Pressure nanosensors are widely used in industry today. Cheap price, simple measurement circuit, and low energy consumption are the reasons for the widespread use of these sensors. The structure of these systems includes membranes, Wheatstone bridge circuits for measurement, and piezoresistor elements for use as the resistance, respectively. The development of intelligent artificial hands relies heavily on nano-sensor technology to provide precise sensory feedback and enhance user control. However, existing nano-sensors often face limitations in sensitivity, durability, and seamless integration with neural control systems, creating a gap in achieving lifelike prosthetic functionality. This study aims to creatively adjust both the underlying attributes (material composition, sensor architecture, signal processing) and the actual attributes (durability, real-world performance, compatibility) of nano-sensors to improve their efficiency in intelligent prosthetics significantly. The novelty lies in combining advanced nano-materials, structural optimization, and Artificial Intelligence (AI)-driven signal processing for multi-sensor fusion, an approach not fully explored in previous research. The study identifies key sensor limitations and enhances performance through graphene-based materials, structural redesign, and AI-driven signal optimization. Simulations and performance modeling assess expected gains in response time, sensitivity, and integration efficiency for next-generation artificial hands. Experimental and simulation results demonstrate a gauge factor improvement to 11.94, representing a 73.8 % increase over Carbon Nano Tube (CNT)-only films, with linearity maintained at Coefficient of Determination (R2) = 0.996. Electrical noise was reduced by 34 %, conductivity improved from 2.31×105 S/m to 2.78×105 S/m, and response latency decreased from 14.2 ms to 8.6 ms. Durability testing confirmed <3 % drift after 106 bending cycles and a 77.9 % lower degradation rate compared to Indium Tin Oxide (ITO) sensors, while control system integration expanded bandwidth by 74.5 % and improved error convergence by 31.6 %. Operational gains included a 54.4 % reduction in calibration time, a 127.2 % increase in data throughput, and a 43.3 % longer operational lifetime under continuous monitoring. These results confirm that the proposed Graphene-Carbon Nano Tube (G-CNT) sensor architecture, coupled with AI-based signal optimization, delivers a quantitatively superior solution for high-performance, long-life, and integration-ready tactile sensing in next-generation intelligent prosthetic systems.