Journal of the Society of Cosmetic Scientists of Korea (대한화장품학회지)

Society of Cosmetic Scientists of Korea (대한화장품학회)
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Study on the Antioxidant Effects of Zanthoxylum piperitum Oil as a Cosmetic Ingredient

초피오일의 화장품 소재로서의 항산화 효능 연구

  • Byeong Bae Jeon (Suwon R&D Center, Hanbit Flavor & Fragrance) ;
  • Jung Un Shin (Research Institute for Biomedical and Health Science, Konkuk University) ;
  • Dong Wook Shin (Research Institute for Biomedical and Health Science, Konkuk University) ;
  • Dong-Ha Cho (Department of Bio-Health Convergence, Colleage of Biomedical Science, Kangwon National University)
  • 전병배 ((주)한빛향료) ;
  • 신정언 (건국대학교 의료생명대학 바이오융합과학부) ;
  • 신동욱 (건국대학교 의료생명대학 바이오융합과학부) ;
  • 조동하 (강원대학교 의생명과학대학 바이오헬스융합학과)
  • Received : 2025.02.07
  • Accepted : 2025.03.13
  • Published : 2025.03.30
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Abstract

Zanthoxylum piperitum oil (Z. piperitum oil) is a traditional Korean spice known for its anti-inflammatory and antioxidant properties, but its effects on human dermal fibroblasts (HDFs) have not been clearly elucidated. This study aimed to investigate the effects of Z. piperitum oil on oxidative stress, mitochondrial activity, and the regulation of MAPKs family signaling pathways in HDFs. Interestingly, we found that Z. piperitum oil significantly down-regulated the levels of reactive oxygen species (ROS) and recovered mitochondrial activity in tumor necrosis factor-alpha (TNF-α)-damaged HDFs. In addition, Z. piperitum oil inhibited the phosphorylation of MAPKs family proteins activated by TNF-α. Taken together, these findings suggest that Z. piperitum oil could potentially be used as an anti-aging ingredient by regulating oxidative stress and MAPKs family signaling pathways.

초피 오일(Zanthoxylum piperitum oil, Z. piperitum oil)은 항염증 및 항산화 특성으로 잘 알려진 전통적인 한국의 향신료이지만, 인간 진피 섬유아세포(human dermal fibroblasts, HDFs)에 미치는 영향은 명확히 밝혀지지 않았다. 본 연구에서는 Z. piperitum oil이 HDFs에서 산화 스트레스, 미토콘드리아 활성, 그리고 MAPKs family 신호 경로의 조절에 미치는 영향을 조사하고자 하였다. 흥미롭게도 Z. piperitum oil은 자극원인 tumor necrosis factor-alpha (TNF-α)로 손상된 HDFs에서 활성산소(ROS) 수치를 유의미하게 감소시키고 미토콘드리아 활성을 회복시켰다. 또한 Z. piperitum oil은 TNF-α에 의해 활성화된 MAPKs family 단백질의 인산화를 억제하는 것으로 나타났다. 결론적으로 Z. piperitum oil이 산화 스트레스와 MAPKs 패밀리 신호 경로를 조절함으로써 항노화 성분으로 활용될 수 있음을 시사한다.

Keywords

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