Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Anti-cancer Effects of Sargassum micracanthum Extract on Non-small Cell Lung Cancer Cells

잔가시모자반 추출물의 비소세포폐암 세포주에 대한 항암효과

  • Hyun-Ji Park (Department of Pathology, College of Korean Medicine, Dong-eui University) ;
  • Seon-Eun Park (Department of Pathology, College of Korean Medicine, Dong-eui University) ;
  • Gyoo-Yong Chi (Department of Pathology, College of Korean Medicine, Dong-eui University) ;
  • Yung-Hyun Choi (Department of Biochemistry, College of Korean Medicine, Dong-eui University) ;
  • Shin-Hyung Park (Department of Pathology, College of Korean Medicine, Dong-eui University)
  • 박현지 (동의대학교 한의과대학 병리학교실) ;
  • 박선은 (동의대학교 한의과대학 병리학교실) ;
  • 지규용 (동의대학교 한의과대학 병리학교실) ;
  • 최영현 (동의대학교 한의과대학 생화학교실) ;
  • 박신형 (동의대학교 한의과대학 병리학교실)
  • Received : 2025.07.21
  • Accepted : 2025.08.20
  • Published : 2025.10.25
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Abstract

Sargassum micracanthum (SM), a brown macroalga widely distributed along the Korean coastline, is known for its diverse pharmacological activities, including anti-inflammatory, antioxidant, and anticancer effects. While its ability to inhibit the migration and invasion of head and neck cancer cells has been reported, its cytotoxic activity against non-small cell lung cancer (NSCLC) cells remains largely unexplored. In this study, we evaluated the anticancer effects of an ethanolic extract of SM (ESM) on NSCLC cells, focusing on apoptosis induction. ESM significantly reduced the viability of H1299, PC9, and H1975 human NSCLC cells in a dose- and time-dependent manner. Treatment with ESM increased the sub-G1 cell population, annexin V-positive cells, and apoptotic nuclear condensation in a concentration-dependent fashion. ESM also upregulated cleaved PARP expression across all tested cell lines. Collectively, these findings indicate that ESM exerts anticancer effects in NSCLC cells by promoting apoptosis, highlighting its potential as a natural source for novel therapeutic agents against NSCLC.

Keywords

Acknowledgement

본 논문은 2024학년도 동의대학교 연구년 지원 및 동의대학교 교내특별연구과제 지원(과제번호 202500620001)에 의해 연구되었음.

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