This study was to investigate the relationship between nurses' self-leadership, empowerment, and patient-centered care and to identify the factors affecting nurses' patient-centered care. Data was collected from 146 nurses at D metropolitan general hospital through a questionnaire from May 2, 2023 to May 20, 2023. The analysis of the data consisted of descriptive statistics, t-test, ANOVA, Pearson's correlation coefficient, and multiple regression analysis. The results showed that self-leadership appeared a significant positive correlation between empowerment (r=.59, p<.001), patient-centered care (r=.61, p<.001), and empowerment showed a significant positive correlation between patient-centered care (r=.64 p<.001). In addition, the factors influencing the patient-centered care of the subjects were empowerment (β=0.42, p<.001), and self-leadership (β=0.34, p<.001), and the explanatory power of these variables was 47.2%. Therefore, in order to promote patient-centered care for nurses, it is necessary to develop various programs that can promote self-leadership and empowerment suitable for hospitals and to make active use of them.