Purpose: The aim of this study was to investigate the effects of respiratory exercise with gamification on the respiratory function, vital signs, mechanical muscle properties, exercise satisfaction, exercise adherence, and exercise commitment of university student smokers. Methods: Thirty-two university student smokers were divided into two groups: smokers with gamification (SG; n=17) and smokers without (no) gamification (SNG; n=15). Respiratory exercises involving balloon blowing were applied to both the SG and SNG groups, and gamification was applied only to the SG group. The respiratory exercise program was conducted 3 times a week for 2 weeks. Respiratory function, vital signs, and mechanical muscle properties (muscle frequency, stiffness, and decrement) were measured before and after the intervention. Exercise satisfaction, adherence, and commitment were measured only after the intervention. Results: The values of forced vital capacity increased in both the SG and SNG groups but were not significant (p > 0.05). The change in balloon size increased significantly only in the SG group (p < 0.05). Moreover, in the SG group, muscle frequency, stiffness, and decrement in the rectus abdominis and external oblique abdominis increased. Exercise satisfaction, adherence, and commitment were higher in the SG group than in the SNG group, but not significantly (p > 0.05). Conclusion: In conclusion, respiratory exercise with gamification increased exercise satisfaction, adherence, and commitment among university student smokers. In this regard, it would have improved respiratory function, vital signs, and mechanical muscle properties. Therefore, we suggest that respiratory exercises with gamification could be a useful intervention for treating patients.