Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Studies on Anti-inflammatory Effects of Gyejigamcho-tang Extracts

계지감초탕(桂枝甘草湯) 추출물의 항염증(抗炎症)효과에 대한 연구

  • Tae Yeon Kim (College of Korean Medicine, Semyung University) ;
  • Na Young Jo (College of Korean Medicine, Semyung University)
  • 김태연 (세명대학교 한의과대학) ;
  • 조나영 (세명대학교 한의과대학)
  • Received : 2025.02.18
  • Accepted : 2025.04.21
  • Published : 2025.04.25
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Abstract

Gyejigamcho-tang (GG) is documented as a treatment for abnormal heart palpitations in Korean medicine. In this study, we investigated the anti-inflammatory effects of a water extract of GG on lipopolysaccharide (LPS)-induced RAW 264.7 cells. We first measured the levels of nitric oxide (NO) and prostaglandin E2 (PGE2), which are key products involved in inflammatory processes. Additionally, we assessed the levels of enzymes, such as inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), and cytokines, including interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α), and interleukin 1 beta (IL-1β). Our results showed that GG suppressed the production of NO and PGE2 in a dose-dependent manner and reduced both the protein levels and mRNA expression of iNOS and COX-2. Furthermore, GG decreased the mRNA expression of IL-6, TNF-α, and IL-1β. In conclusion, GG demonstrated the ability to reduce the production of LPS-induced inflammatory factors, suggesting its potential for clinical research into the treatment of inflammatory diseases.

Keywords

Acknowledgement

이 논문은 2022학년도 세명대학교 교내학술연구비 지원에 의해 수행된 연구임.

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