Clinical and Experimental Reproductive Medicine

The Korean Society for Reproductive Medicine (대한생식의학회)
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The impact of oxidation-reduction potential in follicular fluid on intracytoplasmic sperm injection outcomes

  • Minh Tam Le (Center for Reproductive Endocrinology and Infertility, Hue University of Medicine and Pharmacy, Hue University) ;
  • Thai Thanh Thi Nguyen (Center for Reproductive Endocrinology and Infertility, Hue University of Medicine and Pharmacy, Hue University) ;
  • Trung Van Nguyen (Center for Reproductive Endocrinology and Infertility, Hue University of Medicine and Pharmacy, Hue University) ;
  • Quoc Huy Vu Nguyen (Department of Obstetrics and Gynaecology, Hue University of Medicine and Pharmacy, Hue University)
  • Received : 2024.04.29
  • Accepted : 2024.09.17
  • Published : 2025.09.30
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Abstract

Objective: Follicular fluid (FF) oxidation-reduction potential (ORP) has shown promise as a predictor for in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) outcomes has been demonstrated. This study aimed to determine the association between the ORP in FF and IVF/ICSI outcomes. Methods: This cross-sectional study involved data collection from 341 couples undergoing IVF/ICSI treatment. The FF sample was taken from the first follicle to exceed 18 mm during oocyte retrieval and was analyzed for ORP using the MiOXSYS system (Caerus Biotechnologies). Results: ORP in FF exhibited a statistically significant negative correlation with the fertilization rate (correlation coefficient, -0.126; p=0.019). The ORP levels in the FF from the group with a lower fertilization rate (<80%) were significantly higher than those in the group with a higher fertilization rate (≥80%) (89.90 mV vs. 78.98 mV, p=0.030). No significant correlations were found between ORP in FF and other outcomes. Conclusion: Our findings suggested that the ORP in FF may be correlated with the fertilization rate and could be evaluated as a predictor of fertilization in ICSI.

Keywords

Acknowledgement

This work was supported by the Hue University project funding (grant number DHH2023-04-198) and the Core Research Program of Hue University under grant number NCM.DHH.2022.01 (Research Group on Reproductive Medicine).

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