• BMB Reports
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• 제49권8호
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• pp.401-402
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• 2016

S6K1 is a key regulator of cell growth, cell size, and metabolism. Although the role of cytosolic S6K1 in cellular processes is well established, the function of S6K1 in the nucleus remains poorly understood. Our recent study has revealed that S6K1 is translocated into the nucleus upon adipogenic stimulus where it directly binds to and phosphorylates H2B at serine 36. Such phosphorylation promotes EZH2 recruitment and subsequent histone H3K27 trimethylation on the promoter of its target genes including Wnt6, Wnt10a, and Wnt10b, leading to repression of their expression. S6K1-mediated suppression of Wnt genes facilitates adipogenic differentiation through the expression of adipogenic transcription factors PPARγ and Cebpa. White adipose tissues from S6K1-deficient mice consistently exhibit marked reduction in H2BS36 phosphorylation (H2BS36p) and H3K27 trimethylation (H3K27me3), leading to enhanced expression of Wnt genes. In addition, expression levels of H2BS36p and H3K27me3 are highly elevated in white adipose tissues from mice fed on high-fat diet or from obese humans. These findings describe a novel role of S6K1 as a transcriptional regulator controlling an epigenetic network initiated by phosphorylation of H2B and trimethylation of H3, thus shutting off Wnt gene expression in early adipogenesis.

• 한국추진공학회지
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• 제16권6호
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• pp.85-91
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• 2012

본 논문은 우발적 화재에 노출된 고체 추진기관의 화재 위협이나 폭발을 파이로 센서가 자동적으로 감지하여 추진기관이 안전하게 연소되게 하는 둔감 점화 장치의 반응을 연구한 결과다. 완속 가열 시험은 HTPB 추진제가 충전된 로켓 모터에 열감지형 점화기를 장착하여 MIL-STD-2105D 규정에 따라 수행하였다. 얻어진 점화 온도는 약 $140^{\circ}C$였으며, 이는 "연소 반응" 등급에 해당되었다. Kissinger 식으로 구한 둔감 점화 장치 신호 화약의 자동 점화 온도는 $165.5^{\circ}C$였다.

• 한국가구학회지
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• 제29권1호
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• pp.8-17
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• 2018

Economic crisis in 2008 has changed South Korean market including furniture related field. Owing to Subprime Mortgage Crisis, new economic order, in other words, New Normal was established. Low growth rate, low interest, high unemployment rate, high risks, regulation strengthening, and all that sort of negative things have became generalized. South Korean economy has developed drastically since the Korean War, however recent economic crisis and Internet and smart phone have leading roles in shaping new consumption market. In a way, furniture market has expanded despite economic recession. Total service for housing is suited to South Korean consumers and shortened Product Life Cycle induces consumers to buy more furniture. In addition, Internet and smart phone allow people to show off their private spaces to unspecified masses. As a result, consumer prefers inexpensive and expendable furniture. It is certain that furniture market makes quantitative growth, but qualitative sides are questionable. Even though the study is focused on the existent circumstances, It will help to find out the proper ways of future furniture market in South Korea.

• 한국자동차공학회논문집
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• 제6권3호
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• pp.63-70
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• 1998

According to the stringent exhaust emission regulation control of air fuel ratio is one of the most important issues on gasoline engine. Although many researches have been carried out to identify the fuel transport phenomena in a port fueled gasoline engine, complexity of fuel film behavior in the intake port makes it difficult. The fuel film behavior was investigated recently by using visualization method and these gave us qualitative understanding. In this paper, the quantitative measurement method for the port fuel film is studied by using Fast Response Flame Ionization Detector(FRFID). The mass of fuel film on the port wall was measured by using the methods of fuel injection off, injection on and regression. The Fuel film mass was increased with incresing load at the same engine speed.

• 한국식물학회:학술대회논문집
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• 한국식물학회 1987년도 식물생명공학 심포지움 논문집 Proceedings of Symposia on Plant Biotechnology
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• pp.149-155
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• 1987

Growth and development of a higher plant, or any living organism for that matter, could be defined as an orderly expression of the genome in time and space in close interaction with the environment. During differentiation and development of a tissue or organ a group of genes must be selectively turned on or turned off mainly by trans-acting regulators. In this general concept of regulation of regulation of gene expression, a DNA molecule is recognized at a specific nucleotide sequence by DNA-binding factors. Molecular biology of the regulatory factors such as hormones, and their receptors, target DNA sequences and DNA-binding proteins are well advanced. What is not clearly understood is the molecular basis of the interactions between DNA and binding factors, expecially of the usages of the dyad symmetry of the target DNA sequences and the dimeric nature of the DNA-binding proteins. A unique 3-dimensional structure of DNA has been proposed that may play an important role in the orderly expression of the gene. A foldback intercoil (FBI) DNA configuration which was originally found by electron microscopy among mtDNA molecules from pearl millet has some unique features. The FBI configuration of DNA is believed to be formed when a flexible double helix folds back and interwines in the widened major grooves resulting in a four stranded, intercoil DNA whose thickness is the same as that of double stranded DNA. More recently, the FBI structure of DNA has been also induced in vitro by a novel enzyme which was purified from pearl millet mitochondria. It has been proposed that the FBI DNA could be utillized in intramolecular recombination which leads to inversion or deletion, and in intermolecular recombination which can lead to either site-specific recombination, genetic recombination via single strand invasion, or cross strand recombination. The structure and function of DNA in 3-dimensional aspect is emphasized for better understanding orderly expression of genes during growth and development.

• 대한통합의학회지
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• 제10권3호
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• pp.107-117
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• 2022

Purpose : The purpose of this study was to establish a model of the predictive factors for success or failure of examinees undertaking the Korean physical therapist licensing examination (KPTLE). Additionally, we assessed the pass/fail cut-off point. Methods : We analyzed the results of 10,881 examinees who undertook the KPTLE, using data provided by the Korea Health Personnel Licensing Examination Institute. The target variable was the test result (pass or fail), and the input variables were: sex, age, test subject, and total score. Frequency analysis, chi-square test, descriptive statistics, independent t-test, correlation analysis, binary logistic regression, and receiver operating characteristic (ROC) curve analyses were performed on the data. Results : Sex and age were not significant predictors of attaining a pass (p>.05). The test subjects with the highest probability of passing were, in order, medical regulation (MR) (Odds ratio (OR)=2.91, p<.001), foundations of physical therapy (FPT) (OR=2.86, p<.001), diagnosis and evaluation for physical therapy (DEPT) (OR=2.74, p<.001), physical therapy intervention (PTI) (OR=2.66, p<.001), and practical examination (PE) (OR=1.24, p<.001). The cut-off points for each subject were: FPT, 32.50; DEPT, 29.50; PTI, 44.50; MR, 14.50; and PE, 50.50. The total score (TS) was 164.50. The sensitivity, specificity, and the classification accuracy of the prediction model was 99 %, 98 %, and 99 %, respectively, indicating high accuracy. Area under the curve (AUC) values for each subject were: FPT, .958; DEPT, .968; PTI, .984; MR, .885; PE, .962; and TS, .998, indicating a high degree of fit. Conclusion : In our study, the predictive factors for passing KPTLE were identified, and the optimal cut-off point was calculated for each subject. Logistic regression was adequate to explain the predictive model. These results will provide universities and examinees with useful information for predicting their success or failure in the KPTLE.

• 한국원자력학회:학술대회논문집
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• 한국원자력학회 2004년도 추계학술발표회 발표논문집
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• pp.657-658
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• 2004

The reactor protection system (RPS) of HANARO is a safety class system. The reactor is tripped by dropping four shut off rods (SOR). The SOR system consists of a SOR, hydraulic pump, hydraulic cylinder, solenoid valves and a power supply unit which has the AC coil contactor as a switching component. The hydraulic pump lifts up the SOR. The SOR drops by loss of the hydraulic pressure in the hydraulic circuit at the occurrence of voltage sags or interruptions. From this experiment, we knew that the magnitude of the voltage sag which impacts on this system is 70V, 500msec. The reactor regulation system (RRS) of HANARO has four CARs which are connected to the driver through a magnetic clutch. The CAR drops by loss of electromagnetic force of the magnetic clutch when the deeper voltage sags to lower than 10V, 500msec.

• 전자공학회논문지A
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• 제33A권6호
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• pp.72-80
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• 1996

This paper presetns the development of a SSPA operating at KU-band(14~14.5 GHz) in order of replace TWTA used in the terrestria transponder of a satellite communication. The driving stage of SSPA uses internally matched 2W, 4W, 8W FET and the power stage is coupled with two internally matched 8W FET by branch-line cominer. The SSPA is fabricated with oth the RF circuit and the bias circuitry operating temperature compensation, regulation and sequence on aluminum housing. The SSPA testing resutls implemented in this way show 24.8$\pm$1dB small-signal gain, 41dBm P1dB power, a typical two tone C/IM3, -33dBc with single carrier backed off 6dB from p1dB, and gain stability over temeprature (-30~50)$\pm$1dB.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1997년도 추계학술대회 논문집 학회본부
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• pp.426-428
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• 1997

This paper presents the linearized optimal PWM techniques for current source GTO converter. This proposed method is to linearize an optimal PWM modulation strategy so that the turn-on/off-periods of the GTO switches can be computed on-line in real-time for any modulation index. This allows the rapid and continuous regulation of the DC output current while producing the sinusoidal AC input current waveform and unit power factor.

• Journal of Power Electronics
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• 제11권3호
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• pp.375-380
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• 2011

A STATic synchronous COMpensator (STATCOM) is a shunt connected voltage source converter (VSC) based FACTS controller using Gate Turn Off (GTO) power semiconductor devices employed for reactive power control. The operation principal is similar to that of a synchronous condenser. A typical application of a STATCOM is voltage regulation at the midpoint of a long transmission line for the enhancement of power transfer capability and/or reactive power control at the load centre. This paper presents the modeling of STATCOM with twenty four pulse three level VSC and Type-1 controller to regulate the reactive current or the bus voltage. The performance is evaluated by transient simulation. It is observed that, the STATCOM shows excellent transient response to step change in the reactive current reference. While the eigenvalue analysis is based on D-Q model, the transient simulation is based on both D-Q and 3 phase models of STATCOM (which considers switching action of VSC).