Background: Acne vulgaris is a chronic inflammatory disorder of the pilosebaceous unit. In traditional medicine, the face is divided into regions corresponding to internal organs (Heart, Lung, Spleen, Liver, and Kidney) based on the principle that internal dysfunction is reflected externally. However, few studies have compared these traditional interpretations with the modern understanding of regional acne pathophysiology. Methods: A comprehensive literature review was conducted using PubMed, CNKI, RISS, and KCI databases to identify studies published between January 2000 and September 2025. Articles addressing regional facial acne distribution or organ correspondence in traditional medicine were included, while studies on acne caused by external, occupational, or frictional factors were excluded. Results: Eight traditional medicine and several Western medicine studies were analyzed. Traditional literature interpreted acne according to organ-based pathogenesis, whereas Western studies emphasized sebaceous activity, hormonal imbalance, and inflammatory mechanisms. Integrating both perspectives, facial acne was classified into three clinical zones: the upper zone (forehead and upper cheeks), corresponding to the Heart-Lung system, showed erythematous papules or comedones associated with stress and insomnia; the middle zone (nose, perioral area, and central cheeks), corresponding to the Spleen-Stomach system, showed pustular or seborrheic lesions related to dietary factors and gut-skin imbalance; and the lower zone (chin, jawline, and lower cheeks), corresponding to the Liver-Kidney system, showed deep nodular or cystic acne linked to hormonal fluctuations and emotional stress. Conclusions: This study compared traditional organ-based theories with modern pathophysiological mechanisms of facial acne and proposed an integrative three-zone classification (upper, middle, and lower). These findings revealed partial convergence between traditional and Western perspectives, suggesting that this approach may facilitate more individualized and integrative strategies for acne management.