권호 표지

Tuberculosis and Respiratory Diseases

대한결핵및호흡기학회 (The Korean Academy of Tuberculosis and Respiratory Diseases)

  • 계간
  • /
  • 1738-3536(pISSN)
  • /
  • 2005-6184(eISSN)

과학기술표준분류

  • 보건의료 ＞ 임상의학

Aim & Scope

Tuberculosis and Respiratory Diseases (Tuberc Respir Dis) is the official journal of the Korean Academy of Tuberculosis and Respiratory Diseases. The journal publishes high-quality, peer-reviewed clinical or research articles that contribute to the understanding of the pathophysiology, diagnosis, and treatment of tuberculosis and other respiratory diseases. The aims of the journal are to publish important articles, encourage the exchange of information between members and related healthcare providers, and improve patient and public health. The journal is distributed to members, related agencies, libraries and the International Union Against Tuberculosis and Lung Disease member countries. Manuscripts that fall outside the scope of the journal may be submitted for evaluation by the editorial board. Article types published are Original Article, Review, Image of the Month, Editorial and Letter to the Editor. The journal is published quarterly (January, April, July, and October). TRD is indexed/tracked/covered by Emerging Sources Citation Index (ESCI), KoreaMed, Synapse, KoMCI, PubMed, PubMed Central, CrossRef, SCOPUS, EMBASE, CAS, Google Scholar.

KSCI KCI SCOPUS

제75권5호

  1. Jung, Chi Young 181
    https://doi.org/10.4046/trd.2013.75.5.181 PDF KSCI
    The emergence of new therapeutic agents for non-small cell lung cancer (NSCLC) implies that histologic subtyping and molecular predictive testing are now essential for therapeutic decisions. Histologic subtype predicts the efficacy and toxicity of some treatment agents, as do genetic alterations, which can be important predictive factors in treatment selection. Molecular markers, such as epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase (ALK) rearrangement, are the best predictors of response to specific tyrosine kinase inhibitor treatment agents. As the majority of patients with NSCLC present with unresectable disease, it is therefore crucial to optimize the use of tissue samples for diagnostic and predictive examinations, particularly for small biopsy and cytology specimens. Therefore, each institution needs to develop a diagnostic approach requiring close communication between the pulmonologist, radiologist, pathologist, and oncologist in order to preserve sufficient biopsy materials for molecular analysis as well as to ensure rapid diagnosis. Currently, personalized medicine in NSCLC is based on the histologic subtype and molecular status. This review summarizes strategies for tissue acquisition, histologic subtyping and molecular analysis for predictive testing in NSCLC.
  2. Yang, Sei-Hoon 188
    https://doi.org/10.4046/trd.2013.75.5.188 PDF KSCI
    Over the past decade, several kinase inhibitors have been approved based on their clinical benefit in cancer patients. Unfortunately, in many cases, patients develop resistance to these agents via secondary mutations and alternative mechanisms. To date, several major mechanisms of acquired resistance, such as secondary mutation of the epidermal growth factor receptor (EGFR) gene, amplification of the MET gene and overexpression of hepatocyte growth factor, have been reported. This review describes the recent findings on the mechanisms of primary and acquired resistance to EGFR tyrosine kinase inhibitors and acquired resistance to anaplastic lymphoma kinase inhibitors, primarily focusing on non-small cell lung carcinoma.
  3. Koh, Won-Jung;Chang, Boksoon;Jeong, Byeong-Ho;Jeon, Kyeongman;Kim, Su-Young;Lee, Nam Yong;Ki, Chang-Seok;Kwon, O Jung 199
    https://doi.org/10.4046/trd.2013.75.5.199 PDF KSCI
    Background: The number of patients with pulmonary disease caused by nontuberculous mycobacteria (NTM) has been increasing worldwide. The aim of this study was to evaluate long-term trends in the NTM recovery rate from respiratory specimens over a 10-year period in a tertiary referral hospital in South Korea. Methods: We retrospectively reviewed the records of mycobacterial cultures of respiratory specimens at Samsung Medical Center from January 2001 to December 2011. Results: During the study period, 32,841 respiratory specimens from 10,563 patients were found to be culture-positive for mycobacteria. These included 12,619 (38%) Mycobacterium tuberculosis and 20,222 (62%) NTM isolates. The proportion of NTM among all positive mycobacterial cultures increased from 43% (548/1,283) in 2001 to 70% (3,341/4,800) in 2011 (p<0.001, test for trend). The recovery rate of NTM isolates from acid-fast bacilli smear-positive specimens increased from 9% (38/417) in 2001 to 64% (1,284/1,997) in 2011 (p<0.001, test for trend). The proportion of positive liquid cultures was higher for NTM than for M. tuberculosis (p<0.001). The most frequently isolated NTM were Mycobacterium avium-intracellulare complex (53%) and Mycobacterium abscessus-massiliense complex (25%). Conclusion: The recovery rate of NTM from respiratory specimens in South Korea has increased steadily.
  4. Ryu, Jiho;Lee, Hyun Jae;Park, Su Hyun;Sikder, Md. Asaduzzaman;Kim, Ju-Ock;Hong, Jang-Hee;Seok, Jeong Ho;Lee, Choong Jae 205
    https://doi.org/10.4046/trd.2013.75.5.205 PDF KSCI
    Background: We investigated whether prunetin significantly affects tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$)-induced MUC5AC mucin gene expression, production, inhibitory kappa B ($I{\kappa}B$) degradation and nuclear factor kappa B (NF-kB) p65 translocation in human airway epithelial cells. Methods: Confluent NCI-H292 cells were pretreated with prunetin for 30 minutes and then stimulated with TNF-${\alpha}$ for 24 hours or the indicated periods. MUC5AC mucin gene expression and mucin protein production were measured by reverse transcription polymerase chain reaction and enzyme-linked immunosorbent assay, respectively. The effect of prunetin on TNF-${\alpha}$-induced degradation of $I{\kappa}B$ and translocation of NF-${\kappa}B$ p65 was investigated by western blot analysis. Results: We found that incubation of NCI-H292 cells with prunetin significantly inhibited mucin production and down-regulated the MUC5AC gene expression induced by TNF-${\alpha}$. Prunetin inhibited TNF-${\alpha}$-induced degradation of $I{\kappa}B$ and translocation of NF-${\kappa}B$ p65. Conclusion: This result suggests that prunetin inhibits the NF-${\kappa}B$ signaling pathway, which may explain its role in the inhibition of MUC5AC mucin gene expression and production regulated by the NF-${\kappa}B$ signaling pathway.
  5. Kim, Hyung Joon;Cho, Sun Young;Cho, Woo Hee;Lee, Do Hyun;Lim, Do Hyoung;Seo, Pil Won;Park, Mi-Hyun;Lee, Wonae;Lee, Jai Hyuen;Kim, Doh Hyung 210
    https://doi.org/10.4046/trd.2013.75.5.210 PDF KSCI
    Superior vena cava syndrome (SVCS) is usually caused by extrinsic compression or invasion of the superior vena cava (SVC) by malignant tumors involving mediastinal structures. Although thymomas are well-known causes of SVCS, cases of SVCS caused by malignant thymomas protruding into adjacent vessels draining the SVC with thrombosis have been very rarely reported worldwide. We experienced a 39-year-old female patient with SVCS that developed after the direct invasion of the left brachiocephalic vein (LBCV) and SVC by an anterior mediastinal mass with a high maximum standardized uptake value on the chest computed tomography (CT) and positron emission tomography-CT. Based on these results, she underwent en bloc resection of the tumor, including removal of the involved vessels, and was eventually diagnosed as having a type B2 thymoma permeating into the LBCV and SVC. We present this case as a very rare form of SVCS caused by an invasive thymoma.
  6. Hwang, Eu Dong;Kim, Young Jae;Leem, Ah Young;Ji, Ah-Young;Choi, Younjeong;Jung, Ji Ye;Kim, Se Kyu;Chang, Joon;Park, Ji Hye;Park, Seon Cheol 214
    https://doi.org/10.4046/trd.2013.75.5.214 PDF KSCI
    Treatment of lung cancer in patients with idiopathic pulmonary fibrosis (IPF) is difficult because the mortality rate after surgery or chemotherapy is high for these patients. Spontaneous regression of cancer is rare, especially in lung cancer. A 62-year-old man, previously diagnosed with IPF, presented with stage IIIC (T2N3M0) non-small cell lung cancer. About 4 months later, spontaneous regression of the primary tumor was observed without treatment. To the best of our knowledge, this is the first report of spontaneous regression of lung cancer in a patient with IPF.
  7. Yeo, Hye Ju;Lee, Soo Yong;Ahn, Eunyoung;Kim, Eun Jung;Rhu, Dae Gon;Choi, Kyoung Un;Lee, Seung Eun;Cho, Woo Hyun;Jeon, Doosoo;Kim, Yun Seong 218
    https://doi.org/10.4046/trd.2013.75.5.218 PDF KSCI
    This report describes a rare case of a patient with splenic tuberculosis (TB) who developed spontaneous splenic rupture after 10 weeks of antituberculous chemotherapy. The patient responded well to the antituberculous regimen prior to the spontaneous splenic rupture. We considered a paradoxical reaction as a cause of the splenic rupture. The patient underwent splenectomy and continuously received initial antituberculous drugs without change. To the best of our knowledge, this is the first report of spontaneous splenic rupture as a paradoxical reaction to antituberculous chemotherapy in an immunocompetent host with splenic TB.
  8. Park, Ju-Hee;Kim, Junghyun;Lee, Jung-Kyu;Kim, Soo Jung;Lee, Ae-Ra;Moon, Hyeon Jong;Kim, Deog Kyeom 222
    https://doi.org/10.4046/trd.2013.75.5.222 PDF KSCI
    Giant bullae are large bullae occupying at least one-third of the hemithorax and surgical bullectomy is the treatment of choice. We report a case with symptomatic giant bullae which were resected successfully. A 35-year-old man presented with bilateral giant bullae that occupied almost the entire left hemithorax and a third of the right hemithorax. He was a current smoker with a 30 pack-year history and he presented with dyspnea on exertion. An elective surgical bullectomy was performed with video-assisted thoracoscopic surgery. The patient recovered without any adverse events and stayed well for 1 month after surgery.