Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effects of Ginseng and Rehmanniae Radix Extracts on Alzheimer's Mice

알츠하이머병 생쥐모델에서 인삼과 생지황 추출물의 효과

  • Na Rae Yun (Department of Food & Biotechnology, College of Food Science, Woosuk University) ;
  • Jin Kwon (Department of Medical Rehabilitation engineering, School of Welfare Convergence, Hankyong National University) ;
  • Jong Uk Kim (Department of Acupuncture & Moxibustion, College of Korean Medicine, Woosuk University) ;
  • Chang Hyun Lee (Department of Anatomy, College of Korean Medicine, Woosuk University)
  • 윤나래 (우석대학교 식품과학대학 식품생명공학과) ;
  • 권진 (한경국립대학교 복지융합학부 의료재활공학) ;
  • 김종욱 (우석대학교 한의과대학 침구학교실) ;
  • 이창현 (우석대학교 한의학대학 해부학교실)
  • Received : 2025.08.23
  • Accepted : 2025.10.28
  • Published : 2025.10.25
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Abstract

This study evaluated the effects of Ginseng Radix and Rehmanniae Radix extracts on cognitive function and Alzheimer's disease(AD)-related biomarkers in APPswe/PSEN1dE9 transgenic mice. Behavioral testing, AChE activity assays, immunohistochemistry for β-amyloid, Tau protein, and CD68, as well as Western blot analyses, were performed. Ginseng Radix significantly improved cognitive performance in behavioral tests. Both Ginseng Radix and Rehmanniae Radix extracts reduced AChE activity, suggesting their potential to delay AD progression. Immunohistochemical analysis showed decreased β-amyloid and CD68 expression with Rehmanniae Radix, while combined treatment reduced Tau-protein levels. Western blot results further confirmed β-amyloid suppression by Ginseng Radix and Tau inhibition by the combined treatment. These findings suggest that Ginseng Radix may be more effective in enhancing cognitive function, while Rehmanniae Radix may play a greater role in modulating AD-related pathology.

Keywords

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