• Bulletin of the Korean Chemical Society
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• 제26권8호
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• pp.1246-1250
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• 2005

We have evaluated the hydroxyl group-solvent specific interactions by using a Lichrosorb RP18 stationary phase and by measuring the retention data of carefully selected solutes in 50/50, 60/40, 70/30, 80/20, and 90/10(v/v%) methanol/water eluents at 25, 30, 35, 40, 45, and 50 ${^{\circ}C}$. The selected solutes are 3 positional isomers of phenylpropanol, that is, 1-phenyl-1-propanol, 1-phenyl-2-propanol, and 3-phenyl-1-propanol. There exist clear discrepancies in ${\Delta}H^o$ (solute transfer enthalpy from the mobile to the stationary phase) and $T{\Delta}S^o$ (solute transfer entropy) among positional isomers. The difference in ${\Delta}H^o$ and $T{\Delta}S^o$ between secondary alcohols (1-phenyl-1-propanol and 1-phenyl-2-propanol)is negligible compared to the difference between the primary alcohol (1-phenyl-3-propanol) and secondary alcohols. The $T{\Delta}S^o$ values of 3-phenyl-1-propanol are close to those of butylbenzene while the $T{\Delta}S^o$ values of secondary alcohols are close to those of propylbenzene. The difference in ${\Delta}{\Delta}H^o$ (specific solute-mobile phase interaction enthalpy) between the primary alcohol and the secondary alcohol decreases with increase of methanol content in the mobile phase. A unique observation is an extremum for 1-phenyl-3-propanol in the plot of $T{\Delta}{\Delta}S^o$ vs. methanol volume %. The positive sign of $T{\Delta}{\Delta}S^o$ of 3-phenyl-1-propanol implies that the entropy of 3-phenyl-1-propanol is greater than that of the hypothetical alkylbenzene (the same size and shape as phenylpropanol) in the mobile phase.

• Tuberculosis and Respiratory Diseases
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• 제44권1호
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• pp.44-51
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• 1997

연구배경 : 최근 알려진 ${\gamma}{\delta}$ 수용체는 결핵균 감염의 초기에 제2형 주요 조직적합성 복합계(MHC class II)의 인식없이 결핵균 항원에 반응하여 세포성 면역반응을 나타냄이 보고되었다. 이에 연구자등은 페결핵환자와 결핵성 흉막염 환자, 그리고 다른 원인의 흉막염 환자사이에 T 림프구의 조성과 ${\gamma}{\delta}$ T-림프구 수의 차이를 관찰하였다. 방법 : 대상은 폐결핵환자 30예(이중 결핵성 흉막염환자 15예), 폐암 환자 12예(이중 악성 흉막염 환자 9예), 폐렴 7예(이중 폐렴성 흉막염 6예)등 모두 49예였다. 혈청 ADA(adenosine deaminase)활성도는 Hitachi 747 자동화학분석기에서 측정하였다. T 세포 림프구 아형의 분류는 lysed whole blood method로 anti-Leu4, anti-Leu3a, anti-Leu2a, anti HLA-DR 그리고 anti-TCR-${\gamma}{\delta}$-1를 이용하여 flow cytometer로 분석하였다. 결과 : 1. 말초혈액내 ${\gamma}{\delta}$-T 림프구의 평균치는 $4.8{\pm}4.6%$ 였고, 결핵군(29예) $5.5{\pm}4.5%$, 비결핵군(14예) $3.3{\pm}2.9%$(폐암군 $4.0{\pm}3.2%$, 폐렴군 $2.2{\pm}1.6%$로 유의한 차이는 없었다(p=0.24). 질병의 이환기간 1개월 이내의 환자중에서도 결핵군(20예) $6.4{\pm}6.6%$, 비결핵군(14예) $3.3{\pm}2.9%$ 으로 유의한 차이는 없었다(p=0.16)(Table 1). 2. 흉막액내 T 세포 림프구 아형중 CD4 림프구는 결핵성 흉막액에서는 $54.6{\pm}13.8%$, 비결핵성 흉막액에서는 $36.2{\pm}25.3%$(악성 흉막액 $38.4{\pm}23.8%$, 폐렴정 흉막액 $30.1{\pm}34.0%$ 결핵성 흉막액에서 의의있게 높았다(p=0.04)(Table 2). 3. 흉막염이 있던 환자에서 말초혈액내 ${\gamma}{\delta}$-T 림프구는 결핵성 흉막염군(14예)이 $7.0{\pm}9.0%$, 비결핵성 흉막염군(11예) $3.0{\pm}2.0%$ (악성 흉막염군 $3.1{\pm}2.2%$, 폐렴성 흉막염군 $2.7{\pm}1.7%$로 차이는 없었다(p=0.16). 흉막액내 ${\gamma}{\delta}$-T 림프구는 결핵성 흉막염군(15예)이 $3.9{\pm}2.9%$, 비결핵성 흉막염군(10예) $2.1{\pm}2.2%$(악성 흉막염군 $2.0{\pm}2.5%$, 폐렴성 흉막염군 $2.4{\pm}1.7%$ 로 유의한 차이가 없었다(p=0.12). 4. 환자의 연령이나 성별과 말초혈액내 ${\gamma}{\delta}$-T 림프구수와는 상관관계가 없었고, 폐결핵 환자에서 병변의 정도, 혈청 및 흉막액내 ADA와 ${\gamma}{\delta}$-T 림프구수와도 상관관계가 없었다. 결론 : 결핵성 흉막염환자에서 말초혈액 및 흉막액내 ${\gamma}{\delta}$-T 림프구수의 유의한 증가는 없어 다른 질환과의 감별진단에 도움이 되지 못할 것으로 생각되며, ${\gamma}{\delta}$-T 림프구의 증가는 결핵 초기 환자들을 대상으로 추가 연구가 필요할 것으로 생각된다.

• Journal of applied mathematics & informatics
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• 제36권3_4호
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• pp.213-229
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• 2018

In this work, we establish oscillation of the second order sublinear neutral delay dynamic equations of the form:$$(r(t)((x(t)+p(t)x({\tau}(t)))^{\Delta})^{\gamma})^{\Delta}+q(t)x^{\gamma}({\alpha}(t))+v(t)x^{\gamma}({\eta}(t))=0$$ on a time scale T by means of Riccati transformation technique, under the assumptions $${\displaystyle\smashmargin{2}{\int\nolimits^{\infty}}_{t_0}}\({\frac{1}{r(t)}}\)^{\frac{1}{\gamma}}{\Delta}t={\infty}$$, and ${\displaystyle\smashmargin{2}{\int\nolimits^{\infty}}_{t_0}}\({\frac{1}{r(t)}}\)^{\frac{1}{\gamma}}{\Delta}t$ < ${\infty}$, for various ranges of p(t), where 0 < ${\gamma}{\leq}1$ is a quotient of odd positive integers.

• 마이크로전자및패키징학회지
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• 제25권4호
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• pp.67-74
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• 2018

두께가 $20{\mu}m$이며, 직경이 각기 $100{\mu}m$, $300{\mu}m$, $500{\mu}m$인 p형 $Sb_2Te_3$와 n형 $Bi_2Te_3$ 박막레그들을 전기도금하여 열전박막모듈을 형성한 후, 박막레그의 직경에 따른 출력전압과 출력전력을 비교하였다. $100{\mu}m$ 직경 박막레그들로 구성된 모듈은 ${\Delta}T=36.7K$에서 365 mV, $300{\mu}m$ 직경 박막레그들로 형성한 모듈은 ${\Delta}T=37.5K$에서 142 mV, $500{\mu}m$ 직경 박막레그들로 제작한 모듈은 ${\Delta}T=36.1K$에서 53 mV의 open circuit 전압을 나타내었다. $100{\mu}m$ 직경 박막레그 모듈은 ${\Delta}T=36.7K$에서 $845{\mu}W$, $300{\mu}m$ 직경 박막레그 모듈은 ${\Delta}T=37.5K$에서 $631{\mu}W$, $500{\mu}m$ 직경 박막레그 모듈은 ${\Delta}T=36.1K$에서 $276{\mu}W$의 최대출력전력을 나타내었다.

• 한국경영과학회:학술대회논문집
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• 한국경영과학회 1996년도 추계학술대회발표논문집; 고려대학교, 서울; 26 Oct. 1996
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• pp.295-298
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• 1996

We consider a nonpreemptive single-machine scheduling problem to minimize the mean squared deviation(MSD) of job completion times about a common due date d with a maximum tardiness constraint, i.e., maximum tardiness is less than or equal to the given allowable amount, .DELTA.(MSD/T$_{max}$ problem). We classify the .DELTA.-unconstrained cases in the MSD/T$_{max}$ problem. We provide bounds to discern each case for the problem. It is also shown that the .DELTA.-unconstrained MSD/T$_{max}$ problem is equivalent to the unconstrained MSD problem and the tightly .DELTA.-constrained MSD/T$_{max}$ problem with n jobs and a maximum allowable tardiness .DELTA. can be converted into the constrained MSD problem with a common due date .DELTA. and n-1 jobs. Finally, the solution procedure for MSD/T$_{max}$ problem is provided. provided.

• 대한수학회보
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• 제43권4호
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• pp.693-701
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• 2006

Using Minimax principle and Linking theorem in critical point theory, we prove the existence of two nontrivial solutions for the following second order superlinear difference systems $$(P)\{{\Delta}^2x(k-1)+g(k,y(k))=0,\;k{\in}[1,\;T],\;{\Delta}^2y(k-1)+f(k,\;x(k)=0,\;k{\in}[1,\;T],\;x(0)=y(0)=0,\;x(T+1)=y(T+1)=0$$ where T is a positive integer, [1, T] is the discrete interval {1, 2,..., T}, ${\Delat}x(k)=x(k+1)-x(k)$ is the forward difference operator and ${\Delta}^2x(k)={\Delta}({\Delta}x(k))$.

• IMMUNE NETWORK
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• 제5권1호
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• pp.23-29
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• 2005

Background: Interleukin-7 receptor (IL-7R) ${\alpha}$-deficient mice have small numbers of B cells and ${\alpha}{\beta}$T cells in periphery, they totally lack ${\gamma}{\delta}$T cells. In addition, the V-J recombination and transcription of TCR ${\gamma}$ genes is also severely impaired in IL-7R ${\alpha}$-deficient mice. Stat5, a signaling molecule of the IL-7R, induces germline transcription in the TCR ${\gamma}$ locus, and promotes V-J recombination and ${\gamma}{\delta}$T cell development. However, the roles for IL-7R signaling pathway in thymic or extrathymic ${\gamma}{\delta}$T cell development are largely unknown. Methods: To clarify the role of the IL-7 receptor in proliferation and survival of ${\gamma}{\delta}$T cells, we introduced the TCR ${\gamma}{\delta}$ transgene, $V_{{\gamma}2}/V{\delta}_5$, into IL-7R ${\alpha}$-deficient mice, and investigated the development of ${\gamma}{\delta}$T cells. Results: We found that $V_{{\gamma}2}/V{\delta}_5$ transgene restored ${\gamma}{\delta}$T cells in the epithelium of the small intestine (IEL) but not in the thymus and the spleen. Further addition of a bcl-2 transgene resulted in partial recovery of ${\gamma}{\delta}$T cells in the thymus and the spleen of these mice. Conclusion: Taken together, this study revealed that the IL-7R ${\alpha}$ is indispensable for proliferation and survival mainly in thymic ${\gamma}{\delta}$T cell development.

• 대한화학회지
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• 제39권5호
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• pp.384-392
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• 1995

$BiCl_3$의 승화압과 엔탈피를 370.6에서 488.8 K까지 Knudsen 유출법을 사용하여 측정하였고, 또한 438.2에서 495.7 K까지 Torsion 유출법에 의해 추가 실험을 하였다. 평형 승화압도 이 안정상태 데이터로부터 구하였다. ${\Delta}_{sub}H^0_{298.15}$와 ${\Delta}_{sub}S^0_{298.15}$의 상관관계를 이용하여, 추천할 수 있는 p(T) 식을 $BiCl_3(s)$에 의해 아래와 같이 구하였다. $BiCl_3(s); \; log(p/Pa)=－C/(T/K)\;－2.838log(T/K)－8.097{\times}10^{-2}(K/T)^2＋22.588$, 여기서 p는 파스칼, T는 절대온도, ${\Delta}_{sub}H^0_{298.15}$의 단위는 kJ $mol^{-1}$이고, $C=({\Delta}_{sub}H^0_{298.15}＋5.9988)/1.9146{\times}10^{-2}$이다. 응축상수와 그것의 온도 의존성도 위의 두 방법에 의한 실험으로부터 유도하였다.

• Journal of applied mathematics & informatics
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• 제30권5_6호
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• pp.1005-1021
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• 2012

This work is concerned with oscillation of the second order sublinear neutral delay dynamic equations of the form $$\(r(t)\;\((y(t)+p(t)y(a(t)))^{\Delta}\)^{\gamma}\)^{\Delta}+q(t)y^{\gamma}({\beta}(t))=0$$ on a time scale $\mathcal{T}$ by means of Riccati transformation technique, under the assumptions $\int^{\infty}_{t_0}\(\frac{1}{r(t)}\)^{\frac{1}{\gamma}}$ ${\Delta}t={\infty}$ and $\int^{\infty}_{t_0}\(\frac{1}{r(t)}\)^{\frac{1}{\gamma}}$ ${\Delta}t$ < ${\infty}$, where 0 < ${\gamma}{\leq}1$ is a quotient of odd positive integers.

• Asian Pacific Journal of Cancer Prevention
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• 제15권2호
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• pp.775-780
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• 2014

Objectives: TCR-gamma-delta+T cells (${\gamma}{\delta}$ T cells) are non-conventional T lymphocytes that can recognize and eradicate tumor cells. Our previous studies showed that infiltration and function of ${\gamma}{\delta}$ T cells were substantially attenuated in hepatocellular carcinoma (HCC). However, their prognostic value was not clarified. Methods: The association between ${\gamma}{\delta}$ T cells and the clinical outcomes was determined by immunohistochemistry (IHC) in a HCC patient cohort (n = 342). Results:Immunohistochemistry showed decreased infiltration of ${\gamma}{\delta}$ T cells in tumoral tissues compared with paired peritumoral tissues. The counts of ${\gamma}{\delta}$ T cells in peritumoral tissues were negatively correlated with tumor size (P = 0.005). Survival analysis showed that the levels of peritumoral ${\gamma}{\delta}$T cells were related to both time to recurrence (TTR) and overall survival (OS) (P = 0.010 and P = 0.036, respectively) in univariate analysis, and related to TTR in multivariate analysis (P = 0.014, H.R. [95% CI] = 0.682 [0.502-0.927]). Furthermore, the level of peritumoral ${\gamma}{\delta}$ T cells showed independent prognostic value for TTR in Barcelona Clinic Liver Cancer (BCLC) stage A patients (P = 0.038, H.R. [95% CI] = 0.727 [0.537-0.984]). However, tumoral ${\gamma}{\delta}$ T cells did not show independent prognostic value for either TTR or OS in HCC patients. Conclusions: Low counts of ${\gamma}{\delta}$ T cells in peritumoral liver tissue are related to a higher incidence of recurrence in HCC and can predict postoperative recurrence, especially in those with early-stage HCC.