• Nuclear Engineering and Technology
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• 제51권1호
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• pp.163-169
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• 2019

The robust controller synthesis and analysis of the water level process in the U-tube system generator (UTSG) is addressed in this paper. The parameter uncertainties of the steam generator (SG) are modeled as multiplicative perturbations which are normalized by designing suitable weighting functions. The relative errors of the nominal SG model with respect to the other operating power level models are employed to specify the weighting functions for normalizing the plant uncertainties. Then, a robust controller is designed based on ${\mu}$-synthesis and D-K iteration, and its stability robustness is verified over the whole range of power operations. A gain-scheduled controller with $H_{\infty}$-synthesis is also designed to compare its robustness with the proposed controller. The stability analysis is accomplished and compared with the previous QFT design. The ${\mu}$-analysis of the system shows that the proposed controller has a favorable stability robustness for the whole range of operating power conditions. The proposed controller response is simulated against the power level deviation in start-up and shutdown stages and compared with the other concerning controllers.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2001년도 춘계학술대회 논문집
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• pp.275-278
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• 2001

Research on the forced vibration control of a flexible GFR composite beam using $\mu$-synthesis is performed on this paper. Modal analysis method and modal coordinates are introduced to obtain the state equations of the structural system. Using these equations, Robust control algorithm using $\mu$-synthesis is adopted to suppress the forced vibration of a flexible beam since the designed controller can considered plant uncertainty and external disturbance. Constant disturbance which is generated by shaking the flexible beam as I's natural frequency is effectively rejected by a PZT actuator. Simulations and experiments are carried out with the designed controller and effectiveness of forced vibration suppression strategy is verified by results.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1998년도 제13차 학술회의논문집
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• pp.157-160
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• 1998

We argue that the combination of optimal control synthesis and QFT tuning enables design of controllers with levels of performance that surpasses what can be achieved using only a single technique. Using a constructive example, we demonstrate how the strength of each technique is utilized to arrive at a particularly desired controller in terms of tradeoffs between performance and controller complexity.

• 대한토목학회논문집
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• 제26권5A호
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• pp.849-859
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• 2006

본 연구에서는 벤치마크 사장교를 이용해 다양한 불확실성에 대해서 복합시스템에 사용된 ${\mu}$-제어기의 강인성 해석을 수행하였다. 복합 시스템에 추가적으로 사용된 능동제어 장치로 인하여 전체 시스템의 강인성이 저하되거나 불안정성이 발생할 수 있다. 따라서 본 연구에서는 복합 시스템의 강인성을 향상 시키기 위해 기본적으로 신뢰성이 확보되는 수동장치와 함께 불확실성을 포함한 시스템의 성능과 안정성(강인성능)을 보장하는 ${\mu}$-합성법을 능동제어 장치에 사용하였다. 교량상판에 추가적인 질량, 구조물 강성행렬에 대한 섭동, 능동제어 장치의 시간지연, 그리고 이들의 조합을 이용하여 ${\mu}$-합성법의 강인성을 조사하였다. 수치해석 결과 다양한 불확실성에 대해 제안된 시스템은 제어성능의 저하 없이 뛰어난 강인성을 보여 주었다. 또한 제어시스템의 강인성은 다른 불확실성에 비해 구조물의 강성행렬 섭동에 더 큰 영향을 받는다. 따라서 ${\mu}$-합성법으로 제어되는 복합 시스템은 불확실성이 많은 지진하중을 받는 사장교에 개선된 제어기법으로 제안될 수 있다.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2004년도 추계학술대회논문집
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• pp.574-577
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• 2004

This paper presents a hybrid system combining lead rubber bearings and hydraulic actuators controlled by a $\mu-synthesis$ method for seismic response control of a cable-stayed bridge. A hybrid system could alleviate some of restrictions and limitations that exist when each system is acting alone because multiple control devices are operating. Therefore, the overall control performance of a hybrid system may be improved compared to each system, however the overall system robustness may be negatively impacted by active device in the hybrid system or active controller may cause instability due to small margins. Therefore, a $\mu-synthesis$ method that guarantees the robust performance is considered to enhance the possibility of real applications of the control system. The performances of the proposed control system are compared with those of passive, active, semiactive control systems and hybrid system controlled by a LQG algorithm. Furthermore, an extensive robust analysis with respect to stiffness and mass matrices perturbation and time delay of actuator is performed. Numerical simulation results show that the performances of the proposed control system are superior to those of passive system and slightly better than those of active and semiactive systems and two hybrid systems show similar control performances. Furthermore, the hybrid system controlled by a f-synthesis method shows the good robustness without loss of control performances. Therefore, the proposed control system could effectively be used to seismically excited cable-stayed bridge which contains many uncertainties.

• 대한한의학회지
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• 제23권4호
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• pp.45-54
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• 2002

Objectives: In order to investigate the relationship of Radix Trichosanthis components and the melanin synthesis, the author has analyzed the cell viability and tyrosinase activity, melanin content and morphologic changes in n-hexane, EtOAc, n-BuOH, and H2O fraction. Methods: At first, in order to determine the concentration of the Radix Trichosanthis component, the author investigated the viability of B16 melanoma cell. To measure the effects of Trichosanthes kirilowii extracts (n-BuOH, n-Hexane, EtOAc, H2O fractions) on the viability of A549 cells, A549 cells were treated with various concentrations (from 0.5 to $25{\;}\mu\textrm{g}/ml$) of components of Trichosanthes kirilowii. After 24hrs, the cell viability was measured by MTT assay. The EtOAc components of Trichosanthes kirilowii decreased the viability of A549 cells in a dose-dependent manner. H2O and n-BuOH components had no cell toxicity till $25{\;}\mu\textrm{g}/ml$, the n-hexane component showed minor cell toxicity at $25{\;}\mu\textrm{g}/ml$ and the EtOAc component cell toxicity was revealed at $5{\;}\mu\textrm{g}/ml$ concentration. Results: 1. The results of tyrosinase activity and the Radix Trichosanthis component; n-hexane and EtOAc components controlled it effectively; the n-BuOH components were less effective. 2. The results of melanin content analysis showed that the n-hexane and EtOAc components effectively inhibited, the n-BuOH fraction inhibited less, and H2O component didn't inhibit the terminal melanin formation. 3. In the n-BuOH and H2O component there were no changes, but in the n-hexane component the melanin content was effectively inhibited. 4. In the EtOAc fraction, although the melanin content was inhibited, the cell count was evidently suppressed, Of all of the Radix Trichosanthis components, the n-Hexane and EtOAc fractions inhibited the melanin synthesis best, but owing to its toxicity, the EtOAc components inhibited the cell count. Conclusion: The above results demonstrated that Radix Trichosanthis n-hexane fraction efficiently inhibited the tyrosinase activity and melanin synthesis.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 2004년도 가을 학술발표회 논문집
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• pp.476-483
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• 2004

This paper presents a hybrid system combining lead rubber bearings and hydraulic actuators controlled by a μ-synthesis method for seismic response control of a cable-stayed bridge. A hybrid system could alleviate some of restrictions and limitations that exist when each system is acting alone because multiple control devices are operating. Therefore, the overall control performance of a hybrid system may be improved compared to each system, however the overall system robustness may be negatively impacted by active device in the hybrid system or active controller may cause instability due to small margins. Therefore, a f-synthesis method that guarantees the robust performance is considered to enhance the possibility of real applications of the control system. The control performances of the proposed control system are compared with those of passive, active, semiactive control systems and hybrid system controlled by LQG algorithm and an extensive robust analysis with respect to stiffness and mass matrices perturbation and time delay of actuator is performed. Numerical simulation results show that the control performance of the proposed control system is superior to that of the passive system and slightly better than that of the active and semiactive systems and two hybrid systems show similar control performances. Furthermore, the hybrid system controlled by a μ-synthesis method shows the good robustness without loss of control performances. Therefore, the proposed control system could effectively be used to seismically excited cable-stayed bridge which contains many uncertainties.

• Journal of Acupuncture Research
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• 제23권2호
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• pp.91-102
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• 2006

Objectives : Ulmus davidiana Planch (UD) has long been known to have anti-inflammatory and protective effects on damaged tissue, inflammation and bone among other functions. Methods : This study was undertaken to address whether the water extract of the bark of UD could modulate proliferation of mouse osteoclasts in vitro and to investigate its effect on cyclooxygenase-2 (COX-2), which converts arachidonic acid to prostaglandin E2 (PGE2) and is highly expressed in osteoclasts. Mouse osteoclasts were tested in vitro for growth inhibition, proliferation cell nuclear antigen expression, and COX-2 activity and expression after treatment with UD extract. Results : Its effects were compared with those of indomethacin (a nonselective COX inhibitor) and celecoxib (a selective COX-2 inhibitor) by Cell viability assay, Cell cycle analysis, Immunohistochemical analysis of PCNA expression, Western blot analysis and PGE2 Enzyme immunoassay (EIA). UD demonstrated a strong growth inhibitory action in both tested osteoclasts cells. The IC50s were $10\;{\mu}g/ml$ for UD, $6\;{\mu}M$ for celecoxib and $42\;{\mu}M$ for indomethacin. UD, as well as celecoxib and indomethacin, suppressed proliferation cell nuclear antigen expression and PGE2 synthesis in osteoclasts. UD inhibited COX-2 expression, whereas celecoxib inhibited COX-2 activity directly. Conclusion : UD selectively and effectively inhibits osteoclasts cell growth in vitro. Inhibitory action of PGE2 synthesis via suppression of COX-2 expression may be responsible for its anti-inflammatory activity.

• 생명과학회지
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• 제28권8호
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• pp.908-916
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• 2018

모발의 검정색은 노화됨에 따라 백색으로 변화된다. 이러한 현상은 모낭내 tyrosinase 활성의 감소와 $H_2O_2$에 의한 축적에 의하여 기인된다. 따라서 본 연구의 목적은 현미주정추출물(OREE)를 이용하여 백발화의 원인인 과산화 수소에 대한 항산화 활성과 멜라닌 생성 촉진 효과를 조사한 것이다. 본 연구에서 OREE은 낮은 DPPH radical 소거능과 환원력을 보여주었다. 그러나 B16F1 세포내에서 $H_2O_2$ 소거에 대해서는 높은 항산화효과를 나타내었다. 그리고 OREE는 in vitro에서 DOPA 산화 활성은 나타나지 않았지만 $64{\mu}g/ml$에서 tyrosinase 활성을 증가시켰다. MTT assay에서 OREE는 $32{\mu}g/ml$ 이상의 농도에서 세포독성을 나타내었다. 또한 OREE는 $8{\mu}g/ml$ 이상의 농도에서 멜라닌 합성은 농도에 비례하여 증가하였고, $H_2O_2$로 멜라닌 생성을 저하시킨 세포에서도 멜라닌 합성을 증가시켰다. 멜라닌 합성에 대한 OREE의 효과를 확인하기 위하여 Western blot 분석이 수행되었다. $H_2O_2$로 멜라닌 생성을 저하시킨 세포에서 멜라닌 합성 기전 관여하는 tyrosine hydroxylase와 tyrosinase-related protein-2 (TRP-2) 발현은 OREE의 존재 하에서 증가하였다. 이상의 발견들은 OREE가 멜라닌 합성을 촉진시킬 수 있어 이와 관련된 모발화장품의 개발에 적용시킬 수 있다는 것을 시사하고 있다.

• 한국가축번식학회지
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• 제21권4호
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• pp.325-333
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• 1997

Recent evidence indicates that growth factors modulate response of mammary epithelial cells to environmental stress. The objective of this study was to examine the cellular and biochemical responses of mammary tissue to environmental stress caused by artificial mastitis. For experimental a, pp.oach, toxins of most mastitis causing organisms(Staph. aureus or Strep. agalactiae) and heat stress(42$^{\circ}C$) were artificially exposed to mammary tissue. Effects of these environmental stresses on cell growth, cell death and heat shock protein synthesis were examined. Lactating mammary tissure were cultured under basal medium(DMEM) su, pp.emented with insulin(10$\mu\textrm{g}$/ml) and aldosterone(1$\mu\textrm{g}$/ml). All treatment groups in heat stress at 42$^{\circ}C$ incubation significantly decreased DNA synthesis rates in comparison with those at 39$^{\circ}C$(P<0.05), however, these decreased DNAa synthesis rates were recovered by addition of adenosine(10$\mu$M) and IGFI(10ng/ml). Similar results were obtained when tissue growth rates were measured by DNA content/tissue. Strep. agalactiae toxin did not significantly decreased DNA content/tissue in comparison with no treatment of bacterial toxin with or without heat stress, however, tended to decrease DNA contents/tissue without heat stress. In the fluorography analysis, heat stress(42$^{\circ}C$ incubation) slightly increased 35S-methoionine labelled 70kd protein synthesis. These results indicate that environmental stress caused by artificial mastitis slightly decreased mammary growth or mammary size, however, these results could be recovered by addition of adenosine and IGF-I.