• Rapid Communication in Photoscience
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• v.1 no.2
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• pp.61-61
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• 2012

• Journal of Gastric Cancer
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• v.20 no.2
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• pp.202-211
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• 2020

Purpose: This study was to investigate the prognostic significance of the preoperative fibrinogen and systemic inflammation response index (F-SIRI) in a Chinese cohort of resectable gastric cancer. Materials and Methods: Baseline characteristics, preoperative fibrinogen levels and peripheral neutrophil, monocyte, and lymphocyte counts were retrospectively reviewed in 240 patients who underwent radical gastrectomy. The optimal cut-off values for fibrinogen and SIRI were defined as 4.0 g/L and 1.2. Then patients with hyperfibrinogenemia (≥4.0 g/L) and high SIRI (≥1.2) were assigned with an F-SIRI of 2 (both of these hematological abnormalities), 1 (one of these abnormalities), and 0 (neither abnormality), respectively. The prognostic value was examined by univariate and multivariate survival analysis. Results: Preoperative F-SIRI was significantly correlated with tumor size, fibrinogen level, and adjuvant chemotherapy. Whereas there was no significant difference in age, gender, tumor location or other characteristics between groups. In addition, high preoperative F-SIRI was significantly associated with worse disease-free survival (DFS) (hazard ratio [HR], 2.299; 95% confidence interval [CI], 1.482-3.566; P<0.001) and overall survival (OS) (HR, 2.461; 95% CI, 1.584-3.824; P<0.001) by univariate survival analysis. Moreover, it remained an independent predictor for impaired DFS (HR, 2.023; 95% CI, 1.273-3.215; P=0.003) and OS (HR, 2.341; 95% CI, 1.480-3.705; P<0.001) in multivariate Cox regression analysis. Conclusions: Preoperative F-SIRI could serve as a significantly prognostic marker for long-term survival in Chinese patients who underwent radical gastrectomy.

• Journal of the Korea Convergence Society
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• v.13 no.2
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• pp.341-348
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• 2022

The study was aimed to identify the educational needs for gerontological nursing using the nursing diagnosis classification of hospital nurses. A cross-sectional survey was conducted on 245 nurses who had experience caring for older patients within 1-year at two nurse web cafes. As a result of the study, 43 nursing diagnoses were classified into 6 areas: acute care, daily life care, education and counseling, environment and resource management, health promotion, and geriatric disease management. Nursing educational needs differed according to the age, sex, marital status, education level, size of the hospital, and working experience of the nurse. In order to effectively perform nursing care for the elderly and geriatric patients, it may be necessary to investigate the needs of continuous education and develop a detailed education program.

• Journal of Mechanical Science and Technology
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• v.18 no.11
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• pp.1932-1940
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• 2004

Although the previous researches evaluated the fatigue behavior of Al/GFRP laminates using the traditional fracture mechanism, their researches were not sufficient to do it : the damage zone of Al/GFRP laminates was occurred at the delamination zone instead of the crack-metallic damages. Thus, previous researches were not applicable to the fatigue behavior of Al/GFRP laminates. The major purpose of this study was to evaluate delamination behavior using the relationship between crack length (a) and delamination width (b) in Al/GFRP laminate. The details of investigation were as follows: 1) Relationship between the crack length (a) and the delamination width (b), 2) Relationship between the delamination aspect ratio (b/a) and the delamination area rate ((A$\_$D/)/subN// (A$\_$D/)$\_$All/), 3) The effect of delamination aspect ratio (b/a) on the delamination shape factor (f$\_$s/) and the delamination growth rate (dA$\_$D// da). As results, it was known that the delamination aspect ratio (b/a) was decreased and the delamination area rate ((A$\_$D/)$\_$N// (A$\_$D/)$\_$All/) was increased as the normalized crack size (a/W) was increased. And, the delamination shape factors (f$\_$s/) of the ellipse-II(f$\_$s3/) was greater than of the ellipse-I(f$\_$s2/) but that of the triangle (f$\_$s1/) was less than of the ellipse-I(f$\_$s2/).

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.26 no.1
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• pp.1-18
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• 2013

Objective: Recently the demands for the effective and safe depigmentative and anti-aging agents of the skin have increased due to the medical, pharmaceutical and cosmetic reasons. The purpose of this study is to investigate the MKG(Methanol Extract of Kaempferia galanga) and their dermal bioactivity properties related to cosmeceuticals such as depigmentation. Methods: We assessed inhibitory effects of MKG on melanin production in B16/F10 melanoma cells, on mushroom tyrosinase activity, effects of MKG on the expression tyrosinase, TRP-1, TRP-2, GSK-$3{\beta}$, CREB, MITF in B16/F10 melanoma cells without cytotoxicity range. Cell viability was measured by MTT assay and tyrosinase activity was assessed using by DOPA staining, western-blot analysis. We measured inhibition of melanin synthesis and tyrosinase activity by down-regulation of melanogenic enzyme expressions in ${\alpha}$-MSH induced melanogenesis B16/F10 melanoma cells. Results: MKG inhibited tyrosinase-activity, total melanin contents and dendrite out-growth. MKG inhibited melanogenesis by down-regulation of tyorsinase, TRP-1, TRP-2, CREB, and MITF in B16/F10 cells. The treatment with MKG at the 12.5, $25{\mu}g/ml$ level significantly inhibited the melanin synthesis induced ${\alpha}$-MSH in B16/F10 melanoma cells compared with untreated control. Conclusion: These results suggest that MKG inhibit melanin biosynthesis which is involved in hyper-pigmentation. So MKG is considered to be used as a whitening components reducing cytotoxicity.

• Journal of Biomedical Engineering Research
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• v.42 no.6
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• pp.268-276
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• 2021

Functional near-infrared spectroscopy-based brain-computer interface (fNIRS-based BCI) has been receiving much attention. However, we are practically constrained to obtain a lot of fNIRS data by inherent hemodynamic delay. For this reason, when employing machine learning techniques, a problem due to the high-dimensional feature vector may be encountered, such as deteriorated classification accuracy. In this study, we employ an elastic net-based feature selection which is one of the embedded methods and demonstrate the utility of which by analyzing the results. Using the fNIRS dataset obtained from 18 participants for classifying brain activation induced by mental arithmetic and idle state, we calculated classification accuracies after performing feature selection while changing the parameter α (weight of lasso vs. ridge regularization). Grand averages of classification accuracy are 80.0 ± 9.4%, 79.3 ± 9.6%, 79.0 ± 9.2%, 79.7 ± 10.1%, 77.6 ± 10.3%, 79.2 ± 8.9%, and 80.0 ± 7.8% for the various values of α = 0.001, 0.005, 0.01, 0.05, 0.1, 0.2, and 0.5, respectively, and are not statistically different from the grand average of classification accuracy estimated with all features (80.1 ± 9.5%). As a result, no difference in classification accuracy is revealed for all considered parameter α values. Especially for α = 0.5, we are able to achieve the statistically same level of classification accuracy with even 16.4% features of the total features. Since elastic net-based feature selection can be easily applied to other cases without complicated initialization and parameter fine-tuning, we can be looking forward to seeing that the elastic-based feature selection can be actively applied to fNIRS data.

• Archives of Pharmacal Research
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• v.18 no.6
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• pp.415-422
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• 1995

Twenty-four flavones were synthesized with various hydroxyl and/or methoxyl groups on A and B rings. Their antimutagenic properties were evaluated against ben:w(a)pyrene (BaP) and a pool of mutagenic urine concentrate (U) using a modified liquid incubation method of Ames test. The tester strain was Salmonella typhimurium TA98+S9 Mix. The antimutagenic activities were calculated by non linear regression analysis and the doses of flavones (in nmoles) required for a 50% reduction of induced revertants with BaP and U were defined as the inhibition doses (TEX>$ID_{508}{\;}and{\;}ID_{508}$ respectively). Seventeen flavones possessed significant antimutagenic activity against BaP. $ID_{508}$ ranged from 15.1 nmoles (F22) to 1000.6 nmoles (F13). Eighteen f1avones showed significant antimutagenic activity against U. $ID_{50U}$ ranged from 23.5 nmoles (F22) to 354.6 nmoles (F3). The 2',3',4'-trihydroxyflavone (F22, $ID_{508}=15.1$ nmoles, $ID_{50U}=23.5$ nmoles) and the 2',3',4',7-tetrahydroxyflavone (F20, $ID_{508}=37.8$ nmoles; $ID_{50U}=62.3$ nmoles) had antimutagenic activities similar to those of chlorophyllin ($ID_{508}=19.6$ nmoles and $ID_{50U}=44.2$ nmoles) and were evaluated against B(alP 7,8-dihydrodiol-9,10-epoxide. Against this last mutagen, the flavones which included three OH in B ring showed the highest activity and this property seemed independent of the substituent groups on A ring.

• KSBB Journal
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• v.18 no.6
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• pp.529-535
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• 2003

We studied degradation effects of hydrophobic substrate such as kerosene and diesel by adding a biosurfactant originated from Pseudomonas aeruginosa F722 and chemical surfactants (Tween 80 and detergent) with aeration. The surface tensions of the biosurfactant, Tween 80 and detergent were 30mN/m, 39mN/m and 31mN/m, respectively. When the concentration of biosurfactant added in C-medium was 0.01 and 0.15%(w/v), the ratios of hydrocarbon degradation were 94.3％ and 94.2% respectively. It was 6.2%(w/v) higher than when the concentrations of added biosurfactant were 0.05, 0.1 and 0.2％. The degradation ratios of the chemical surfactants (Tween 80 and detergent) were 94.5％ and 93.5％ respectively. The effects of the biosurfactant and chemical surfactants were similar on the degradation ratio in mixtures of kerosene and diesel. However, the population of viable p. aeruginosa F722 at the end of the cultivation period was twice as higher in the biosurfactant than that in the chemical surfactant. We also studied the effect of aeration (0.5vvm) on the degradation ratio. The biosurfactant addition experiment was conducted with 0.5vvm air, 35$^{\circ}C$, 150rpm, pH 8.0, 3days, 1.0% (w/v) substrate. When p. aeruginosa F722 and 0.15%(w/v) biosurfactant were added, the degradation ratio of hydrocarbon was 94.8％. Without p. aeruginosa F722, it was 68%. Thus, with aeration, the degradation ratio of hydrocarbon was increased by 26.8％. In addition, the cultivation time was shortened by 1/3. The degradation ratios of hydrocarbon in shaking culture (cultivation time; 3days) and stationary culture (cultivation time; 10days) were 94.8 and 93.7％ respectively. Thus, the addition of biosurfactant and aeration enhanced the degradation of hydrocarbon originated kerosene and diesel.

• Journal of Physiology & Pathology in Korean Medicine
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• v.25 no.2
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• pp.345-351
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• 2011

This study was to examine the positive and negative affect related to psychological characteristics of each Sasang types using Positive and Negative Affect Schedule (PANAS) with 78 students from School of Korean Medicine, Pusan National University. After determining the Sasang types by QSCC II, the psychological characteristics of each Sasang types were analysed by PANAS. We did ANOVA analysis with eight related scales and found significant differences between the Tae-Eum type ($18.71{\pm}8.75$, $6.47{\pm}3.36$, $6.31{\pm}2.47$, $3.18{\pm}2.77$, $10.94{\pm}10.08$) and the So-Eum type ($13.38{\pm}6.03$, $4.55{\pm}2.23$, $4.19{\pm}2.16$, $5.81{\pm}4.20$, $1.83{\pm}9.17$, respectively) in Positive Affect (PA) (F=3.931, p=0.024), PA-Joy (F=3.991, p=0.023), PA-Interest (F=5.025, p=0.009), NA-Afraid (F=3.118, p=0.050), and Difference between Positive and Negative Affect (DPN) (F=6.355, p=0.003) scores. The post-hoc analysis showed that the Tae-Eum type ($18.71{\pm}8.75$, $6.47{\pm}3.36$, $6.31{\pm}2.47$, $10.94{\pm}10.08$) has significantly higher score than So-Eum type ($13.38{\pm}6.03$, $4.55{\pm}2.23$, $4.19{\pm}2.16$, $1.83{\pm}9.17$, respectively) in PA (p=0.018), PA-Joy (p=0.021), PA-Interest (p=0.017), and DPN (p=0.002) scores. The So-Eum type ($5.81{\pm}4.20$) showed significantly (p=0.047) higher score than the Tae-Eum type ($3.18{\pm}2.77$) in NA-Afraid. Results demonstrated distinct affect profile differences between Tae-Eum and So-Eum Sasang types using PANAS. This study may serve as the foundation in identifying psychological traits of Sasang types, especially regarding the aspect of affect.

• Microbiology and Biotechnology Letters
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• v.23 no.5
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• pp.624-631
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• 1995

The fermentation characteristics of Saccharomyces cerevisiae F38-1, a newly isolated thermotolerant yeast strain from a high temperature environment have been studied using a fermentation medium containing 20% glucose, 0.2% yeast extract, 0.2% polypeptone, 0.3% (NH$_{4}$)$_{2}$SO$_{4}$, 0.1% KH$_{2}$PO$_{4}$, and 0.2% MgSO$_{4}$ without shaking at 30$\circ$C to 43$\circ$C for 5 days. The fermentability was over 90% at 30$\circ$C, 88% at 37$\circ$C, 77% at 40$\circ$C and 30% at 43$\circ$C. A similar fermentation result was obtained at pH between 4 and 6 at 30$\circ$C and 40$\circ$C. Aeration stimulated the growth of the strain at the beginning of the fermentation, but it reduced alcohol production at the end of alcohol fermentation. Optimal glucose concentration was determined to be between 18 and 22% at 40$\circ$C as well as 30$\circ$C, but the growth was inhibited at the glucose concentration of over 30%. A fermentability of over 90% was observed at 40$\circ$C in 2 days when the medium was supplemented by 2% yeast extract. A higher inoculum size increased the initial fermentation rate, but not the fermentation. A fermentability of over 90% was achieved in 2 days at 40$\circ$C in a fermentor experiment using an optimized medium containing 20% glucose and 1% yeast extract.