan (${\ll}$難經${\cdot}$七十五難${\gg}$) explains' son effects mother's excessive and mother effects son's deficiency' theory where it balance method of the inter-overacting five elements controlling Jang-bu organ's differentiations. The eighty-first Nan (${\ll}$難經${\cdot}$八十一難${\gg}$) explains strengthening-eliminating method of 'lung excessive and liver deficiency.' Since there are two different perspective of seventy-fifth and eighty-first Nan, we must compare and discuss to make right point of view. Conclusion : the treatment method in ${\ll}$Nan kyoung sixty ninth nan${\gg}$ could be understood as a view of five element constitutional theory (五行體質理論), the treatment method in ${\ll}$Nan kyoung seventyty-fifth nan${\gg}$ of eleminating fire and strengthning water in case of liver excess and lung defficiency and the treatment method in ${\ll}$Nan kyoung eighty-first nan${\gg}$ of strengthning liver and eleminating lung in case of lung excess and liver defficiency could be understood as a view of the yin-yan constitutional theory (陰陽體質理論).

• Journal of Acupuncture Research
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• v.18 no.6
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• pp.250-263
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• 2001

Objective : I refered to oriental medical records to study on the use Ohaeng-acupuncture through compared ${\ll}$Classic on Difficulty${\gg}$ with . Methods : The original text about ${\ll}$Classic on Difficulty${\gg}$ was used ${\ll}$Nan Jing Ben YI${\gg}$, annotations were excerpted and record that were necessary for this study. The structural formula was composed together to compare ${\ll}$Classic on Difficulty${\gg}$ with . Results : ${\ll}$Classic on Difficulty${\gg}$ deals with fundamental medical theories and gives differentiation of syndromes of some diseases in the form of questions and answers. ${\ll}$The Sixty nineth Difficulty, Classic on Difficulty${\gg}$ 'Xu Ze Bu Qi Mu(虛者補其母), Shi Ze Xie Qi Zi (實者瀉其子)' that united ${\ll}$Ling Shu(靈樞) - Jing Mai(經脈篇)${\gg}$ 'Sheng Ze Xie Zhi(盛則瀉之) Xu Ze Bu Zhi(虛則補之)' with Ohaeng-xiangsheng theory is the base of the 'Bu Xie (補瀉)'. ${\ll}$The seventy fifth Difficulty, Classic on Difficulty${\gg}$ 'Xie Nan Huo (瀉南方火) Bu Bei Shui (補北方火)' that based Ohaeng-xiangke theory and the 'Qu Xue(取穴)' takes the form of the 'Bu Mu Xie Zi (補母瀉子)' in standard of internal organs which are etiologic al cause named 'Shi(實)'.

• Journal of Acupuncture Research
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• v.19 no.5
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• pp.1-9
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• 2002

Objective : The study of relations between twelve meridians and pulse diagnosis Method : The possiblity of pulse diagnosis on the pulse points(脈動處) of each meridian through the scription of $\ll$Maek beop(脈法)$\gg$ $\ll$Nae kyeong(內經)$\gg$ and $\ll$Nan kyeong(難經$\gg$ Result : The comparative pulse diagnosis method(比較脈診法) in the scription of $\ll$Mack beop$\gg$ progressed to the five Jang bu maek(五臟脈) in the scription of $\ll$Young chu : Sa gi jang bu byeong hyeong(靈樞 邪氣臟腑病形)$\gg$ in accordance with the progress of pulse diagnosis and the theory of medicine. Conclusions : The comparative pulse diagnosis method in the scription of $\ll$Mack beop)$\gg$ progressed to the five Jang bu maek(五臟脈) in the scription of $\ll$Young chu : Sa gi jang bu byeong hyeong$\gg$ and the moxibustion and Pyum bup(貶法) in the scription of $\ll$Mack beop$\gg$ altered to acupuncture therapy on the five shu points(五輸穴)

• Bulletin of the Korean Chemical Society
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• v.33 no.9
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• pp.2883-2889
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• 2012

LL-37 is the only antimicrobial peptide (AMP) of the human cathelicidin family. In addition to potent antimicrobial activity, LL-37 is known to have the potential to inhibit lipolysaccharide (LPS)-induced endotoxic effects. To provide the stability to proteolytic digestion and increase prokaryotic selectivity and/or anti-endotoxic activity of two Lys/Trp-substituted 19-meric antimicrobial peptides (a4-W1 and a4-W2) designed from IG-19 (residues 13-31 of LL-37), we synthesized the diastereomeric peptides (a4-W1-D and a4-W2-D) with D-amino acid substitution at positions 3, 7, 10, 13 and 17 of a4-W1 and a4-W2, respectively and the enantiomeric peptides (a4-W1-E and a4-W2-E) composed D-amino acids. The diastereomeric peptides exhibited the best prokaryotic selectivity and effective protease stability, but no or less anti-endotoxic activity. In contrast, the enantiomeric peptides had not only prokaryotic selectivity and anti-endotoxic activity but also protease stability. Our results suggest that the hydrophobicity and ${\alpha}$-helicity of the peptide is important for anti-endotoxic activity. In particular, the enantiomeric peptides showed potent anti-endotoxic and LPS-neutralizing activities comparable to that of LL-37. Taken together, both a4-W1-E and a4-W2-E holds promise as a template for the development of peptide antibiotics for the treatment of endotoxic shock and sepsis.

• Journal of Acupuncture Research
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• v.19 no.4
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• pp.124-131
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• 2002

Objective : The purpose of this study is to research for the formation of Ohaeng-acupuncture. Methods : I refered to ${\ll}$Classic on Difficulty${\gg}$ (難經), ${\ll}$Ling Shu${\gg}$ (靈樞), ${\ll}$Zhen Jiu Ju Ying${\gg}$ (針灸聚英), ${\ll}$Yi Xue Ru Men${\gg}$ (醫學入門) and annotations were excerpted and record that notied the Ohaeng-acupuncture. Results : The results obtained as follows. 1. ${\ll}$Ling Shu${\gg}$ "Sheng Ze Xie Zhi, Xu Ze Bu Zhi"(盛則瀉之, 虛則補之) united with "Ying Sui Bu Xie"(迎隨補瀉), developed the principle of "Qu Xue" in ${\ll}$Classic on Difficulty${\gg}$. 2. ${\ll}$Classic on Difficulty${\gg}$ explained the interdependent relations, interrestraining relations, the relations of subjugation and reverse restriction in illness condition between the five viscera according to the theory of generation, restriction, subjugation and reverse restriction in five elements. ${\ll}$Classic on Difficulty${\gg}$ united five shu points (五兪穴) with five elements. 3. Zi jing Bu xie according to Xiang Sheng theory is develped from ${\ll}$Classic on Difficulty${\gg}$ "Xu Ze Bu Qu Mu, Shi Ze Xie Qi Zi"(虛則補其母 實則瀉其子) to ${\ll}$Classic on Difficulty${\gg}$ , ${\ll}$Zhen Jiu Ju Ying${\gg}$. 4. Ta jing Bu xie according to Xiang Sheng theory is develped from ${\ll}$Tu Zhu Nan Jing${\gg}$ to ${\ll}$Yi Xue Ru Men${\gg}$. 5. The principle of treatment according to Zi-Ta jing Bu xie based Xiang Ke is develped from ${\ll}$The seventy fifth Difficulty Classic on Difficulty${\gg}$ to Sa Am Do In(舍岩道人).

• Journal of Acupuncture Research
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• v.21 no.1
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• pp.1-20
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• 2004

Pulse-feeling took its origin from making a diagnosis along meridians in the course of discovering and forming meridians and for a long time its meaning was mixed with meridians in the course of recognizing "The Pulse" then was separated from meridians in the early days of Western Han Dynasty. Ancient pulse-feeling methods are pulse-feeling method by the twelve regular meridians, pulse-feeling method by three regions and nine modes, pulse-feeling method by Inyeong(人迎) and Chon-gu(寸口), etc. Pulse-feeling was changed in proportion to diagnostic purpose and method of treating and if method and region of pulse-feeling is arranged, we will infer correlation between meridians and pulse-feeling and will infer transitional system of past pulse-feeling and will forecast transition of future pulse-feeling. As the result that I study the transition of the above three pulse-feeling methods of meridians diagnosis: 1. Three pulse-feeling methods of meridians diagnosis flowed into diagnostic method by taking pulse of setting six region for Chon(寸), Gwan(關) and Cheok(尺), i.e. the Chon[寸] spot pulse of $\ll$Nan-gyeong$\gg$ and were changed into diagnostic method being fit for use of five Su points, The Front-Mo points and Back-Su points that grasp the pathology of mutual internal organs and treat the disease. 2. Today it is suggesting the transition of another pulse-feeling method that do not apply diagnostic method by taking pulse of setting six region for Chon(寸), Gwan(關) and Cheok(尺), i.e. the Chon[寸] spot pulse of $\ll$Nan-gyeong$\gg$ to 19C Sasang(四象) Constitutional Medicine or 20C Eight Constitutional Medicine.

• Journal of Acupuncture Research
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• v.20 no.6
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• pp.103-119
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• 2003

Below are the reports arranged from the research of ${\ll}$XiFangZiMingTangJiuJing(西方子明堂灸經)${\gg}$, which appears in the research of the main issue. ${\ll}$XiFangZiMingTangJiuJing${\gg}$ was written during the Nan-song period, approximately between 1142~1194, and was probably completed between 1142~1148. This book is the very first book specific on the moxibustion theory which exists these days and also thoroughly contains the moxibustion theory. So it contains many documents of the moxibustion theory which are missing these days. Also it's possible that the illustration presented in this book followed ${\ll}$MingTangJing(明堂經)${\gg}$ of SunSiMiao(孫思邈). The way of arranging the GuiJing(歸經) of YuZue(兪穴) and deciding the location of acupuncturing(穴位) differs from reports given by other documents. As seen above, ${\ll}$XiFangZiMingTangJiuJing${\gg}$ has a consulting value on the moxibustion theroy(灸法), both in clinic and the research of documents. So we are looking forward that there would be a more profound research continuing in the future.

• Journal of Acupuncture Research
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• v.20 no.1
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• pp.1-12
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• 2003

Objectives : The purpose of this study is to compare Xingjian(LR2) Shaofu(HT8) with Dadun(LR1) Shaofu(HT8) on Blood Pressure in Hypertensive RAT induced by Two Kidney One Clip(2KIC). Methods : This experiments was to investigate the effects of LR2 HT8(originated from ${\ll}$Classic on Difficulty${\gg}$ Shi Ze Xie Qi Zi), LR1 HT8(originated from ${\ll}$Ling Shu${\gg}$ Sheng Ze Xie Zhi) acupuncture on the blood pressure, cardiomegalic index, and plasma levels of atrial natriuretic peptide in hypertensive rat induced by 2K1C. Results: 1. Blood pressure was decreased significantly after third acupuncture of LR2 HT8. 2. Blood pressure was decreased significantly after acupuncture of LR2 HT8, but was increased after LR2 HT8. 3. Cardiomegalic index was not changed after acupuncture of LR2-HT8 and LR1-HT8 4. Plasma levels of atrial natriuretic peptide was increased significantly after acupuncture of LR2 HT8 but LR1 HT8 was not changed.

• Journal of Korean Medical classics
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• v.13 no.1
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• pp.44-73
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• 2000

I examined throughout where Sa Gi Gang Boo Byung Hyung(邪氣藏府病形) was shown. It is shown in many books, such as Young Chu(靈樞), Kab Eul Kyung(甲乙經), Nan Kyung(難經), Yu Kyung(類經), etc. Sa Gi Gang Boo Byung Hyung got its name by how its contents pointed to the mechanism of getting harmed by Sa Gi(邪氣), and the forms of diseases which were led from five organs and six hollow viscera getting harmed by Sa Gi(邪氣). Sa Gi Gang Boo Byung Hyung is divided into three chapters which are divided altogether into nine sections. The first chapter is on the mechanism of Sa Gi(邪氣)' s harming the five organs and the six hollow viscera. Going into details, it discusses that Sa Gi has got two different ways which are divided into Yum Yang(陰陽) to harm the organs and the hollow viscera. Next, it discusses how faces can endure the cold that well. The second chapter is on the essences such as symptoms, face colors, shapes of pulse, and conditions on the interior part of the elbow. In the first section, it discusses how figures, colors and pulses relate together. In the second section, it discusses different diseases have different pulses and conditions on the interior part of the elbow. The third section is on forms of diseases in five organs and six hollow viscera. The third chapter is on acupuncture. The first section is about acupuncturing six channels. The second is about acupuncture points which is compared to the sea by its function. The third is about the forms of diseases with discussing symptoms and acupuncture points. The forth is about the essence of acupuncture. The ten different pulses of each five organs, and the masses of five organs in Nan Kyung(難經), and Jang Bu Mak Jin Beob(臟腑脈診法) in Eu Hak Yib Moon(醫學入門) are based on 'The six different pulses of each five organs' which is shown in the third section, second chapter. Besides, it plays an important role in study and it can play an important role as well in doctoring such as inspecting, taking pulses and so on. Thus, I found Sa Gi Gang Boo Byung Hyung worth while to study. But, Sa Gi Gang Boo Gyung Hyung was written in ancient letters and was omitted in many parts, which led successive doctors to write different explanatory notes. Thus, I researched the exact meaning through successive explanatory notes.

• Journal of National Security and Military Science
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• s.7
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• pp.155-231
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• 2009

Xu-Jing(徐競) an official of the Song(宋), a medieval Kingdom of China, wrote a book titled $\ll$Koryo Tu Jing(高麗圖經)$\gg$ which explains his travel to the Koryo as a member of diplomatic mission in 1123. $\ll$Koryo Tu Jing$\gg$ is the record of his personal experience in Koryo with many explanatory illustrations and especially contains 5 months' voyage record of his diplomatic fleet. His fleet set sail at a port located in the Ding Hai Xian(定海縣), Ming Zhou(明州) via a few islands of Koryo [Hyup Kye San(俠界山) , the Kun San Do(群山島) , the Ja Yon Do(紫燕島) , the Keup Su Mun(急水門) in Kang Hwa Gun(江華郡) and the Hap Gul(蛤窟) ] and finally arrived the Port Ye Song Hang(禮成港) . According to the Xu-Jing's record his fleet sailed the sea with the help of the favorable seaward winds and tides as the usual way of ancient sailing. The Xu- Jing's Fleet sailed the sea between the Mei Cen(梅岑), Ming Zhou(明州) of China and the Hyup Kye San(俠界山) of Koryo from about 5:00 a.m., May 24th(of the lunar calendar) to about 5:00 p.m., June 2nd. At this section, the average speed of the seaward winds was 19.45km/h and the average speed of the fleet which sailed only by the power of the winds was 6.29km/h. This means that 32.3% of the favorable seaward winds' speed was equal to the speed of the ancient fleet which sailed only by the power of the favorable seaward winds. The fleet sailed the sea between the Ja Yon Do(紫燕島) and the Keup Su Mun(急水門) from about 9:00 a.m., June 10th to about 1:00 p.m., the same day. At this section the fleet sailed by the power of tides in addition to the favorable seaward winds without oaring. The average speed of the winds was not different from that of former section and the average speed of the tides was 1.937km/h. And at this section the average speed of the fleet increased by 0.41km/h than that of the former section. This means that 21.1% of the speed of the tides was equal to the increased speed of the ancient fleet by virtue of the tides. The fleet sailed the sea between Keup Su Mun(急水門) and the Hap Gul(蛤窟) from about 1:00 p.m., June 10th to about 3:00 p.m., the same day. At this section, there were no seaward winds and the fleet sailed only by the powers of tides and oaring. And at this section, the tide increased the average speed of the fleet by 0.3114km/h and the fleet could sail at the speed of 4.3km/h. So we can conclude that the average speed of ancient fleet without any influences of the seaward winds and tides was 3.98 km/h. We can make use of the various sailing speeds of ancient fleets when judging their maritime activities. If we make use of the various sailing speeds of the ancient fleets as calculated in this article, we will be able to get various important informations about the certain ancient fleet's maritime maneuver. For example, we can infer the sailing routs of a certain fleet and the time when the fleet passed a certain spot by making use of the various sailing speeds of the ancient fleet. In this article I did not take account of the shapes of ships that consist of the ancient fleets and the sizes of the various ships and fleets. It was because that such factors would not change the foresaid conclusions seriously.