권호 표지

Tuberculosis and Respiratory Diseases

대한결핵및호흡기학회 (The Korean Academy of Tuberculosis and Respiratory Diseases)

  • 계간
  • /
  • 1738-3536(pISSN)
  • /
  • 2005-6184(eISSN)

과학기술표준분류

  • 보건의료 ＞ 임상의학

Aim & Scope

Tuberculosis and Respiratory Diseases (Tuberc Respir Dis) is the official journal of the Korean Academy of Tuberculosis and Respiratory Diseases. The journal publishes high-quality, peer-reviewed clinical or research articles that contribute to the understanding of the pathophysiology, diagnosis, and treatment of tuberculosis and other respiratory diseases. The aims of the journal are to publish important articles, encourage the exchange of information between members and related healthcare providers, and improve patient and public health. The journal is distributed to members, related agencies, libraries and the International Union Against Tuberculosis and Lung Disease member countries. Manuscripts that fall outside the scope of the journal may be submitted for evaluation by the editorial board. Article types published are Original Article, Review, Image of the Month, Editorial and Letter to the Editor. The journal is published quarterly (January, April, July, and October). TRD is indexed/tracked/covered by Emerging Sources Citation Index (ESCI), KoreaMed, Synapse, KoMCI, PubMed, PubMed Central, CrossRef, SCOPUS, EMBASE, CAS, Google Scholar.

KSCI KCI SCOPUS

제77권5호

  1. Yoon, Yong Pill;Ryu, Jiho;Park, Su Hyun;Lee, Hyun Jae;Lee, Seungho;Lee, Sang Kook;Kim, Ju-Ock;Hong, Jang-Hee;Seok, Jeong Ho;Lee, Choong Jae 203
    https://doi.org/10.4046/trd.2014.77.5.203 PDF KSCI
    Background: In this study, we investigated whether lobetyolin, lobetyol, and methyl linoleate derived from Codonopsis pilosula affect MUC5AC mucin secretion, production, and gene expression from airway epithelial cells. Methods: Confluent NCI-H292 cells were pretreated with lobetyolin, lobetyol, or methyl linoleate for 30 minutes and then stimulated with phorbol 12-myristate 13-acetate (PMA) for 24 hours. The MUC5AC mucin gene expression, and mucin protein production and secretion were measured by reverse transcription polymerase chain reaction and enzyme-linked immunosorbent assay, respectively. Results: Lobetyolin, lobetyol, and methyl linoleate inhibited the gene expression of MUC5AC mucin induced by PMA; lobetyolin did not affect PMA-induced MUC5AC mucin production. However, lobetyol and methyl linoleate inhibited the production of MUC5AC mucin; lobetyolin and lobetyol did not significantly affect PMA-induced MUC5AC mucin secretion from NCI-H292 cells. However, methyl linoleate decreased the MUC5AC mucin secretion. Conclusion: These results suggest that among the three compounds, methyl linoleate can regulate gene expression, production, and secretion of MUC5AC mucin by directly acting on the airway epithelial cells.
  2. Kang, Hye Ran;Choi, Gyu-Sik;Park, Sun Jin;Song, Yoon Kyung;Kim, Jeong Min;Ha, Junghoon;Lee, Yung Hee;Lee, Byoung Hoon;Kim, Sang-Hoon;Lee, Jae Hyung 209
    https://doi.org/10.4046/trd.2014.77.5.209 PDF KSCI
    Background: Bronchiectasis and asthma are different in many respects, but some patients have both conditions. Studies assessing the effect of bronchiectasis on asthma exacerbation are rare. The aim of this study is to investigate the effect of bronchiectasis on asthma exacerbation. Methods: We enrolled 2,270 asthma patients who were followed up in our hospital. Fifty patients had bronchiectasis and asthma. We selected fifty age- and sex-matched controls from the 2,220 asthma patients without bronchiectasis, and assessed asthma exacerbation and its severity based on the annual incidence of total asthma exacerbation, annual prevalence of steroid use, and frequency of emergency room visits and hospitalizations due to asthma exacerbation in each group. Results: Fifty patients (2.2%) had bronchiectasis and asthma. The annual incidence of asthma exacerbation was higher in patients with asthma and bronchiectasis than in patients with asthma alone ($1.08{\pm}1.68$ vs. $0.35{\pm}0.42$, p=0.004). The annual prevalence of steroid use ($0.9{\pm}1.54$ vs. $0.26{\pm}0.36$, p=0.006) and the frequency of emergency room visits ($0.46{\pm}0.84$ vs. $0.02{\pm}0.13$, p=0.001) due to asthma exacerbation were also higher in patients with asthma and bronchiectasis than in patients with asthma alone. Conclusion: Bronchiectasis is associated with difficult asthma control.
  3. Han, Yang-Hee;Jung, Bock-Hyun;Kwon, Jun Sung;Lim, Jaemin 215
    https://doi.org/10.4046/trd.2014.77.5.215 PDF KSCI
    Tracheal invasion is an uncommon complication of thyroid cancer, but it can cause respiratory failure. A rigid bronchoscope may be used to help relieve airway obstruction, but general anesthesia is usually required. Tracheal balloon dilatation and stent insertion can be performed without general anesthesia, but complete airway obstruction during balloon inflation may be dangerous in some patients. Additionally, placement of the stent adjacent to the vocal cords can be technically challenging. An 86-year-old female patient with tracheal invasion resulting from thyroid cancer was admitted to our hospital because of worsening dyspnea. Due to the patient's refusal of general anesthesia and the interventional radiologist's difficulty in completing endotracheal stenting, we performed endotracheal tube balloon dilatation and argon plasma coagulation. We have successfully treated tracheal obstruction in the patient with thyroid cancer by using endotracheal tube balloon inflation and a flexible bronchoscope without general anesthesia or airway obstruction during balloon inflation.
  4. Choi, Joon Young;Cho, Sung Bae;Kim, Hyun Ho;Lee, In Hee;Lee, Hea Yon;Kang, Hye Seon;Lee, Hwa Young;Lee, Sook Young 219
    https://doi.org/10.4046/trd.2014.77.5.219 PDF KSCI
    Pneumatosis intestinalis (PI) is a very rare condition that is defined as the presence of gas within the subserosal or submucosal layer of the bowel. PI has been described in association with a variety of conditions including gastrointestinal tract disorders, pulmonary diseases, connective tissue disorders, organ transplantation, leukemia, and various immunodeficiency states. We report a rare case of a 74-year-old woman who complained of dyspnea during the management of acute asthma exacerbation and developed PI; but, it improved without any treatment.
  5. Cho, Byung Ha;Oh, Youngmin;Kang, Eun Seok;Hong, Yong Joo;Jeong, Hye Won;Lee, Ok-Jun;Chang, You-Jin;Choe, Kang Hyeon;Lee, Ki Man;An, Jin-Young 223
    https://doi.org/10.4046/trd.2014.77.5.223 PDF KSCI
    Aspergillus tracheobronchitis is a form of invasive pulmonary aspergillosis in which the Aspergillus infection is limited predominantly to the tracheobronchial tree. It occurs primarily in severely immunocompromised patients such as lung transplant recipients. Here, we report a case of Aspergillus tracheobronchitis in a 42-year-old man with diabetes mellitus, who presented with intractable cough, lack of expectoration of sputum, and chest discomfort. The patient did not respond to conventional treatment with antibiotics and antitussive agents, and he underwent bronchoscopy that showed multiple, discrete, gelatinous whitish plaques mainly involving the trachea and the left bronchus. On the basis of the bronchoscopic and microbiologic findings, we made the diagnosis of Aspergillus tracheobronchitis and initiated antifungal therapy. He showed gradual improvement in his symptoms and continued taking oral itraconazole for 6 months. Physicians should consider Aspergillus tracheobronchitis as a probable diagnosis in immunocompromised patients presenting with atypical respiratory symptoms and should try to establish a prompt diagnosis.
  6. Lee, Jung Yeon;Chon, Gyu Rak;Jung, Tae-Young;Sung, Heungsup;Shim, Tae Sun;Jo, Kyung-Wook 227
    https://doi.org/10.4046/trd.2014.77.5.227 PDF KSCI
    Segniliparus species is a novel genus that is reported to be the new emerging respiratory pathogens. Here, we report a very rare case of S. rugosus pulmonary infection in an immunocompetent patient with non-cystic fibrosis. The organism was identified by 16S rRNA gene sequencing. The patient was successfully treated with antibiotics.