• Title/Summary/Keyword: $[^{18}F]F_2$

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Usefulness of F-18 FDG PET/CT in Staging of Peripheral T Cell Lymphoma (말초성 T 세포 림프종의 병기 설정시 F-18 FDG PET/CT의 유용성)

  • Kang, Yun-Hee;Lim, Seok-Tae;Kim, Dong-Wook;Jeong, Hwan-Jeong;Sohn, Myung-Hee;Yim, Chang-Yeol
    • Nuclear Medicine and Molecular Imaging
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    • v.42 no.5
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    • pp.369-374
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    • 2008
  • Purpose: F-18 FDG PET/CT has excellent sensitivity and specificity for staging non-Hodgkin lymphomas, but to the author's knowledge few studies to date have evaluated FDG PET/CT in peripheral T cell lymphoma. We evaluated the usefulness of F-18 FDG PET/CT in staging of patients with peripheral T cell lymphoma, especially indolent cutaneous T cell lymphomas. Materials and Methods: Twenty five patients (M:F=17:8, age $53.7{\pm}14.8$ yrs) with biopsy-proven indolent cutaneous T cell (CL) or noncutaneous T cell lymphomas (NCL) underwent PET/CT scans for staging at baseline. Peak standardized uptake values (p-SUV) of all abnormal foci were measured and compared between cutaneous and noncutaneous lesions. F-18 FDG PET/CT was performed on 6 patients with indolent CL and on 19 patients with NCL. Results: All 6 patients with indolent CL had no significant FDG avidity in the skin despite histologically positive cutaneous lesions. However, FDG avidity appeared in extracutaneous lesions (lymph nodes) in two patients with CL where CT imaging suggested lymphoma involvement (mean p-SUV $4.26{\pm}0.37$ in noncutaneous lesions in CL). In NCL, FDG avidity was demonstrated in all lesions where CT imaging suggested lymphoma involvement (mean p-SUV, $8.52{\pm}5.00$ in noncutaneous lesions in NCL). Conclusion: F-18 FDG PET/CT has the limitation of usefulness for the evaluation of the skin in indolent CL. In contrast, F-18 FDG PET/CT is sensitive in staging evaluation of extracutaneous lesions regardless of CL or NCL.

Self Production of Radioisotope and Radiopharmaceuticals Divider (방사성동위원소 및 방사성의약품 분주장치의 자체제작)

  • Hong, Sung-Tack;Park, Kwang-Seo;Kim, Seok-Ki;Won, Woo-Jae
    • The Korean Journal of Nuclear Medicine Technology
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    • v.14 no.2
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    • pp.177-180
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    • 2010
  • Purpose: As PET test came to be covered by the pay system of medical insurance (July 1, 2006) and the needs for it becoming increased for laboratory purpose, it became necessary to purchase expensive medical equipments to solve those problems. However, as most of equipments that are operated by cyclotron are very expensive as to amount from tens of millions up to hundreds of millions of won, it is difficult to purchase those equipments from the point of medical organizations. It may be possible to self manufacture those equipments with least costs if their parts functions that meets the operators demands. The Nuclear Medicine department of National Cancer Center (NCC) is trying to manufacture and use equipments that can be made with least costs, including introducing 2 medical equipments that can improves the operator's works. Materials and Methods: Example 1: Self production of radioisotope($^{18}F$) divider was fabricated. The NCC's Nuclear Medicine department acquired one acrylic panel, seven 3-way valve, tubing etc. that can be found in the market to make the main body of divider in cooperation with biomedical engineering, and placed them inside hot cell, and installed switching box outside of hot cell to make it possible to control them from outside. This main body of divider were placed in radioisotope transfer line that are manufactured in the cyclotron. Example 2: Self production of $^{18}F$-FDG automated divider was fabricated. The NCC's Nuclear Medicine department used cavro pump syringe that consists the main body of divider in cooperation with biomedical engineering, biomedical engineering developed programs that divides a certain amount. $^{18}F$-FDG automated divider is placed inside hot cell, and cable chords were used in the equipment, and then it was connected to PC outside hot cell to make it possible to control the $^{18}F$-FDG automated divider. Results: From the NCC's Nuclear Medicine department tests that were carried out from March, 2007 until now, we found out that radioisotope can be sent to radiopharmaceuticals composite module we want, and from the tests that are carried out at NCC's Nuclear Medicine department using $^{18}F$-FDG automated divider since August, 2009 it was possible to distribute radiopharmaceuticals into vial intended. Conclusion: Through the two examples above, we found out that costs can be reduced by self manufacturing expensive equipments from NCC's cyclotron room with least costs. Also, it decreased radiation exposure dose on workers, and set up problem solving processes in cooperation with lots of parties related.

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A Study on the Performance of Solar Heat, Pump Cycle System for $CH_2F_2$, $CF_3CHF_2$ and $CF_3CH_2F$( I ) ($CH_2F_2-CF_3CH_2F-CF_3CHF_2$계 냉매적용 태양열 열펌프시스템 성능 연구( I ))

  • Lee, Soon-Bok;Jung, Hyun-Chai;Bae, Chun-Woo;Sun, Kyung-Ho
    • Journal of the Korean Solar Energy Society
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    • v.23 no.2
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    • pp.71-79
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    • 2003
  • The goal of this paper is to measure and compare the performance of solar heat pump for refrigerants. To accomplish the goal, solar heat pump with aluminum roll bond type evaporator and indoor heat exchanged(condenser) was built. The test results showed that the COP and heating capacity of HFC-32/125/134a(23/25/52 wt%, $CH_2F_2/CF_3CHF_2/CF_3CH_2F$) were higher than those of HCFC-22$(CHClF_2)$. A study proved that best conditions to use heating system that is about $40m^2$ and $80m^2$. The COP range of the whole system was from 4 to 6 according to the solar collector's area variation. Hydrochlo-rofluorocarbon HCFC-22$(CHClF_2)$ is included in the compound to be controlled. HFC-32/125/134a(23/25/52 wt%, $CH_2F_2/CF_3CHF_2/CF_3CH_2F$) is the most suitable replacement HCFC-22$(CHClF_2)$ in solar heat pump application. The solar heat pump system was designed to show the best efficiency that the room temperature make $18\sim20^{\circ}C$ and $23\sim25^{\circ}C$ in Seoul during the fall season.

Relationship between Body image and Depression of Diabetes Mellitus Patients (당뇨병환자의 신체상과 우울과의 관계)

  • Lee, Myung-Hwa;Song, Myung-Sook
    • The Korean Journal of Rehabilitation Nursing
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    • v.5 no.1
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    • pp.49-59
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    • 2002
  • The purpose of study was to identify relationship between body image and depression of diabetes mellitus patients. The subjects of study were 120 diabetes mellitus patients who were B hospital in Pusan. Data were collected from 15th April to 20th August, 1998. The instrument used for this study were Osgood's body image scale and Zung's depression scale. The collected data were analyzed frequency, percentage, mean, standard deviation, t-test, ANOVA, Scheffe test, Pearson's correlation coefficients. The results were as follows: 1. The mean score of body image was $68.91{\pm}18.04$, and the mean score of depression was $56.18{\pm}11.58$. 2. The score of body image according to marital status(t=-2.434, p=.016), economic status (F=6.252, p=.001), reason of different regular hospital visiting(F=3.017, p=.014), treatment method of diabetes mellitus(F=3.048, p=.013) were significantly difference. ere significantly difference. 3. The score of depression according to sex(t=2.353, p=.020), occupational status(F=4.657, p=.002), marital status(t=-2.325, p=.022), economic status(F=5.536, p=.001), regular hospital visiting(t=2.081, p=.040), reason of different regular hospital visiting(F=3.352, p=.007), treatment method of diabetes mellitus(F=3.102, p=.012), paticipation of diabetes mellitus(t=3.726, p=.000), paticipation of diabetes mellitus visiting(F=4.819, p=.003) were significantly difference. 5. Body image and depression was a significant negative correlation(r=-.679. p=.000). Conclusion: From this study, a relationship between body image and depression inpatients with diabetes mellitus was idetified. Therefore, nursing intervention are needed to promote body image and depression in patients with diabetes mellitus.

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An Improved Active Damping Method with Capacitor Current Feedback

  • Geng, Yi-Wen;Qi, Ya-Wen;Liu, Hai-Wei;Guo, Fei;Zheng, Peng-Fei;Li, Yong-Gang;Dong, Wen-Ming
    • Journal of Power Electronics
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    • v.18 no.2
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    • pp.511-521
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    • 2018
  • Proportional capacitor current feedback active damping (CCFAD) has a limited valid damping region in the discrete time domain as (0, $f_s/6$. However, the resonance frequency ($f_r$) of an LCL-type filter is usually designed to be less than half the sampling frequency ($f_s$) with the symmetry regular sampling method. Therefore, ($f_s/6$, $f_s/2$) becomes an invalid damping region. This paper proposes an improved CCFAD method to extend the valid damping region from (0, $f_s/6$ to (0, $f_s/2$), which covers all of the possible resonance frequencies in the design procedure. The full-valid damping region is obtained and the stability margin of the system is analyzed in the discrete time domain with the Nyquist criterion. Results show that the system can operate stably with the proposed CCFAD method when the resonance frequency is in the region (0, $f_s/2$). The performances at the steady and dynamic state are enhanced by the selected feedback coefficient H and controller gain $K_p$. Finally, the feasibility and effectiveness of the proposed CCFAD method are verified by simulation and experimental results.

Development of a 2.14-GHz High Efficiency Class-F Power Amplifier (2.14-GHz 대역 고효율 Class-F 전력 증폭기 개발)

  • Kim, Jung-Joon;Moon, Jung-Hwan;Kim, Jang-Heon;Kim, Il-Du;Jun, Myoung-Su;Kim, Bum-Man
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.18 no.8
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    • pp.873-879
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    • 2007
  • We have implemented a highly efficient 2.14-GHz class-F amplifier using Freescale 4-W peak envelope power(PEP) RF Si lateral diffusion metal-oxide-semiconductor field effect transistor(LDMOSFET). Because the control of the all harmonic contents is very difficult, we have managed only the $2^{nd}\;and\;3^{rd}$ harmonics to obtain the high efficiency with simple harmonic control circuit. In order to design the harmonic control circuit accurately, we extracted the bonding wire inductance and drain-source capacitance which are dominant parasitic and package effect components of the device. And then, we have fabricated the class-F amplifier. The measured drain and power-added efficiency are 65.1 % and 60,3 %, respectively.

Natural Convection Heat Transfer from a Conducting Tube with Two Vertical Axial Fins (2개(個)의 수직(垂直) 평판(平板)핀을 가진 전도관(傳導管)으로 부터의 자연대류(自然對流) 열전달(熱傳達))

  • Chung, H.S.;Lee, C.J.;Kwon, S.S.
    • Korean Journal of Air-Conditioning and Refrigeration Engineering
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    • v.3 no.4
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    • pp.222-230
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    • 1991
  • Conjugate heat transfer by steady laminar natural convection from a conducting tube with two vertical axial fins has been studied by a finite difference numerical procedure under basic conditions; $Ra=10_6$, Pr = 5 and $L_F=0.15$. The maximum local tube Nusselt number appears at ${\theta}=140^{\circ}$ for $L_F=0.06$, at ${\theta}=130^{\circ}$ for $L_F=0.30$ and at ${\theta}=120^{\circ}$ for $L_F=0.30$, $L_F=0.06$, respectively. The maximum mean Nusselt number shows at $L_F=0.18$ for the downward fin and at $L_F=0.12$ for the upward fin. Therefore the optimized fin length is $L_F{\approx}0.15$ under these conditions. At $L_F=0.15$, the mean Nusselt number by increasing Rayleigh number is remarkably increased for downward fin and then is slowly increased except for downward fin, it by increasing Prandtl number is apparently increased at $Pr{\leq}2$, and slightly increased at Pr>2.

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Studies on Heterosis Breeding in Rapeseed Using Cytoplasmic Male Sterility 2, Agronomic Characteristics of F_1 Seed Production Procedure in the Three-way Crossing of Cytoplasmic-genetic Male Sterile, Non-Isogenic Maintainer and Restorer on Rape (Brassica napus L.) (세포질 유전자적 웅성불임계통을 이용한 유체 Heterosis 육종 개발에 관한 연구 제2보 웅성불임계통에 Non-Isogenic Maintainer를 활용한 유체 3원교잡F_1의 형질발현과 F_1종자생육)

  • Jung-Il Lee;Jung-Il Lee
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.25 no.2
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    • pp.49-57
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    • 1980
  • A $F_1$ hybrid out of 143 crosses of rape (Brassica napus) using cytoplasmic-genetic male sterility yielded 5.18 tons per hectare. European and native varieties used, were found out to have 78% and 58% of genes restoring fertility, respectively. The $F_1$ hybrids of three way cross using non-isogenic maintainer showed higher heteroses than those of double cross. To produce F 1 hybrids of three way cross, three stages of crossing operations are needed and seeds produced from about 60 hectares can be covered to 60, 000 hectares.

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Reduction of Injection Dose in 18F-FDG Fusion PET (PET-CT 검사에서 18F-FDG 투여량 감소에 대한 고찰)

  • Kim, Jong-Pil;Kim, Jae-Il;Lee, Hong-Jae;Kim, Jin-Eui
    • The Korean Journal of Nuclear Medicine Technology
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    • v.18 no.2
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    • pp.17-21
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    • 2014
  • Purpose With the recent rise of social issue regarding radiation exposure, attention to medical radiation use has been placed under a great spotlight. During PET-CT examination, generally about 40% more of $^{18}F$-FDG is used than EANM recommendation. While maintaining the diagnostic test result, we hope to find optimal injection dose to minimize the $^{18}F$-FDG in patients by utilizing the latest PET-CT scanner which is equiped with the newest technology. Materials and Methods During this experiment, the Biograph Truepoint 40 (siemens, USA) installed in 2007 and mCT 64 (siemens, USA) installed in 2011 were used and evaluated NECR (noise-equivalent counting rate) by using a scatter phantom. For the image quality evaluation of each scanner, we injected 3.7, 4.44 and 5.18 MBq/kg of $^{18}F$-FDG in NEMA IEC Body Phantom and also evaluated SNR between two scanners by using the data acquired at 60, 70, 80, 90, 100, 110 and 120 sec per bed. For the clinical evaluation, actual data of patients who were injected $^{18}F$-FDG 3.7, 4.44, 5.18 MBq/kg were used to compare SNR and draw a final result. Results As a result, mCT 64 peak NECR value was 1.65e+005, which is 10% higher than Turepoint 40. SNR values using the IEC body phantom was 17.9%, 17.4% and 17.1% higher in $^{18}F$-FDG 3.7 MBq/kg, 4.44 MBq/kg and 5.18 MBq/kg. In clinical patients, SNR values of the image mCT 64 was 16.5, which is 25% higher than Turepoint 40 scanner. Conclusion To draw a conclusion from the test result of this experiment, the same quality of SNR could be attained even with 10% reduced injection dose, if when the duration is extended by 10 sec/bed. This optimal result was possible due to enhanced equipment. The NECR (one of the equipment's performance assessment criteria for the scanner) increased by 10% and the SNR (one of the image quality assessment criteria) also increased by 17.5%. Therefore, we can expect to reduce the injection dose without deterioration of image quality. In consequence, it will also help to decrease the patient's anxiety of the radiation exposure.

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호스피스 자원봉사자 교육이 죽음에 대한 성향에 미치는 효과

  • Ju, Ri-Ae
    • Korean Journal of Hospice Care
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    • v.5 no.2
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    • pp.1-14
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    • 2005
  • The purpose of this study was to promote the popularization of hospice services by providing the information about the influences of hospice training on participants. We compared differences of attitudes toward death between those of pre-training and post-training by use of questionnaire. This study involved 137 volunteers participating in the hospice training held by one hospice center located in K-city. The questionnaire was composed of 46 items, 21 items of general information and 25 items of information about attitudes toward death. We applied Park's translated version(1992), originally distributed by Thorson and Powell(1988), in the assessment of participants' changed attitudes toward death. Participants were asked to fill out the questionnaire before and after the hospice training. The data were analged by frequency. ANOVA t-test, paired t-test. The results were as follows, 1.Pre-training items holding a high rank were 'The subject about the future life after death is distressing'(F=5.20), 'No worry about any occurrences around the body after a funeral'(F=4.75), 'Having little interest in being laid in a coffin after death'(F=4.56); items holding a low rank were 'Having little interest in any occurrences around the body after death'(F=2.22), 'Willing to deal with the aftermath of the death in detail'(F=1.94), 'No fear to have an idea to be cancerous'(F=1.72). 2.Post-training items holding a high rank were 'No fear to be dead as a result of sufferings from long-lasting illness'(F=3.18), 'No fear to have an idea to be cancerous'(F=3.16)', Having little interest in the future life after death'(F=3.09); items holding a low rank were 'Unpleasant to be not able to move after death(F=1.74), 'Distressing not to know about the future life after death'(F=1.61), 'The subject about the future life after death is distressing'(F=1.60). 3.There were significant difference in participants' attitudes toward death. Compared with pretraining(F=3.97), more positive were developed in post training(F=2.30). The results of this study indicate that hospice training renders positive regards toward death to the participants. Therefore every human being, who is able to speculate about the meaning of death, has to be exposed to the hospice training. In conclusion, hospice training should be popularized in the near future.

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