• 한국주조공학회지
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• 제33권1호
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• pp.13-21
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• 2013

The effects of rare earth element (R.E.) and cooling rate on the eutectic reaction of flake graphite cast irons were studied by combined analysis of macro/micro-structure and cooling curve data. The correlation between eutectic reaction parameter and macro/micro-structure was systematically investigated. Two sets of chemical compositions with the different addition of R.E. were designed to cast. Three types of molds for cylindrical specimens with the different diameters were prepared to analyze cooling rate effect. The difference between undercooling temperature and cementite eutectic temperature (${\Delta}T_1=T_{U}-T_{E,C}$), which is increased by adding R.E. and decreased by increasing cooling rate, is considered to be a suitable eutectic reaction parameter for predicting graphite morphology. According to the criterion, A-type graphite is mainly suggested to form for ${\Delta}T_1$ over $20^{\circ}C$. Eutectic reaction time (${\Delta}t$), which is decreased by adding R.E. or increasing cooling rate, is a suitable eutectic reaction parameter for predicting eutectic cell size. Eutectic cell size is found to decrease in a proportion to the decrease of ${\Delta}t$.

• Animal cells and systems
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• 제13권4호
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• pp.391-397
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• 2009

The house dust mite (Dermatophagoides pteronissinus) is an important factor in triggering allergic diseases. The function of eosinophils, particularly in the production of cytokine or chemokine, is critical in understanding the pathogenesis of inflammatory diseases. In this study, we examined whether D. pteronissinus extract (DpE) induces the expression of monocyte chemotactic protein 1 (MCP-1)/CCL2, IL-8/CXCL8, and IL-6 that mediate in the infiltration and activation of immune cells and in its signaling mechanism in the human eosinophilic cell line, EoL-1. DpE increased the mRNA and protein expression of MCP-1, IL-8, and IL-6 in a time- and dose-dependent course in EoL-1 cells. In our experiments using signal-specific inhibitors, we found that the increased expression of MCP-1, IL-8, and IL-6 due to DpE is associated with Src family tyrosine kinase and protein kinase C $\delta$ (PKC $\delta$). In addition, the activation of extracellular signal-regulated kinase (ERK) is required for MCP-1 and IL-8 expression while p38 mitogen-activated protein kinase (MAPK) is involved in IL-6 expression. DpE induced the phosphorylation of ERK and p38 MAPK. PP2, an inhibitor of Src family tyrosine kinase, and rottlerin, an inhibitor of PKC $\delta$, blocked the activation of ERK and p38 MAPK. DpE induces the activation of ERK and p38 MAPK via Src family tyrosine kinase and PKC $\delta$ for MCP-1, IL-8, or IL-6 production. Increased cytokine release due to the house dust mite and the characterization of its signal transduction may be valuable in understanding the eosinophil-related pathogenic mechanism of inflammatory diseases.

• Restorative Dentistry and Endodontics
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• 제40권4호
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• pp.270-275
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• 2015

Objectives: This study examined the color changes of a resin composite with different shades upon exposure to water with different pH. Materials and Methods: Nanohybrid resin composites (Filtek Z350XT, 3M ESPE) with four different shades (A2, A3, B1, and B2) were immersed in water with three different pH (pH 3, 6, and 9) for 14 day. The CIE $L^*a^*b^*$ color coordinates of the specimens were evaluated before and after immersion in the solutions. The color difference (${\Delta}E^*$) and the translucency parameter (TP) were calculated using the color coordinates. Results: ${\Delta}E^*$ ranged from 0.33 to 1.58, and the values were affected significantly by the pH. The specimens immersed in a pH 6 solution showed the highest ${\Delta}E^*$ values (0.87 - 1.58). The specimens with a B1 shade showed the lowest ${\Delta}E^*$ change compared to the other shades. TP ranged from 7.01 to 9.46 depending on the pH and resin shade. The TP difference between before and after immersion in the pH solutions was less than 1.0. Conclusions: The resulting change of color of the tested specimens did not appear to be clinically problematic because the color difference was < 1.6 in the acidic, neutral, and alkaline solutions regardless of the resin shade, i.e., the color change was imperceptible.

• 구강회복응용과학지
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• 제23권2호
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• pp.157-170
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• 2007

Purpose: This investigation was designed to determine the translucency and color stability of various core ceramics for all-ceramic restoration using the CIE $L^*a^*b^*$ system. Material and Methods: IPS e.max Press ceramic(Ivoclar-Vivadent, Liechtenstein), $LAVA^{TM}$ All Ceramic(3M-Espe, Germany), Cercon Smart Ceramic(Dentsply, Germany), and Z-match Ceramic(DentAim, Korea) were used for this study. For the specimens of zirconia oxide ceramics, the as-sintered cylindrical blanks($11.0{\times}25.0mm$) were machined into the shape of a disk(0.4, 0.8, 1.5 mm in thickness, 10 mm in diameters) with a diamond grind machine. The IPS e.max Press specimens ($0.8{\times}10mm$) were fabricated using the "lost wax" technique. CIE $L^*a^*b^*$ coordinates and light transmission were recorded for each specimen with a spectrophotometer(CM-2600d, Minolta, Japan). Color differences were calculated using the equation, ${\Delta}E^*ab=[({\Delta}L^*)2+({\Delta}a^*)2+({\Delta}b^*)2]1/2$. Results: The results were obtained as follows: 1. The most translucent group was IPS e.max Press ceramic that is a glass-ceramic, and $Lava^{TM}$ and Z-match ceramic were more translucent than Cercon Smart ceramic in zirconia ceramic group. 2. In the all groups, there was no significant translucent change after 6 times heat-treatments required to make a final restoration. 3. Colored zirconia was showed more yellowish and dark than uncolored zirconia. 4. After heat-pressing, IPS e.max Press ceramic was showed high ${\Delta}E^*ab$ value(4.1 of eM1, 6.8 of eM2) that means to be more whiter than before heat-pressing. However, there was no color change after additive heat treatments for final restoration. 5. In the colored zirconia groups, there was no significant color change after some heat-treatments required to make a final restoration.

• 한국자기학회지
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• 제11권5호
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• pp.232-238
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• 2001

Nano결정립 N $d_2$F $e_{14}$B+F $e_3$B 복합상 자성 압분체의 탈자화 현상을 자기특성 변화 및 $\delta$M측정에 의해 분석하였다. 초기 조성 N $d_4$F $e_{73.5}$ $Co_3$H $f_{0.5}$G $a_{0.5}$ $B_{18.5}$의 최대자기에너지적은 리본상태에서 14 MGOe, 분말 압분체에서 6.5 MGOe로 크게 감소하였다. 이러한 현상은 복합상의 리본상태에서 존재하는 교환상호작용력이 분말 압분체에서는 나타나지 않고, 정자장 작용에 의한 탈자화로 인해 잔류자속밀도가 크게 감소한 결과이다. 이는 급냉리본(bulk) 보다 압분체상태에서 정자장 상호작용력이 교환상호작용력보다 더 크게 작용하는 결과로 해석된다. 또한, 자성체 리본을 분쇄하는 과정에서 발생한 응력도 자기특성을 감소시키는 요소임을 확인하였다.하였다.하였다.

• KSBB Journal
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• 제11권1호
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• pp.8-14
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• 1996

Bacillus subtilis를 재조합이종 단백질 생산에 응 용하고 그 발현효율의 향상을 위하여, aprE 프로모 터를 모델계로서 이에 작용하는 전이상태 조절유전 자 변이와 포자형성변이의 영향을 살펴보았다. 사용 된 균주는 두 개의 프로테아제가 제거된 DB104이며, 조절인자 변이주는 $degU^h$와 hpr을 각각 활성인자와 억제인자로 선택하였고, 이중변이주는 DB104 ($\DeltaspoIIG(Pm) degU^h his^+$) 및 DB104($\DeltaspoIIG(Pm) \Deltahpr(Em)$) 를 제조하였다. 이에 목적유전 자연 aprE유전자를 재조합하여 변이에 의한 과발현 양상을 확인하였다. degUh 및 hpr 조절변이주는 야 생주와 비교하여 각각 약 7배 빛 약 2배의 발현효율 향상을 보여주었다. 이들 전이상태 조절유전자 변이 는 모두 목적유전자 복제 수의 증가에 따라 발현효 율의 감소를 나타내어 증폭된 목적유전자에 대한 조 절유전자의 희석효과(gene dosage effect)를 확인할 수 있었다. 이중변이주 DB104($\DeltaspoIIG(Pm) degU^h his^+$)::pMK101 및 DB104($\DeltaspoIIG(Pm) \Deltahpr(Em)$)::pMK101에서의 aprE 발현은 각각 약 10배 빛 3배의 발현증가를 가져와 aprE 발현에 대한 포자변이주 및 전이상태 조절유전자의 독립적인 부가효과를 확인하였다.

• 한국경영과학회:학술대회논문집
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• 한국경영과학회 1996년도 추계학술대회발표논문집; 고려대학교, 서울; 26 Oct. 1996
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• pp.295-298
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• 1996

We consider a nonpreemptive single-machine scheduling problem to minimize the mean squared deviation(MSD) of job completion times about a common due date d with a maximum tardiness constraint, i.e., maximum tardiness is less than or equal to the given allowable amount, .DELTA.(MSD/T$_{max}$ problem). We classify the .DELTA.-unconstrained cases in the MSD/T$_{max}$ problem. We provide bounds to discern each case for the problem. It is also shown that the .DELTA.-unconstrained MSD/T$_{max}$ problem is equivalent to the unconstrained MSD problem and the tightly .DELTA.-constrained MSD/T$_{max}$ problem with n jobs and a maximum allowable tardiness .DELTA. can be converted into the constrained MSD problem with a common due date .DELTA. and n-1 jobs. Finally, the solution procedure for MSD/T$_{max}$ problem is provided. provided.

• Communications for Statistical Applications and Methods
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• 제16권5호
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• pp.841-849
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• 2009

Let {$X_n$, n ${\ge}$ 1} be a negatively associated sequence of identically distributed random variables with mean zeros and positive finite variances. Set $S_n$ = ${\Sigma}^n_{i=1}\;X_i$. Suppose that 0 < ${\sigma}^2=EX^2_1+2{\Sigma}^{\infty}_{i=2}\;Cov(X_1,\;X_i)$ < ${\infty}$. We prove that, if $EX^2_1(log^+{\mid}X_1{\mid})^{\delta}$ < ${\infty}$ for any 0< ${\delta}{\le}1$, then $\lim_{{\epsilon}\downarrow0}{\epsilon}^{2{\delta}}\sum_{{n=2}}^{\infty}\frac{(logn)^{\delta-1}}{n^2}ES^2_nI({\mid}S_n{\mid}\geq{\epsilon}{\sigma}\sqrt{nlogn}=\frac{E{\mid}N{\mid}^{2\delta+2}}{\delta}$, where N is the standard normal random variable. We also prove that if $S_n$ is replaced by $M_n=max_{1{\le}k{\le}n}{\mid}S_k{\mid}$ then the precise rate still holds. Some results in Fu and Zhang (2007) are improved to the complete moment case.

• Transactions on Electrical and Electronic Materials
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• 제5권5호
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• pp.173-179
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• 2004

The influence of heavily Si impurity doping in the GaN barrier of InGaN/GaN multi-quantum well structures of blue light emitting diodes were investigated by growing samples in metal-organic chemical vapor deposition. The delta-doped sample was compared to the sample with the undoped barrier. The delta-doped sample shows the tunneling behavior and forms the energy level of 0.32 eV for tunneling and the photoemission of the 450-nm band. The photo-luminescence shows the blue-shifted broad band of the radiative transition due to the inclusion of Si delta-doped layer indicating that the delta doping effect acts to form the higher energy level than that of quantum well. The dislocation may provide the carrier tunneling channel and plays as a source of acceptor. During the tunneling of hot carrier, there was no light emission.

• Archives of Pharmacal Research
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• 제18권5호
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• pp.308-313
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• 1995

This study has been undertaken to examine the acetylcholinesterase (AChE) of electric organ from korean electtric ray(Narke japonica). Korean electric ray was caughted at Chungmu sea and transported to the laboratory, where electric organs were removed and stored at $-70^{\circ}C$ until used. Acelycholinesterase(AChE) of electric organ was purified by affinity column that was prepared with dicaproyl-methylpyridinium linked to Sepharose 4B. Upon purification, the specific activities in Ellman unit were increased by 52 and 39 times for high salt soluble AChE (HSSE, 870.86 $\DeltaOD/min/geam$ of tissue) and detergent soluble AChE(DSE, 105.42 .$\DeltaOD/min/geam$ of tissue), respectively. Each subunit of AChE separated by SDS polyacrylamide gel electrophoresis(SDS-PAGE)was transferred to immonilon P by western boltting and detected by mAbs raised against each subunit of AChE from electric organ og Torpedo califomica. Collagenic tails of AChE from Torpedo califomica, likewise 103Kd protein of AChE from Narke japonica was detected by monoclonal antibody specific to 103Kd of AChE from Torpedo califomica. However, molar ratio of three subunits of AChE from Narke japonica is different from that of Torpedo calicormica. Furthermore, catalytic subunit of AChE from Narke japonica was not identified by monoclnal antibody specific to catalytic subunit of AChE from Torpedo californica. These results showed differences in molecular structure of AChE from Narke japonica and AChE from Torpedo califormica eventhough they showed same enzymatic activities.