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  • Pages.7.1-7.15
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  • 2025
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  • 1598-2629(pISSN)
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  • 2092-6685(eISSN)
대한면역학회 (The Korean Association of Immunobiologists)
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Molecular Biology and Functions of T Follicular Helper Cells in Cancer and Immunotherapy

  • Mengyuan Xin (Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University) ;
  • Antuo Wang (Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University) ;
  • Minghao Ji (Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University) ;
  • Jingru Wu (Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University) ;
  • Bin Jiang (Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University) ;
  • Mo Shi (Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University) ;
  • Liang Song (Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University) ;
  • Zhongwei Xin (Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University)
  • 투고 : 2024.07.04
  • 심사 : 2025.01.08
  • 발행 : 2025.04.30
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⟨ 이전 논문 다음 논문 ⟩

초록

T follicular helper (Tfh) cells are integral to the germinal center (GC) response and the development of potent humoral immunity. By priming B cells, Tfh cells can initiate both extrafollicular and GC-dependent Ab responses. The dynamic physical interactions between Tfh and B cells constitute the primary platform for Tfh cells to provide essential "help" factors to B cells, as well as for reciprocal signaling from B cells to sustain the helper state of Tfh cells. In recent years, significant advancements have been made in understanding the diverse roles of Tfh cells across various diseases, particularly in cancer. Notably, beyond the classical GC-Tfh cells, it is increasingly recognized that the Tfh cell phenotype is highly heterogeneous and dynamic, which adds complexity to their roles in disease contexts. This review aims to encapsulate progress in Tfh cell biology, with a focus on their role in cancer and immunotherapy.

키워드

과제정보

We thank all the members of the Zhongwei Xin lab for discussions and comments on the manuscript. This work was supported by funding from the National Natural Science Foundation of China (82303183 to Zhongwei Xin) and the Natural Science Foundation of Shandong Province (ZR2023QH182 to Zhongwei Xin).

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