Design & Manufacturing

Korean Society of Die & Mold Engineering (한국금형공학회)
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Analysis of cutting surface description and impurities for macular degeneration medicine by laser cutting

레이저 커팅에 의한 황반변성 치료제의 절단면 성상 및 유연물질 분석

  • Jeong-Won Lee (Regional Industry Innovation Department(Growth engine), Korea Institute of Industrial Technology) ;
  • Yong-Dae Kim (Regional Industry Innovation Department(Growth engine), Korea Institute of Industrial Technology) ;
  • Yong-Joon Choi (INNOBIZ Co., Ltd.)
  • 이정원 (한국생산기술연구원 지역산업혁신부문) ;
  • 김용대 (한국생산기술연구원 지역산업혁신부문) ;
  • 최용준 ((주)이노비즈)
  • Received : 2024.03.14
  • Accepted : 2024.03.31
  • Published : 2024.03.31
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Abstract

Macular degeneration is a disease in which the macula, the central part of the retina, is damaged and is one of the three major eye diseases along with glaucoma and diabetic retinopathy. Most of the optic cells and optic nerves are located here, and it is the most important place for vision as it is where images of objects are formed. The main symptom of macular degeneration is the inability to clearly distinguish the shape of objects or the ability to distinguish colors and light and dark. It is also a serious eye disease that causes black spots in the center of the field of vision. However, because it is difficult to distinguish from the form of vision loss caused by presbyopia, early diagnosis is often missed. The most commonly used treatment for macular degeneration is antibody injection therapy. This treatment requires regular injections once every 1 to 2 months. During antibody injection treatment, the fear of having to inject directly into the eye and the cost of repeated procedures over a long period of time are a great burden to patients. To overcome these problems, sustained-release preparations are being developed in special dosage forms using drug delivery systems. The drug release rate and release time can be adjusted, dramatically reducing the number of drug administrations. However, micro-implants (Ø0.46×6.0mm), which are sustained-release preparations, are highly brittle because biodegradable resin (PLGA) and therapeutic agent are mixed in a 4:6 ratio. Therefore, there is a high risk of it being damaged during handling. When physical force is applied to the micro-implant to cut it to a certain size, the cutting surface is rough and the length is not accurate. Therefore, in this study, laser cutting equipment was used to cut the micro-implant. In addition, the cutting surface properties according to the laser type were analyzed, and in particular, the content of flexible substances (Dexamethasone Acid, Dexamethasone Ketone, Dexamethasone Aldehyde) according to heat exposure was analyzed.

Keywords

Acknowledgement

본 연구는 한국생산기술연구원 기관주요사업 "제품생산 유연성 확보를 위한 뿌리공정기술 개발(KITECH EO-23-0008)" 의 지원으로 수행한 연구입니다.

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