• Korean Journal of Health Education and Promotion
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• 제2권1호
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• pp.31-61
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• 2000

Introduction. Despite the fact that half of premature deaths are caused by unhealthy lifestyles such as smoking tobacco, sedentary lifestyle, alcohol and drug abuse and poor nutrition, there are no theoretical models which accurately explain these health promotion related behaviors. This study tests a new model of health behavior called the Model of Health Promotion Behavior. This model draws on elements and frameworks suggested by the Health Belief Model, Social Cognitive Theory, the Theory of Planned Action and the Health Promotion Model. This model is intended as a general model of behavior but this first test of the model uses amount of exercise as the outcome behavior. Design. This study utilized a cross sectional mail-out, mail-back survey design to determine the elements within the model that best explained intentions to exercise and those that best explained amount of exercise. A follow-up questionnaire was mailed to all respondents to the first questionnaire about 10 months after the initial survey. A pretest was conducted to refine the questionnaire and a pilot study to test the protocols and assumptions used to calculate the required sample size. Sample. The sample was drawn from 2000 eligible participants at two blue collar (utility company and part of a hospital) and two white collar (bank and pharmaceutical) companies located in Southeastern Michigan. Both white collar site had employee fitness centers and all four sites offered health promotion programs. In the first survey, 982 responses were received (49.1％) after two mailings to non-respondents and one additional mailing to secure answers to missing data, with 845 usable cases for the analyzing current intentions and 918 usable cases for the explaining of amount of current exercise analysis. In the follow-up survey, questionnaires were mailed to the 982 employees who responded to the initial survey. After one follow-up mailing to non-respondents, and one mailing to secure answers to missing data, 697 (71.0％) responses were received, with 627 (63.8％) usable cases to predict intentions and 673 (68.5％) usable cases to predict amount of exercise. Measures. The questionnaire in the initial survey had 15 scales and 134 items; these scales measured each of the variables in the model. Thirteen of the scales were drawn from the literature, all had Cronbach's alpha scores above .74 and all but three had scores above .80. The questionnaire in the second mailing had only 10 items, and measured only outcome variables. Analysis. The analysis included calculation of scale scores, Cronbach's alpha, zero order correlations, and factor analysis, ordinary least square analysis, hierarchical tests of interaction terms and path analysis, and comparisons of results based on a random split of the data and splits based on gender and employer site. The power of the regression analysis was .99 at the .01 significance level for the model as a whole. Results. Self efficacy and Non-Health Benefits emerged as the most powerful predictors of Intentions to exercise, together explaining approximately 19％ of the variance in future Intentions. Intentions, and the interaction of Intentions with Barriers, with Support of Friends, and with Self Efficacy were the most consistent predictors of amount of future exercise, together explaining 38％ of the variance. With the inclusion of Prior Exercise History the model explained 52％ of the variance in amount of exercise 10 months later. There were very few differences in the variables that emerged as important predictors of intentions or exercise in the different employer sites or between males and females. Discussion. This new model is viable in predicting intentions to exercise and amount of exercise, both in absolute terms and when compared to existing models.

• 한국심리학회지ㆍ건강
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• 제14권3호
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• pp.579-596
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• 2009

본 연구는 한국형 치료동의 능력평가도구를 개발하여 이 도구의 신뢰도와 타당도를 검증하고 각 하위능력별 능력, 무능력을 구별할 수 있는 최적의 절단점을 알아보기 위해서 이루어졌다. 본 연구 참여자는 정신의료기관에 입원해 있는 정신질환자, 지역사회정신보건센터 및 사회복귀시설 프로그램에 참여하고 있는 정신질환자 중 본 연구의 참여에 동의한 사람으로, 정신분열증 160명, 기분장애 32명, 기타(강박장애, 알코올) 1명으로 총 193명이었다. 이해능력(understanding), 적용능력(appreciation), 표현능력(expression of a choice), 추론능력(reasoning) 등 총 14문항으로 구성되어 있는 본 치료 동의능력 평가도구와 타당도를 알아보기 위해서 K-MMSE, 지능, 통찰력검사, BPRS를 실시하였다. 그 결과 이 도구의 평정자간의 일치도가 .80~.98로 매우 높고 내적 일관성계수 역시 .56~.83으로 신뢰할만한 수준이었다. 본 도구의 구성개념 타당화를 확인적 요인분석으로 알아본 결과 타당한 것으로 나타났고, 준거관련 타당화를 위해 MMSE, BPRS, IQ, 병식을 검사한 결과 IQ, MMSE는 동의능력 중 이해, 적용, 선택의 표현, 추론 능력 모두와 의미 있는 상관관계를 가지는 것으로 나타났다. ROC 분석 결과 본 척도의 절단점으로 전체점수 18.5점, 하위 영역들의 절단점은 이해능력 4.5, 적용능력 8.5, 의사 표현 0.5, 추론 3.5점이 제안되었다. 이런 결과는 본 연구자들이 개발한 척도가 신뢰롭고 타당하며 진단성 효용성을 지님을 나타낸다. 마지막으로 본 연구의 시사점과 제한점에 대하여 논의하였다.

• 구강회복응용과학지
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• 제39권3호
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• pp.105-118
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• 2023

목적: 본 연구는 치과 보철물 거래 플랫폼 서비스의 중요성을 이해하고, 보다 넓은 적용을 위해 필수 요소를 파악하는 것을 목표로 하였다. 연구 재료 및 방법: 치과 의사, 치과 기공사, 치과 위생사, 그리고 치과 산업 종사자들을 대상으로 치과 보철물 주문 및 관련 플랫폼 서비스에 대한 견해를 평가하기 위해 설문 조사를 실시하였다(총 53명). 이를 위해 설문지는 치과 전문가의 검토를 거쳐 작성되었고, Cronbach's alpha coefficient를 사용하여 설문지의 신뢰도를 평가하였다. 요인 분석을 통해 총 변동의 88.417%를 설명하는 5개 범주의 57개 요인을 도출했다. 설문 조사는 온라인 설문지 플랫폼을 통해 실시되었으며, 데이터 분석은 통계 소프트웨어를 사용하여 one-way analysis of variance과 Tukey's honestly significant difference test을 사용하여 수행되었다(α = 0.05). 결과: 주문 시에 정확한 정보 입력, 효과적인 의사소통, 변형 없는 치과 인상체 전달, 데이터 전송 및 저장의 편리성, 안정적이고 합리적인 가격의 플랫폼 서비스 제공이 필수 요소로 확인되었다(P < 0.05). 또한, 이러한 항목의 중요성에는 연령, 치과 직업, 경력 경험에 따른 유의한 차이가 관찰되었다(P < 0.05). 결론: 치과 보철물 주문 플랫폼 서비스에 대한 치과 종사자들의 요구사항은 안정성과 경제성, 그리고 치과 보철물 데이터 전송 및 저장의 용이성이었다. 이러한 결과는 앞으로 치과 보철물 주문 및 관련 플랫폼 서비스의 개발 및 개선을 위한 중요한 지표가 될 수 있다.

• 대한한의학방제학회지
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• 제15권1호
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• pp.163-173
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• 2007

Jeungaektang (JAT) is the herbal formula, has the effect of moistening the dryness by activating lung Qi and by nourishing Yin, has being used for dryness syndromes. Generally the herbal formulae for moistening dryness are used for exogenous or endogenous dryness syndromes. JAT has been clinically used for the treatment of endogenous dryness syndromes. It is composed of Scrophulariae Radix. Rehmanniae Radix and Liriopis Tuber. Recent studies showed that JAT has a protective effect against $CCl_{4}-induced$ hepatotoxicity and anti-inflammatory effects against ear swelling of mouse induced by Crotonis Fructus. However, the effect of JAT on the immunological activity was rarely studied. Therefore, this study evaluated the effects of JAT the regulatory mechanism of nitric oxide (NO) and cytokines in the lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. After the treatment of JAT water extract, cell viability was measured by MTT assay, NO production was monitored by measuring the nitrite content in culture medium. Cyclooxygenase-2 (COX -2) and inducible nitric oxide synthase (iNOS) were determined by immunoblot analysis, and levels of cytokine were analyzed by sandwich immunoassays. Results provided evidence that JAT inhibited the production of nitrite and nitrate ($0.1{\sim}1.0$ mg/ml), iNOS ($0.1{\sim}1.0$ mg/ml), $interleukin-1{\beta}$ ( $0.1{\sim}1.0$ mg/ml) and tumor necrosis $factor-{\alpha}$ ($0.1{\sim}1.0$ mg/ml) in RAW 264.7 cells activated with LPS. Furthermore, JAT inhibited the expression of COX-2 expression and production of prostagladin E2 ($0.1{\sim}1.0$ mg/ml). These findings suggest that JAT can produce anti-inflammatory effect, which may play a role in adjunctive therapy in Gram-negative bacterial infections.

• 한국가정과교육학회지
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• 제24권4호
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• pp.59-75
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• 2012

본 연구는 중국 청소년들의 다이어트에 대한 인식도 및 지식수준을 파악하고 이들이 체형 및 다이어트에 대한 올바른 인식을 갖도록 하는데 필요한 기초자료를 제공하기 위하여 중국 치박시(淄博市)에 재학 중인 남녀 고등학생 260명을 대상으로 2012년 2월에 설문지를 통한 자기기입식 방법을 통해 실시되었다. 본 연구에서 수집된 자료는 SPSS Windows V.19.0 프로그램을 이용하여 빈도분석, 요인분석, 신뢰도 분석, t 분석, 일원분산분석, Duncan의 사후검증분석, $Χ^2$ 검증을 실시하였다. 연구결과, 자신의 체형에 대해 응답자의 40.8%가 보통, 38.5%가 뚱뚱한 편, 그리고 20.8%가 마른 편으로 인식하고 있었다. 성별에 따른 BMI와 체형에 대한 인식도를 살펴보면 남학생에 비해 여학생의 경우 자신의 체형을 비만으로 잘못 인식하는 경향이 많은 것으로 나타났다. 다이어트에 대한 관심도를 살펴보면 조사대상자의 과반수가 다이어트에 관심이 없는 것으로 나타나서 다이어트에 대해 관심도가 대체로 낮은 것으로 나타났다. 다이어트에 대한 인식도의 통계치를 살펴보면 '마른 몸매 추구'의 평균값이 가장 높았고 그 다음으로는 '다이어트 정보 및 교육 요구', '다이어트 필요성' 순으로 나타났다. 한편 다이어트에 대한 지식의 평균 정답률은 54.0%로 높지 않았으며, 성별, 자아 체형에 대한 인식도, 현재 BMI에 따라 통계적으로 유의한 차이는 없는 것으로 나타났다. 조사대상자들은 다이어트에 대한 정보를 인터넷의 블로그, 미니홈피, 지식검색에서 가장 많이 얻는 것으로 나타났으며, 그 다음으로는 전파매체, 가족이나 친구들 순이었다. 또한 다이어트 실행 여부를 조사한 결과, 응답자 중 22.6%만이 다이어트를 실행해 본적이 있거나 다이어트를 실행하고 있는 것으로 나타났다. 다이어트 실행자를 대상으로 다이어트를 하게 된 동기를 질의한 결과 가장 많은 응답을 보인 것은 '스스로 표준체형이 아니라고 생각하여'이었고, 다이어트 실천자들의 각 요법에 대한 실천 정도를 살펴본 결과 절식요법, 운동요법, 식품요법, 한증요법, 약물/기구요법, 전문기관 이용요법 순으로 많이 하는 것으로 나타났다.

• 대한치과보철학회지
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• 제51권2호
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• pp.82-89
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• 2013

연구 목적: 본 연구는 양극산화 임플란트에 골형성단백질과 혈관내피세포성장인자를 코팅한 임플란트를 토끼의 경골에 식립하여 골과 임플란트 계면의 골유착 향상의 가능성을 평가하고자 시행하였다. 연구 재료 및 방법: 6마리의 토끼 양측 경골에 코팅을 하지 않은 양극 산화 임플란트(대조군)와 골형성단백질과 혈관내피세포성장인자를 코팅한 임플란트(실험군)을 각각 한쪽에 2개씩 식립하였다, 토끼는 2주, 8주에 각각 3마리씩 희생하였고 전체 식립된 임플란트는 24개이었다. 각 시기별, 그룹별 임플란트 수는 각각 6개씩이었다. 임플란트안정지수(resonance frequency analysis (RFA)), 회전 제거력(Removable torque measurement (RTQ))을 희생 시기에 측정하였다. 독립표본 t-test (SPSS Ver. 15.0, Chicago, USA)을 이용하여 2주, 8주에서 대조군과 실험군의 차이를 비교 분석하고, 유의수준95%에서 통계적으로 검정하였다. 결과:대조군과 실험군 모두 8주에서 우수한 골유착을 보였다. 특히 실험군에서 8주에 ISQ, RTQ 값 모두 대조군과 비교하여 우수한 값을 나타내었다 (P<.05). 하지만 2주에서는 두군 사이에 통계적 유의성을 보이지 않았다(P>.05). 결론: 골형성 단백질과 혈관내피세포성장인자를 임플란트 표면에 코팅하여 식립하는 것은 치유의 후반기에 골유착을 증대하는 것으로 사료된다.

• International Journal of Oral Biology
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• 제37권3호
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• pp.137-145
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• 2012

Aggregatibacter actinomycetemcomitans is the most important etiologic agent of aggressive periodontitis and can interact with endothelial cells. Monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) are chemokines, playing important roles in periodontal pathogenesis. In our current study, the effects of A. actinomycetemcomitans on the production of MCP-1 and IL-8 by human umbilical vein endothelial cells (HUVEC) were investigated. A. actinomycetemcomitans strongly induced the gene expression and protein release of both MCP-1 and IL-8 in a dose- and time-dependent manner. Dead A. actinomycetemcomitans cells were as effective as live bacteria in this induction. Treatment of HUVEC with cytochalasin D, an inhibitor of endocytosis, did not affect the mRNA up-regulation of MCP-1 and IL-8 by A. actinomycetemcomitans. However, genistein, an inhibitor of protein tyrosine kinases, substantially inhibited the MCP-1 and IL-8 production by A. actinomycetemcomitans, whereas pharmacological inhibition of each of three members of mitogen-activated protein (MAP) kinase family had little effect. Furthermore, gel shift assays showed that A. actinomycetemcomitans induces a biphasic activation (early at 1-2 h and late at 8-16 h) of nuclear factor-${\kappa}B$ (NF-${\kappa}B$) and an early brief activation (0.5-2 h) of activator protein-1 (AP-1). Activation of canonical NF-${\kappa}B$ pathway ($I{\kappa}B$ kinase activation and $I{\kappa}B-{\alpha}$ degradation) was also demonstrated in these experiments. Although lipopolysaccharide from A. actinomycetemcomitans also induced NF-${\kappa}B$ activation, this activation profile over time differed from that of live A. actinomycetemcomitans. These results suggest that the expression of MCP-1 and IL-8 is potently increased by A. actinomycetemcomitans in endothelial cells, and that the viability of A. actinomycetemcomitans and bacterial internalization are not required for this effect, whereas the activation of protein tyrosine kinase(s), NF-${\kappa}B$, and AP-1 appears to play important roles. The secretion of high levels of MCP-1 and IL-8 resulting from interactions of A. actinomycetemcomitans with endothelial cells may thus contribute to the pathogenesis of aggressive periodontitis.

• Asian-Australasian Journal of Animal Sciences
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• 제31권5호
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• pp.705-711
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• 2018

Objective: This experiment was conducted to evaluate the effects of golden needle mushroom (Flammulina velutipes) stem waste (FVW), on organic eggs production, calcium utilization, antibody response, serum immunoglobulin, and serum cytokine concentration at early phase of production in laying hens. Methods: A total 210, 19 weeks old aged ISA Brown layers were randomly assigned into 5 equal treatment groups, with 7 replications of 6 hens each. Dietary treatment included a standard basal diet as control; antibiotic (0.05% flavomycin); 2% FVW; 4% FVW; and 6% FVW. The experimental duration was 10 weeks. Results: There was no significant differences (p>0.05) on hen day egg production, egg weight, egg mass, feed intake, and feed conversion ratio (FCR) among experimental groups. Unmarketable eggs were significantly lower (p<0.05) both in 4% FVW and 6% FVW fed groups than control group. The calcium retention and calcium in egg shell deposition were significantly higher (p<0.05) in FVW inclusion groups than control and antibiotic groups. Antibody titers against Newcastle diseases were significantly higher (p<0.05) in 6% FVW fed group (except combined with 4% FVW at day 147) and infectious bronchitis were significantly higher (p<0.05) in FVW fed groups (except 2% FVW and 4% FVW at day 161) than control and antibiotic groups. Serum immunoglobulin sIgA was significantly higher (p<0.05) in all levels of FVW and IgG was significantly higher (p<0.05) in 4% FVW than control and antibiotic groups. Serum cytokine concentration interleukin-2 (IL-2) was significantly higher (p<0.05) in 6% FVW; IL-6 and tumor necrotic $factor-{\alpha}$ were significantly higher (p<0.05) both in 4% FVW and 6% FVW than control and antibiotic groups; IL-4 was significantly higher (p<0.05) in antibiotic, 2% FVW and 4% FVW fed groups than control. Conclusion: F. velutipes mushroom waste can be used as a novel substitute for antibiotic for organic egg production and sound health status in laying hens.

• 간호행정학회지
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• 제8권1호
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• pp.107-121
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• 2002

The purpose of this study was to identify how nurse's image was perceived by nursing college students. The subjects included were 315 students experienced clinical practice during $20{\sim}22$ weeks and 134 students not with a total of 449 nursing students in Gwangju and Chonnam. The data were collected from November 21 to December 5, 2001 by the structured questionnaires. The research tool was measured by 30 items divided into four dimensions; traditional, professional, social and personal image of nurse. Cronbach $\alpha$ for the tool of nurse's image was 0.8960. The data were analysed by SPSS 8.0 for Windows program using frequency, percentage, mean, standard deviation, t-test, ANOVA and scheffe. The results of this study were as follows; 1. In the nurse's image related to general characteristics, there were significant differences for school graduation, applicative motivation, interpersonal relationship and image forming factor. 2. In the Image forming factors, nursing college students perceived the nurse's image by visiting hospital or admission(37.9%), watching TV(25.8) and others; nurses' appearance during clinical experience(16.3). 3. The mean score for nurse's image of clinical experience group (2.76$\pm$0.28) was lower than that of non-clinical experience group(2.89$\pm$0.31) in significance (t=4.319, p=0.000). 4. In the nurse's image according to clinical experience, there were significant differences for traditional, professional, social, personal image between two groups and the lower mean scores were found in the clinical experience group in all dimensions. The ranks of dimensions were professional image(3.08), traditional image(2.76), social image(2.65), the personal image(2.59) in clinical experience group, whereas professional image(3.21), traditional image(2.93), social image(2.75), personal image(2.71) for non-clinical experience group.5. The high score items of nurse's image were 'worthwhile work(3.48)', 'always working hard(3.30)', 'profession(3.17)', 'strong responsibility toward work(3.08)', 'have a high technical skill(3.05)' in clinical experience group and 'worthwhile work(3.69)', 'always working hard(3.28)', 'clean and decent(3.22)', 'profession(3.21)', 'have a bountiful professional knowledge(3.18)' in non-clinical experience group. 6. The highest mean score for nurse's image related to the image forming factors was 86.8 by novels or literature and the second highest was 84.3 by visiting hospital or admission. And others(mean=82.1)was the most negative nurse's image by clinical experience. In conclusion, nurse's image perceived by nursing college students will be the mirror of themselves. And clinical experience will be the important opportunity to form the professional image with white uniformed nurses in future. Therefore it is important for clinical nurses to play professional roles rightly so that nursing students could form positive nurse's image.

• Asian Pacific Journal of Cancer Prevention
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• 제14권6호
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• pp.3877-3880
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• 2013

Objective: To explore the expression and significance of tumor specific growth factor (TSGF), carcinoembryonic antigen (CEA) and alpha fetoprotein (AFP) in cancer tissue and serum of patients with colon cancer. Materials and Methods: Radical surgery for colon cancer was performed on 43 patients with laparoscopu under conditions of general anesthesia. The Elisa method was used to detect the levels of serum TSGF, CEA and AFP before and after radical operation, and cancer tissue underwent TSGF, CEA and AFP immunohistochemistry staining after laparoscopic surgery. The decreased conditions of serum TSGF, CEA and AFP in patients with colon cancer at different levels of differentiation and clinical stagings were analyzed, and the relationships of expression rates between histological types, colon cancer morphology, lymph node metastasis and TSGF, CEA as well as AFP in cancer tissue were assessed. Results: Compared with before radical surgery, the levels of serum TSGF, CEA and AFP decreased notably in patients after operations (p<0.01). The decreased degree of TSGF and CEA was the largest in patients with poorly differentiated cancer tissue (p<0.01), while that of AFP was noted in patients with moderately differentiated cancer tissue (p<0.01). The decreased degree of TSGF and AFP was the largest in patients at phase Dukes A (p<0.01), while that of CEA in patients at phase Dukes C (p<0.01). There were no significant differences among the positive expression rates of TSGF, CEA and AFP with different histological types and colon cancer morphologies (p>0.05). The positive expression rates of TSGF and CEA in patients with lymph node metastasis were significantly higher than those without lymph node metastasis (p<0.01). Conclusions: TSGF, CEA and AFP can be used to evaluate the effect of radical operation for colon cancer, and the changed levels of different markers are associated with tumor differentiation, clinical stating and presence or absence of lymph node metastasis.