대한방사선방어학회:학술대회논문집
대한방사선방어학회 (The Korean Association for Radiation Protection)
- 기타
과학기술표준분류
- 원자력 > 원자력 안전기술
- 원자력 > 핵연료주기/방사성폐기물 관리 기술
대한방사선방어학회 2011년도 추계 학술발표회 및 심포지엄
-
-
-
-
-
Huh, Hyun-Do;Choi, Sang-Hyoun;Kim, Woo-Chul;Kim, Hun-Jeong;Kim, Seong-Hoon;Ji, Young-Hoon;Kim, Kum-Bae;Shin, Dong-Oh;Lee, Suk;Shim, Jang-Bo;Cho, Sam-Ju;Lee, Sang-Hoon;Cho, Kwang-Hwan;Min, Chul-Kee 194
-
-
-
-
-
-
Kim, Sung-Jin;Jang, Seon-A;Yang, Kwang-Hee;Kim, Ji-Young;Kim, Cha-Soon;Nam, Seon-Young;Jeong, Mee-Seon;Jin, Young-Woo 212
The biological effects of low dose ionizing radiation (LDIR) remain insufficiently understood. We examined for the scientific evidence to show the biological effects of LDIR using radiation-sensitive immune cells. We found that Ikaros protein was responsed to low dose-dependent effects of gamma radiation in IM-9 B lymphocytes. Ikaros encodes zinc finger transcription factors that is important regulators of a hematopoietic stem cells (HSCs) progression to the B lymphoid lineage development, differentiation and proliferation. In this study, we observed that cell proliferation was enhanced from 10% to 20% by LDIR (0.05 Gy) in IM-9 B lymphocytes. The Ikaros protein was phosphorylated in its serine/threonine (S/T) region and decreased its DNA binding activity in the cells exposed to LDIR. We found that Ikaros phosphorylation was up-regulated by CK2/AKT pathway and the residues of ser-304 and ser-306 in Ikaros was phosphorylated by LDIR. We also observed that Ikaros protein was localized from the nucleus to the cytoplasm after LDIR and bound with Autotaxin (ENPP2, ATX) protein, stimulating proliferation, migration and survival of immune cells. In addition, we found that the lysoPLD activity of ATX was dependent on Ikaros-ATX binding activity. These results indicate that the Ikaros is an important regulator of immune activation. Therefore, we suggest that low dose ionizing radiation can be considered as a beneficial effects, stimulating the activation of immune cells. -
-
-
-
-
-
Kim, Jhin-Kee;Lee, Jeong-Ok;Kang, Jeong-Ku;Kim, Bu-Gil;Oh, Young-Kee;Jeong, Dong-Hyeok;Kim, Jeong-Kee 302
-
Kang, Young-Nam;Park, So-Hyun;Jeon, Dong-Min;Choi, Byeong-Oak;Jang, Hong-Seok;Kim, Yeon-Shil;Suh, Tae-Suk;Yoon, Sei-Chul 340
-
-
Jang, Hong-Seok;Jeon, Dong-Min;Park, So-Hyun;Kang, Young-Nam;Choi, Byeong-Oak;Kim, Yeon-Shil;Suh, Tae-Suk;Yoon, Sei-Chul 346
-