Journal of Dental Anesthesia and Pain Medicine

The Korean Dental Society of Anesthsiology (대한치과마취과학회)
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Efficacy of tenoxicam for postoperative dental pain: a systematic review of randomized controlled trials

  • Maryam Altuhafy (Department of Orofacial Pain and TMJ Disorders, Eastman Institute for Oral Health, University of Rochester) ;
  • Diya Kamdar (Department of Orofacial Pain and TMJ Disorders, Eastman Institute for Oral Health, University of Rochester) ;
  • Junad Khan (Department of Orofacial Pain and TMJ Disorders, Eastman Institute for Oral Health, University of Rochester)
  • Received : 2025.09.16
  • Accepted : 2026.01.18
  • Published : 2026.04.01
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Abstract

Postoperative pain commonly follows dental procedures, and appropriate analgesic selection plays a critical role in its management. This systematic review evaluated the efficacy and safety of tenoxicam compared with other pharmacological agents for postoperative dental pain control. Indexed databases, including PubMed, EMBASE, Ovid, Scopus, Web of Science, and the Cochrane Library, were searched through August 2025. Risk of bias was assessed using the Cochrane Risk of Bias tool for interventions. Nine randomized controlled trials met the inclusion criteria and covered a range of dental procedures, including third molar extraction, endodontic treatment, orthodontic adjustment, and implant surgery. Comparators included placebo, ibuprofen, diclofenac, flurbiprofen, meloxicam, methylprednisolone, and rofecoxib. Pain outcomes were measured primarily with the Visual Analogue Scale at multiple postoperative time points. Across studies, tenoxicam showed analgesic efficacy that was generally superior or comparable to other agents, with several trials reporting statistically significant reductions in pain scores at both early and later postoperative intervals. Most studies had low overall risk of bias, although some raised concerns related to allocation concealment and outcome reporting. Tenoxicam appears to be an effective and well-tolerated option for postoperative dental pain management. Study heterogeneity and domain-level bias concerns indicate a need for additional high-quality trials to confirm these findings and support routine clinical use.

Keywords

Acknowledgement

The authors acknowledge the Department of Orofacial Pain for the opportunity and support provided for conduct of this systematic review.

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