• Journal of the Korean Society for Aeronautical & Space Sciences
• /
• v.42 no.7
• /
• pp.535-543
• /
• 2014

A computational simulation for a nonslender BWB UCAV configuration with rounded leading edge and span of 1.0m was performed to analyze its aerodynamic characteristics. The freestream is 50m/s over -4 to 26 degree A.o.A.s. Reynolds number based on the mean chord length is $1.25{\times}10^6$. 3D multi block hexahedral grids are used which allow good grid quality and ease to capture boundary layer. ${\gamma}-Re_{\theta}$ model as well as $k-{\omega}$ SST model is employed to assess the effect of transition for flow behavior. Drag and lift of the UCAV were well predicted while $C_M$ is under predicted at high angle of attacks and influenced by the turbulence models strongly. After assessing pressure distribution, skin friction lines and velocity field around the UCAV configuration, it was found that transition effect should be considered to enhance the prediction of aerodynamic behavior by a vortical flowfield.

• The Korean Journal of Physiology and Pharmacology
• /
• v.16 no.4
• /
• pp.231-236
• /
• 2012

We studied the effects of acetylcholinesterase inhibitors, donepezil and galantamine, and an N-methyl-D-aspartate (NMDA) receptor blocker, memantine, on sleep-wake architecture in rats. Screw electrodes were chronically implanted into the frontal and parietal cortex for the electroencephalography (EEG). EEG was recorded with a bio-potential amplifier for 8 h from 09:30 to 17:30. Vibration was recorded to monitor animal activity with a vibration measuring device. Sleep-wake states such as wake (W), slow-wave sleep (S) and paradoxical or rapid eye movement sleep (P), were scored every 10 sec by an experimenter. We measured mean episode duration and number of episode to determine which factor sleep disturbance was attributed to. Donepezil and memantine showed a significant increase in total W duration and decreases in total S and P duration and delta activity. Memantine showed increases in sleep latency and motor activity. Changes of S and P duration in memantine were attributed from changes of mean episode duration. Galantamine had little effect on sleep architecture. From these results, it is showed that galantamine may be an anti-dementia drug that does not cause sleep disturbances and memantine may be a drug that causes severe sleep disturbance.

• The Korean Journal of Pain
• /
• v.23 no.2
• /
• pp.99-108
• /
• 2010

Chronic pain is a multifactorial condition with both physical and psychological symptoms, and it affects around 20% of the population in the developed world. In spite of outstanding advances in pain management over the past decades, chronic pain remains a significant problem. This article provides a mechanism- and evidence-based approach to improve the outcome for pharmacologic management of chronic pain. The usual approach to treat mild to moderate pain is to start with a nonopioid analgesic. If this is inadequate, and if there is an element of sleep deprivation, then it is reasonable to add an antidepressant with analgesic qualities. If there is a component of neuropathic pain or fibromyalgia, then a trial with one of the gabapentinoids is appropriate. If these steps are inadequate, then an opioid analgesic may be added. For moderate to severe pain, one would initiate an earlier trial of a long term opioid. Skeletal muscle relaxants and topicals may also be appropriate as single agents or in combination. Meanwhile, the steps of pharmacologic treatments for neuropathic pain include (1) certain antidepressants (tricyclic antidepressants, serotonin and norepinephrine reuptake inhibitors), calcium channel ${\alpha}2-{\delta}$ ligands (gabapentin and pregabalin) and topical lidocaine, (2) opioid analgesics and tramadol (for first-line use in selected clinical circumstances) and (3) certain other antidepressant and antiepileptic medications (topical capsaicin, mexiletine, and N-methyl-d-aspartate receptor antagonists). It is essential to have a thorough understanding about the different pain mechanisms of chronic pain and evidence-based multi-mechanistic treatment. It is also essential to increase the individualization of treatment.

• Journal of Microbiology and Biotechnology
• /
• v.21 no.5
• /
• pp.503-508
• /
• 2011

A ${\beta}$-glucosidase from Phoma sp. KCTC11825BP isolated from rotten mandarin peel was purified 8.5-fold with a specific activity of 84.5 U/mg protein. The purified enzyme had a molecular mass of 440 kDa with a subunit of 110 kDa. The partial amino acid sequence of the purified ${\beta}$-glucosidase evidenced high homology with the fungal ${\beta}$- glucosidases belonging to glycosyl hydrolase family 3. Its optimal activity was detected at pH 4.5 and $60^{\circ}C$, and the enzyme had a half-life of 53 h at $60^{\circ}C$. The $K_m$ values for p-nitrophenyl-${\beta}$-D-glucopyranoside and cellobiose were 0.3 mM and 3.2 mM, respectively. The enzyme was competitively inhibited by both glucose ($K_i$=1.7 mM) and glucono-${\delta}$-lactone ($K_i$=0.1 mM) when pNPG was used as the substrate. Its activity was inhibited by 41% by 10 mM $Cu^{2+}$ and stimulated by 20% by 10 mM $Mg^{2+}$.

• Journal of Welding and Joining
• /
• v.10 no.4
• /
• pp.230-239
• /
• 1992

The specimens of two base metals and material friction-welded with hetrogeneous steels of SM40C and STS304 have been prepared and the characteristics of rupture and crack propagation of them have been examined. In the friction-welded material, the width of HAZ is 3.0mm for STS304 and 3.4mm for SM40C. The hardness distribution in HAZ of SM40C is decreased gradually as being getting off interface, but that in HAZ of STS304 is decreased remarkedly and the value of hardness becomes a little lower than that of the base metal in region of 1mm from interface and becomes a little higher than that of the base metal. The tensile strength of the friction-welded material appeared a little lower than that of the base metal and rupture by tensile load is developed in HAZ of STS304 and the position of rupture is at region of low hardness(1mm from interface). The crack propagation rates(da/dN) in both HAZ of the friction-welded material are a little higher than those in both base metals, but the difference are less except for the case of SM45C in low .DELTA. K value. It has been ascertained that the crack in the interface propagates selectively along the HAZ of SM40C and consequently the crack propagation rate is almost similar to that in the HAZ of SM40C.

• Clinical and Experimental Reproductive Medicine
• /
• v.20 no.2
• /
• pp.117-123
• /
• 1993

The condition of the endometrium is an important factor which may influence the success or failure in IVF-ET. This study was undertaken for evaluation of the value of endometrial growth as an early predictor for the success of IVF. Ultrasonographic endometrial measurement were performed in 43 IVF cycles that conceived, 101 cycles that did not with an IVF-ET There was no significant difference in the endometrial thickness and the serum concentration of estradiol in the pregnant versus nonpregnant group(10.4 vs. 9.9 mm: 2348 vs. 2017 pg/ml no hCG administration day). No correlation was found between the ultrasound image and serum estradiol levels around the time of hCG administration(r=0.54, p=0.13 no Day 2; r=0.45, p=0.14 no Day 1). The duration of gonadotropin treatment, number of follicles, number of oocytes retrieved, and fertilization rate were not statistically different in the two groups, however, there was a significant difference in the number of embryos in the pregnant versus nonpregnant group)p< 0.05). A higher pregnancy rate and ongoing pregnancy rate occured with an endometrial thickness over 11 mm compared with below 7mm(p< 0.05, p< 0.005). however, no significant differences were noted in the implantation rate and abortion rate among the groups that classified according to their endmetrial thickness. The endometrial growth(${\Delta}$) from hCG administration day(DO) to D6 was greater in the women who achieved pregnancy than in the nonpregnant group(p< 0.01). There were no significant differences in serum estradiol levels, implantation rate, pregnancy rate, and abortion rate among the groups that classified according to the pattern of echogenesity of endometrium, however, significantly higher ongoing pregnancy rate was noted in group A, B compared with group C.(p< 0.0001, p< 0.001) These results suggest that there were no ultrasonographically detectable differences in the patterns of endometrial growth and development around the time of hCG administration in patients who conceive versus those that do not in IVF-ET.

• The Journal of Advanced Prosthodontics
• /
• v.5 no.3
• /
• pp.296-304
• /
• 2013

PURPOSE. The aim of this study was to evaluate the effect of polishing and glazing on the color and spectral distribution of monolithic zirconia. MATERIALS AND METHODS. Forty-five monolithic zirconia specimens ($16.3mm{\times}16.4mm{\times}2.0mm$) were fabricated and divided into 5 groups according to the number of A2-coloring liquid applications (Group I to V). Each group was divided into 3 subgroups according to the method of surface treatments (n=3): N: no treatment; P: polishing; G: glazing. Color and spectral distribution of five different areas of each specimen were measured according to CIELAB color space in the reflectance mode relative to the standard illuminant D65 on a reflection spectrophotometer. Data were analyzed using one-way ANOVA followed by Tukey's HSD test, Pearson correlation and regression analysis (${\alpha}$=.05). RESULTS. There was a significant difference in CIE $L^*$ between Subgroup N and P, and in CIE $b^*$ between Subgroup P and G in each group. Spectral reflectance generally decreased in Subgroup P and G in comparison with Subgroup N. Color differences between Subgroup P and G were within the perceptibility threshold (${\Delta}E{^*}_{ab}$ < 3.7) in most groups. Highly significant correlation was found between CIE $b^*$ and each subgroups as the number of coloring liquid applications increased ($R^2$ >0.88, P<.001). CONCLUSION. A perceptible color difference can be detected after polishing of monolithic zirconia. Polishing decreases the lightness, and glazing also decreases the lightness, but increases the yellowness of monolithic zirconia.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
• /
• v.25 no.4
• /
• pp.387-392
• /
• 2014

In this paper, the broadband antenna design, which can be applied to USB Dongle, supporting Wibro(2.3~2.4 GHz), Wi-Fi(2.4~2.5 GHz) and LTE7(2.5~2.7 GHz) is proposed technique. The proposed antenna was designed similar to PIFA type antennas. Reactive elements were used to control the input impedance and wideband characteristics were achieved by controlling coupling between the feed structure and the radiator. As a result, the antenna printed on FR-4 PCB(${\epsilon}_r$ =4.4, tan ${\delta}$=0.02) occupying an area of $15{\times}5mm^2$ was able to achieve bandwidth of 1 GHz from 2.1 to 3.1 GHz under VSWR=2. Measured return loss characteristics, bandwidth and radiation patterns were in good agreement with the simulated results.

• Journal of the Korean earth science society
• /
• v.28 no.4
• /
• pp.491-496
• /
• 2007

We performed R band time-series CCD photometric observations of the 55 Pandora for 2 nights using the 0.6 m telescope equipped with 2K CCD camera at SOAO (Sobaeksan Optical Astronomical Observatory). From the observation we determined its rotation period $P=0.^d2007=4.^h8168$, and maximum amplitude $0.281\;{\pm}\;0.001$. We also derived the pole position ${\lambda}_p(^o)=342$, ${\beta}_p(^o)=64$, and the shape parameter a/b = 1.27, b/c = 1.31 by applying Amplitude-Magnitude method.

• Journal of Periodontal and Implant Science
• /
• v.25 no.3
• /
• pp.487-496
• /
• 1995

Previous studies have demonstrated that not all A. actinomycetemcomitans produced significant level of leukotoxic factor and its leukotoxicity have associated with serotype and genetic variation. Our aim was to investigate on the interrelationship between serotype and leukotoxicity of an A. actinomycetemcomitans consisting of 13 clinically well characterized. Korean isolates and to evaluate if particular virulent clonal types of A. actinomycetemcomitans are associated with periodontal disease. For this study, 13 strains of A. actinomycetemcomitans from 6 patients with periodontal disease were isolated and identified by using a selective medium(tryptic soy agar supplemented with 10% serum, $75{\mu}g$ of bacitracin and $5{\mu}g$ of vancomycin per ml) in 10% C02 incubator for 3days with routine Gram staining, colony morphology and biochemical test..For serotyping, antisera were prepared from reference strains of 5 serotypes. (ATCC 29523,Y4, SUNY aB 67, IDH 781, IDH 1705) and then ammonium sulfate precipitation, immunoabsorption and indirect immunofluoroscent procedures were done. For analysis of leukotoxicity, sonic extract of A. actinomycetemcomitans exposed to PMN, and trypan blue was stained for counting the cell viability. Finally Southern blot analyses of genomic DNA digested with the restriction enzyme Tag I was done and the Southern blots were hybridized with the 530bp fragment, termed delta 530, originating from the ltx promoter of strain 652 and deleted from strain JP2. Also ltxA-3.1 and SC2 probe from strain JP2 were hybridized with genomic DNA fragments. Results reveal that strains isolated showed approximately equal proportions of 3 serotypes(b, d, e) and serotype b was not detected. 2 patients harbored 2 different serotypes in the same disease site. The prevalence of leukotoxic strain was 23% and there was no relationship between serotype, leukotoxicity and clinical observations. Especially virulent clonal types of Actinobacillus actinomycetemcomitan (JP2 strain) could not found. Further studies are necessary on the genetic polymorphism of leukotoxin and its relations to clinical status.