Clinical Nutrition Research

  • 제13권4호
  • /
  • Pages.272-283
  • /
  • 2024
  • /
  • 2287-3732(pISSN)
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  • 2287-3740(eISSN)
한국임상영양학회 (The Korean Society of Clinical Nutrition)
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The Effect of Synbiotic Supplementation on Bone Complications, Anemia, and Gastrointestinal Function in Hemodialysis Patients: A Double-Blind Randomized Clinical Trial

  • Yasaman Azamian (Student Research Committee, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences) ;
  • Hadi Abdollahzad (Department of Nutrition, School of Medicine, Urmia University of Medical Sciences) ;
  • Shahab Rezaeian (Infectious Diseases Research Center, Health Institute, Kermanshah University of Medical Sciences) ;
  • Mohammad Hossein Rouhani (Nutrition and Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences) ;
  • Mohammad Hossein Fatehi (Department of Internal Medicine, Farabi Hospital, Isfahan University of Medical Sciences)
  • 투고 : 2024.07.23
  • 심사 : 2024.09.12
  • 발행 : 2024.10.30
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초록

Probiotics affect biomarkers indicative of bone formation, such as alkaline phosphatase (ALP), calcium status, bone mineralization, bone turnover markers and metabolism. This study aims to investigate the effects of synbiotic on gastrointestinal (GI) disorder, bone complications and anemia in hemodialysis (HD) patients. In this randomized, double-blind, placebo-controlled clinical trial study, HD patients received 2 symbiotic (n = 19) or placebo (n = 17) capsules daily for 12 weeks. GI function, serum levels of bone-specific biomarkers, and serum levels of anemia-specific biomarkers were assessed at the beginning and the end of study. GI function was assessed with gastrointestinal symptom rating scale questionnaire. The data were analyzed using SPSS. At the end of this study, parathyroid hormone levels decreased significantly in the synbiotic group (p = 0.039); however, in comparison to placebo group, the difference was not significant. Decrease of ALP levels in the synbiotic group were not statistically significant. However, a significant difference was seen between the 2 groups at the end of intervention (p = 0.037). Improvement in GI symptoms was observed in both groups, but the reduction rate was higher in the synbiotic group. Additionally, at the end of the study, a significant difference between the 2 groups was observed (p < 0.05). No statistically significant difference was observed in the levels of other factors within each group and between the 2 groups (p > 0.05). Symbiotic supplements after 12 weeks led to an improvement in GI function and ALP levels in HD patients. Further investigation into bone-mineral disorders in HD patients is necessary.

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과제정보

We would like to express our utmost gratitude and appreciation to the research committee of Kermanshah University of Medical Sciences. Also, we are grateful for all the assistance provided by the staff of the dialysis department at Farabi Hospital in Isfahan.

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