Archives of Obesity and Metabolism (비만대사연구학술지)

The Study of Obesity and Metabolic Syndrome, KAFM (대한가정의학회 비만대사증후군연구회)
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Factors Associated with Serum Testosterone Changes After Weight Loss in Young Males with Obesity

젊은 비만 남성에서 체중 감량 이후 혈청 테스토스테론 변화에 영향을 미치는 요인

  • Jun-Ho Lee (Department of Family Medicine, Konyang University Hospital, Konyang University College of Medicine) ;
  • Seunghyun Cheong (Department of Dermatology, Konyang University Hospital, Konyang University College of Medicine) ;
  • Jee-Hyun Kang (Department of Family Medicine, Konyang University Hospital, Konyang University College of Medicine)
  • 이준호 (건양대학교 의과대학 건양대학교병원 가정의학교실) ;
  • 정승현 (건양대학교 의과대학 건양대학교병원 피부학교실) ;
  • 강지현 (건양대학교 의과대학 건양대학교병원 가정의학교실)
  • Received : 2026.02.13
  • Accepted : 2026.06.05
  • Published : 2026.06.30
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Abstract

Background: This study aimed to investigate the factors associated with changes in serum testosterone levels following weight loss among young males with obesity. Methods: This retrospective observational study included 79 males aged 20-39 years selected from 465 patients with obesity who visited a hospital for weight reduction and underwent at least two serum testosterone measurements during follow-up. Pearson's correlation analysis evaluated associations between total serum testosterone levels and anthropometric and metabolic parameters. Multiple linear regression analysis identified independent factors associated with changes in total testosterone levels following weight loss. Results: The mean age of the participants was 30.3 ± 5.5 years, body weight was 102.0 ± 16.2 kg, waist circumference was 105.0 (99.0-114.5) cm, and body mass index was 32.9 ± 4.5 kg/m2. Following the weight-loss intervention, mean serum testosterone levels increased significantly (3.21 ± 1.34 ng/mL vs. 3.89 ± 1.45 ng/mL; P<0.001). Changes in total testosterone levels were inversely correlated with changes in body weight-related parameters, hemoglobin A1c levels, and triglyceride levels. Multiple linear regression analysis demonstrated that changes in waist circumference were independently associated with changes in serum testosterone levels (β = -0.609, P = 0.001). Conclusion: Reduced waist circumference was independently associated with increased serum testosterone levels. These findings suggest that reduction of abdominal obesity may be associated with improved serum testosterone levels.

Keywords

References

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