• Bulletin of the Korean Chemical Society
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• v.26 no.1
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• pp.97-102
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• 2005

The addition reactions of $\alpha$,$\alpha$-difluoroiodomethyl n-butyl ketone, α,α-difluoroiodomethyl cyclohexyl ketone, or $\alpha$,$\alpha$-difluoroiodomethyl phenyl ketone to alkenes were successfully accomplished in good yields in the presence of copper powder. The reaction was also applicable to alkenes containing a variety of functional groups such as ester, trimethylsilyl, or ether group. Acetonitrile was determined to be the best solvent in the present study and the reaction was performed at 55 ${^{\circ}C}$ for 15-22 h. This reaction provides a new, efficient and general method for the synthesis of $\alpha$,$\alpha$-difluoro functionalized ketones.