Clinical Endoscopy

  • 제58권2호
  • /
  • Pages.285-290
  • /
  • 2025
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  • 2234-2400(pISSN)
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  • 2234-2443(eISSN)
대한소화기내시경학회 (The Korean Society of Gastrointestinal Endoscopy)
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Bowel preparation for small bowel capsule endoscopy: standard regimen with 2 L polyethylene glycol versus 1 L polyethylene glycol plus ascorbate

  • Riccardo Caccia (Department of Pathophysiology and Transplantation, Universita degli Studi di Milano) ;
  • Alessandro Rimondi (Department of Pathophysiology and Transplantation, Universita degli Studi di Milano) ;
  • Luca Elli (Department of Pathophysiology and Transplantation, Universita degli Studi di Milano) ;
  • Matilde Topa (Department of Pathophysiology and Transplantation, Universita degli Studi di Milano) ;
  • Flaminia Cavallaro (Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico) ;
  • Carmine Gentile (Department of Pathophysiology and Transplantation, Universita degli Studi di Milano) ;
  • Lucia Scaramella (Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico) ;
  • Nicoletta Nandi (Department of Pathophysiology and Transplantation, Universita degli Studi di Milano) ;
  • Reena Sidhu (Academic Unit of Gastroenterology, Sheffield Teaching Hospitals) ;
  • Pinhas Eidler (Department of Pathophysiology and Transplantation, Universita degli Studi di Milano) ;
  • Maurizio Vecchi (Department of Pathophysiology and Transplantation, Universita degli Studi di Milano) ;
  • Gian Eugenio Tontini (Department of Pathophysiology and Transplantation, Universita degli Studi di Milano)
  • 투고 : 2024.04.22
  • 심사 : 2024.08.03
  • 발행 : 2025.03.30
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초록

Background/Aims: Optimization of bowel preparation for small bowel capsule endoscopy (SBCE) is debated. Guidelines recommend 2 L of iso-osmolar polyethylene glycol (PEG) to improve SBCE visibility. We compared the efficacy of the standard 2 L PEG solution with a 1 L PEG plus ascorbate (PEG-ASC) preparation, which has already been established for large-bowel preparation. Methods: Between October 2020 and February 2022, patients undergoing SBCE were assigned to receive 2 L PEG or 1 L PEG-ASC bowel preparation on an even- or odd-day basis. Bowel cleanliness was evaluated using the small bowel mucosal visibility scoring system (SBMVSS). Results: Following propensity score matching using a random forest method, two comparable populations of patients treated with 2 L PEG (n=74, male 41%, 53±17 years) and 1 L PEG-ASC (n=74, male 42%, 55±21 years) were obtained from the original cohort of 221 consecutive SBCE patients. Our results showed a trend towards more frequent adequate mucosal visibility with 1 L PEG-ASC compared to 2 L PEG (small bowel mucosal visibility ≥2 in all three small bowel tertiles, p=0.07), as per the SBMVSS score. No significant differences were observed in the diagnostic yield (p=1.00), visibility score=9 (p=0.85), SBCE completeness (p=0.33), or adequate mucosal visibility in each tertile (p=0.61, p=0.74, and p=0.70 for the first, second, and third tertiles, respectively). Conclusions: Our study suggests the non-inferiority of the 1 L PEG-ASC solution over the standard 2 L PEG for SBCE preparation.

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과제정보

This study was partially funded by Italian Ministry of Health-Current research IRCCS.

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