Autonomous vehicles use sensors like LiDAR, radar, cameras, and ultrasonic sensors to collect real-time environmental data. Efficient cleaning methods for these sensors are essential to counter performance degradation from contaminants like snow, dust, sand, and mud. This study examined the impact of washer pressure, spray duration, spray angle, and target point on optimizing LiDAR sensor cleaning. Experimental design data revealed that washer pressure and spray duration are key factors. Due to physical limits and spray pump costs, increasing washer pressure infinitely is impractical. Optimal spray pressure was determined to be 7-8 bar. Spray duration affects water usage, so longer times mean higher consumption, necessitating consideration of the washer's tank capacity. The study suggests repeated short-duration sprays. The best cleaning efficiency occurred with a target point about 10 mm away and a spray angle of 20-30°. Using the central composite design of response surface methodology minimized experiments and helped select optimization factors.