• Bulletin of the Korean Chemical Society
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• 제33권6호
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• pp.2012-2016
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• 2012

A convenient synthetic route has been developed to synthesize 5-(4-((2-phenylthiazol-4-yl) methoxy)phenyl)-3-(4-sustituted phenyl)pyrazolines (5a-f) and 5-(4-((2-phenylthiazol-4-yl)methoxy)phenyl)-3-(4-substituted phenyl)isoxazolines (6a-f) starting from 2-phenyl-4-chloromethylthiazole (1). The chloromethylthiazole (1) was first condensed with 4-hydroxy benzaldehyde (2) for obtaining 4-((2-phenylthiazol-4-yl)methoxy)benzaldehyde (3). Claisen-Smidth condensation of 4-((2-phenylthiazol-4-yl)methoxy)benzaldehyde (3) and acetophenones has been carried in alkaline alcohol and obtained 3-(4-((2-phenylthiazol-4-yl)methoxy)phenyl)-1-(4-substituted phenyl)prop-2-en-1-ones (4a-f). The cyclocondensation of 2-propen-1-ones has been first time carried separately with hydrazine hydrate and hydroxylamine hydrochloride in aqueous micellar tetradecyltrimethylammonium bromide (TTAB) medium for getting the titled heterocycles with good to excellent yields.

• Bulletin of the Korean Chemical Society
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• 제25권7호
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• pp.991-996
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• 2004

New series of 6-(arylthio)uracils, 6-(4-substituted-1-piperazinyl)uracils, 2,4,5-trioxo-1H,3H-benzothiopyrano[2,3-d]pyrimidine and 5-aryl-2,4-dioxo-1H,3H-pyrimido[5,4-f]benzo[1,4]thiazepines have been prepared and screened for their in vitro activity against herpes simplex-1 virus (HSV-1) and human immunodeficiency virus-1 (HIV-1). The in vitro cytotoxic activity was also evaluated. The results of biological testing revealed that compound 5b showed marginal activity against HSV-1, while compounds 5b and 5f exhibited marginal activity against HIV-1. The rest of the tested compounds were found devoid of antiviral activity against both HSV-1 and HIV-1.

• 한국가축번식학회지
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• 제12권2호
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• pp.77-83
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• 1988

This study was done with mouse embryo to assess effects of freezing media containing sucrose, freezing metods(1-F, 0.3$^{\circ}C$/min;2-F, 3-5$^{\circ}C$/min;3-F, 15$^{\circ}C$min;4-F, LN2 vapour) and cell freezers on the embryo survival determined using the FDA test. The results are summarized as follows. 1. The FDA score obtained with 1, 2, 3 and 4-F was 3.8, 3.6, 3.2 and 3.2, respectively. There was a significant difference(P<0.05) between 1-F, 3-F and 2-F, 4-F. 2. The score at the morular stage(3.8) higher(P<0.005) than the blastocyst stage of embryos(3.2). 3. No difference (P>0.05) was found between the score obtained with a automatic embryo freezer(4.0) and a liquid nitrogen container(3.7).

• 대한한의학회지
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• 제31권4호
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• pp.20-37
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• 2010

Objective: This study was performed to investigate the effect of Yagwan-cheunghyeoltang (YCT) on insulin secretion in RIN-m5F cells. Methods: After treatment with various concentrations of YCT to RIN-m5F cells, cell viability, free radical-scavenging activity, SOD activity, and insulin secretion were measured. Additionally, insulin-related gene expressions were measured using real-time RT-PCR. Results: 1. YCT didn't show any influence on RIN-m5F cells viability. 2. YCT showed free radical-scavenging activity by 16% at $100{\mu}g/m{\ell}$ of concentration. 3. YCT showed enhancement of SOD activity by 60% at $100{\mu}g/m{\ell}$ of concentration. 4. YCT significantly increased insulin secretion in RIN-m5F cells in a dose-dependent manner. 5. YCT up-regulated INS-1, INS-2, IRS-1, IRS-2 and IRS-3 mRNA expressions compared to the control group. 6. YCT down-regulated INS-R, GCK, GLP-1R and GLP-2R mRNA expressions compared to the control group. Conclusion: YCT has pharmaceutical properties enhancing insulin production and controlling glucose-associated metabolism, and could be a candidate for drug development after further research.

• 통합자연과학논문집
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• 제12권4호
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• pp.101-104
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• 2019

A hydrated strontium iron fluoride, Sr₂Fe₂F₁₀(H₂O) has been synthesized and characterized. The material was synthesized through mild hydrothermal reaction using an aqueous CF₃COOH solution. The material exhibits a one-dimensional structure consisting of chains of corner-shared Fe³⁺F₆ octahedra, isolated Fe³⁺F₅(H₂O) octahedra, chains of SrF₁₀ polyhedra and isolated SrF₈ polyhedra, respectively. Magnetic property measurements on Sr₂Fe₂F₁₀(H₂O) reveals an antiferromagnetic order at T_N of ~2.5 K with a Weiss temperature (θ) of -61.51 K.

• 미생물학회지
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• 제36권4호
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• pp.259-266
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• 2000

아닐린분해능이 있는 Flavimonas oryzihabitans과 4-chlorobiphenyl (4-CBP)를 분해하는 Pseudomonas sp.를 원형질체 융합하여 아닐린과 4-CBP를 모두 분해하는 융합균주를 개발하고, 융합체의 특성을 조사하였다. F. oryzibhavitans는 융합체 선별표지 위애 NTG처리하여 chloramphenicol 내성 ($Cm^r$)을 유발하였다. Lysozyme-EDTA에 의한 각 모균주의 원형질체 생성율은 약 99%이었고, 원형질체의 재생율은 5.0~6.6%이었다. 원형질체는 40% PEG 6000을 사용하였을 때 효과적으로 융합이 이루어졌으며 융합율은 $3.16{\times}10^{-4} $이었다. 융합균인 F22의 DNA양는 모균주에 비해 약 2배 정도 증가 하였으며, 생화학적 특성은 모균주의 특성이 혼합하여 나타났다. F22는 5 mM 아닐린 최소배지에서는 모균주와 성장능과 분해능이 거의 비슷하였고, 10 mM 아닐린 최소배지에서는 1.5배 빠른 성장속도를 나타내었으나, 4-CBP 분해능은 모균주보다 약간 낮게 나타났다.

• Nuclear Engineering and Technology
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• 제51권3호
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• pp.792-799
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• 2019

The present study aims to investigate the fluorination of thorium oxide ($ThO_2$) by ammonium hydrogen difluoride ($NH_4HF_2$). Fluorination was performed at room temperature by mixing $ThO_2$ and $NH_4HF_2$ at different molar ratios, which was then left to react for 20 days. Next, the mixtures were analyzed using X-ray diffraction (XRD) at the intervals of 5, 10, 15, and 20 days, followed by the heating of the mixtures at $450-750^{\circ}C$ with argon gas flow. The characterization of $ThF_4$ was established using X-ray diffraction (XRD) and scanning electron microscopy-dispersion X-ray spectroscopy (SEM-EDX). In this study, ammonium thorium fluoride was synthesized through the fluorination of $ThO_2$ at room temperature. The optimum molar ratio in synthesizing ammonium thorium fluoride was 1.0:5.5 ($ThO_2:NH_4HF_2$) with 5 days reaction time. In addition, the heating of ammonium thorium fluoride at $450^{\circ}C$ was sufficient to produce $ThF_4$. Overall, this study proved that $NH_4HF_2$ is one of the fluorination agents that is capable of synthesizing $ThF_4$.

• 한국의류학회지
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• 제21권4호
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• pp.710-717
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• 1997

An investigation made of fabric strength & elongation and the lock stitch seam strength & elongation by stitch density (N1.5; 26 stitches/3 cm, N2.0; 19 stitches/3 cm, N2.5; 14 stitches/3cm) depending on methods of. sample prepariation (angle variations of unseamed sample and overlapping way of seamed sample) It found maximum stitch density that results of the seam strength test was highist in each angle of bias. The results obstained were as follows: 1. As the results of fabric strength and elongation tests as a function of angle of bias, breaking strength were that warp and weft angles (0$^{\circ}$, 90$^{\circ}$) were much higher than bias angles (20$^{\circ}$, 30$^{\circ}$, 45$^{\circ}$, 60$^{\circ}$) . And otherwise breaking elongation were that 45$^{\circ}$ angle of bias were highest and were that the warp & weft way were lower. 2. As the results of the seam strength tests by the stitch density under samples of same angles, the maximum stitch density were those; under 0$^{\circ}$/0$^{\circ}$, 60$^{\circ}$/60$^{\circ}$:F1, F2-N2.0, F3-N1.5, under 20$^{\circ}$/20$^{\circ}$, 30$^{\circ}$/30$^{\circ}$, 45$^{\circ}$/45$^{\circ}$: F1-N2.5, F2-N2.0, F3-N1.5, under 90$^{\circ}$/90$^{\circ}$: F1, F2, F3-N1.5. 3. As the results of the seam strength tests by the stitch density under samples of symmetry angles, the maximum stitch density were those; under 20$^{\circ}$/-20$^{\circ}$, 30$^{\circ}$/-30$^{\circ}$, 60$^{\circ}$/-60$^{\circ}$: F1, F3-N1.5, F2-N2.0, under 45$^{\circ}$/-45$^{\circ}$: F1, F2-N2.0, F3-N1.5.

• Food Science and Biotechnology
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• 제16권2호
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• pp.285-289
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• 2007

A 3% suspension of heat-stabilized defatted rice bran was treated with papain, followed by inactivating the enzyme by heat, and centrifuged. The supernatant was subjected to ultrafiltration, and fractions with various molecular sizes, F1 (>30 kDa), F2 (10-30 kDa), F3 (5-10 kDa), F4 (3-5 kDa), and F5 (3 kDa<), were freeze-dried, and evaluated for antimutagenicity by Ames test using Salmonella typhimurium TA 100 against phenazine methosulfate. The F3 fraction containing highest antimutagenicity from ultrafiltration was separated into 6 fractions by DEAE-Sephadex A-25 ion-exchange column chromatography (F3-1-F3-6). Each fractions having protein contents were pooled, dialyzed, freeze dried, and evaluated for antimutagenicity. Among the six fractions, the F3-1, F3-2, and F3-6 fractions showed antimutagenicity, which were 80.2, 53.4, and 58.6% at concentration of $100\;{\mu}g/plate$, respectively. These F3-1, F3-2, and F3-6 fractions were subjected to Sephadex G-50 gel filtration column chromatography for further purification. Among the purified fractions, the F3-1-1, F3-2-2, and F3-6-1 fractions showed antimutagenicity of 84.5, 58.6, and 69.8% at concentration of $100\;{\mu}g/plate$, respectively. It is thought that these peptides can find application for nutraceutical and pharmaceutical products.

• Archives of Pharmacal Research
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• 제25권5호
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• pp.600-607
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• 2002

Two series of 2,3-diarylcyclopent-2-ene-1-ones including 2-aryl-3-(2,5-dihydroxyphenyl)cyclopent-2-ene-1-ones (2a∼2f) and 3-aryl-2-(3',4',5'-trimethoxyphenyl)cyclopent-2-ene-1-one (3a∼3j) were synthesized and evaluated for the cytotoxicity against three tumor cell lines; B16F10, HCT116 and A431. It was found that the 3,4,5-trimethoxy substituent was optimal for the bioactivity of compounds in series 2. Meanwhile, compounds in series 3 exhibited the most potent cytotoxicity with 3-aryl ring being 4-methoxyphenyl (compound 3f), (3-hydroxy-4-methoxy)phenyl (compound 3e), or (3-amino-4-methoxy)phenyl (compound 3j).