Let E be an elliptic curve defined over ℚ, and let p be an odd prime at which E has good ordinary reduction. Consider the p-primary Selmer group Selp∞(ℚ∞, E) over the cyclotomic ℤp-extension of ℚ, and denote its (algebraic) 𝜇-invariant by 𝜇p(E). Let ${\bar{\rho}}_{E,p}\;:\;Gal({\bar{\mathbb{Q}}}/{\mathbb{Q}}){\rightarrow}GL_2({\mathbb{Z}}/p{\mathbb{Z}})$ be the Galois representation arising from the action of the absolute Galois group on the p-torsion of E. Greenberg conjectured that if ${\bar{\rho}}_{E,p}$ is reducible, then there exists a rational isogeny E → E' of p-power degree such that 𝜇p(E') = 0. In this article, we investigate this conjecture by establishing sufficient Galois-theoretic criteria for its validity, formulated in terms of the representation ${\bar{\rho}}_{E,p}$. Our approach relies on a fundamental result of Coates and Sujatha concerning the fine Selmer group. Furthermore, in the case where ${\bar{\rho}}_{E,p}$ is irreducible, we show that our conditions imply 𝜇p(E) = 0 under the additional assumption that the classical Iwasawa 𝜇-invariant vanishes for the splitting field ${\mathbb{Q}}(E[p])={\bar{\mathbb{Q}}}^{ker\,{\bar{{\rho}}}_{E,p}}$.