The Korean journal of internal medicine

  • 제39권5호
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  • Pages.813-822
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  • 2024
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  • 1226-3303(pISSN)
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  • 2005-6648(eISSN)
대한내과학회 (The Korean Association of Internal Medicine)
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Obesity is associated with incident chronic kidney disease in individuals with normal renal function

  • Su Hyun Song (Department of Internal Medicine, Chonnam National University Medical School) ;
  • Tae Ryom Oh (Department of Internal Medicine, Chonnam National University Medical School) ;
  • Sang Heon Suh (Department of Internal Medicine, Chonnam National University Medical School) ;
  • Hong Sang Choi (Department of Internal Medicine, Chonnam National University Medical School) ;
  • Chang Seong Kim (Department of Internal Medicine, Chonnam National University Medical School) ;
  • Seong Kwon Ma (Department of Internal Medicine, Chonnam National University Medical School) ;
  • Soo Wan Kim (Department of Internal Medicine, Chonnam National University Medical School) ;
  • Eun Hui Bae (Department of Internal Medicine, Chonnam National University Medical School)
  • 투고 : 2023.11.14
  • 심사 : 2024.05.02
  • 발행 : 2024.09.01
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초록

Background/Aims: Obesity has known to be a modifiable risk factor associated with worse outcomes in chronic kidney disease (CKD), but few studies have examined the impact of obesity on CKD incidence in the general population. The purpose of this study was to investigate the role of body mass index (BMI) and waist-to-hip ratio (WHR) as predictors of incident CKD and to evaluate the impact of weight reduction on CKD prevention. Methods: A total of 2,711 participants from a community-based cohort with normal renal function were prospectively analyzed. Among participants with obesity, we analyzed the change in WHR to evaluate the association of obesity reduction with CKD development. Results: During a mean follow-up of 11.03 ± 4.22 years, incident CKD occurred in 190 (7.0%) participants. In the fully adjusted multivariable Cox proportional hazard models, the risk of incident CKD increased with higher BMI (hazard ratio, 1.06; 95% confidence interval, 1.00-1.11; p = 0.033) and higher WHR (hazard ratio, 1.33; 95% confidence interval, 1.07-1.66; p = 0.009). In the Kaplan-Meier analysis, cumulative adverse renal events were significantly more common in the maintained obesity group than in the reduced obesity group (p = 0.001). Conclusions: Both higher BMI and WHR were associated with development of CKD, but the magnitude of the effect of WHR was higher than that of BMI. Moreover, reducing obesity would be beneficial for renal prognosis.

키워드

과제정보

The data used in this study were obtained from the Korean Genome and Epidemiology Study (KoGES; 6635-302), National Institute of Health, Korea Disease Control and Prevention Agency, Republic of Korea. The datasets analyzed in this study are available from the corresponding author on reasonable request. We thank Dr Jinseob Kim and Youngho Kim for providing technical support in data analysis.

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