Journal of Korean Biological Nursing Science

Korean society of Biological Nursing Science (한국기초간호학회)
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Epidemiological characteristics of hospital-onset bloodstream infections and risk factors for peripheral venous catheter-associated bloodstream infections at a general hospital in South Korea: a retrospective case-control study

한국 일개 종합병원의 병원발생 혈류감염의 역학적 특성 및 말초정맥카테터 관련 혈류감염의 위험요인 분석: 후향적 사례-대조군 연구

  • Received : 2025.01.04
  • Accepted : 2025.02.05
  • Published : 2025.02.28
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Abstract

Purpose: This study investigated the incidence of hospital-onset bloodstream infections (HOBSI) and risk factors for HOBSI among patients with peripheral venous catheters (PVCs) at a general hospital. Methods: A retrospective case-control study was conducted on patients hospitalized between August 1, 2021, and July 31, 2023. The case group included 31 patients diagnosed with bloodstream infections, while the control group included 93 patients without bloodstream infections. The control group were matched to the case group at a 1:3 ratio using propensity score matching. Data were analyzed using the chi-square test, t-test, and logistic regression analysis. Results: The incidence density per 1,000 patient-days was 0.61 for HOBSI-1, 0.40 for HOBSI-2, and 0.25 for central line-associated bloodstream infections (CLABSI). Approximately 70%-80% of bloodstream infections were found to occur in general wards. Multivariate analysis revealed that prolonged hospital stays (odds ratio [OR] =1.03) and liver cirrhosis (OR = 14.76) were significant risk factors for PVC-associated bloodstream infection (PVC-BSI). The mortality rate in the case group was significantly higher, with a 22.08-fold increased risk compared to the control group. Conclusion: This study revealed that HOBSI had a higher incidence rate than CLABSI, with the majority of cases occurring in general wards. HOBSI surveillance demonstrated relatively higher sensitivity, which can be beneficial for identifying bloodstream infections in hospitals with low catheter usage. Given the high mortality risk, PVC-BSI require increased attention. This study provides valuable data for improving bloodstream infection prevention strategies.

Keywords

Acknowledgement

This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. NRF2020R1G1A1102533).

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