동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)

  • 제39권4호
  • /
  • Pages.95-102
  • /
  • 2025
  • /
  • 1738-7698(pISSN)
  • /
  • 2288-2529(eISSN)
대한동의생리학회·한의병리학회 ( The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine)
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홍삼과 노루궁뎅이버섯 추출물이 Balb/c mice 비장세포의 활성에 미치는 영향

Effects of Red Ginseng and Hericium Erinaceus Extracts on the Activity of Balb/c Mouse Spleen Cells

  • 한충현 (대전대학교 한의과대학 침구의학과교실) ;
  • 이현 (대전대학교 한의과대학 침구의학과교실) ;
  • 강재희 (대전대학교 한의과대학 침구의학과교실) ;
  • 유화연 (대전대학교 한의과대학 침구의학과교실)
  • Choong Hyeon Han (Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Daejeon University) ;
  • Hyun Lee (Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Daejeon University) ;
  • Jae Hui Kang (Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Daejeon University) ;
  • Hwa Yeon Ryu (Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Daejeon University)
  • 투고 : 2025.05.08
  • 심사 : 2025.08.01
  • 발행 : 2025.08.25
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초록

The study aimed to evaluate the effects of mixed extracts of Hericium erinaceus and red ginseng on immune function activation. Splenocytes from Balb/c mice were used to assess the cytotoxicity and immune cell activity of Hericium erinaceus extract, Korean red ginseng extract, and their mixed extract (HRM). The concentrations of IL-2, IL-4, IL-12, and INF-γ were measured in various treatment groups. Hericium erinaceus extract showed cytotoxicity at high concentrations (HEE 400), with increased secretion of IL-2, IL-4, IL-12, and INF-γ in a concentration-dependent manner. Korean red ginseng extract and HRM also showed a concentration-dependent increase in these cytokines. Notably, IL-2, IL-4, and INF-γ were significantly higher in the RGE 400 and HRM 400 groups compared to the ConA group, and IL-12 was significantly higher in the RGE 400 group compared to the Normal and ConA groups. The study suggests that combined extracts of Koran Red ginseng and Hericium Erineceus may be more effective than single extracts in activating immune function, but further studies are needed to determine safety and human applicability.

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과제정보

본 연구는 2021년도 대전대학교 산학협력단의 지원에 의해 수행됨.

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