Dementia and Neurocognitive Disorders (대한치매학회지)

Korean Dementia Association (대한치매학회)
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Korea-Registries to Overcome Dementia and Accelerate Dementia Research (K-ROAD): A Cohort for Dementia Research and Ethnic-Specific Insights

  • Hyemin Jang (Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine) ;
  • Daeun Shin (Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Yeshin Kim (Department of Neurology, Kangwon National University Hospital, Kangwon National University School of Medicine) ;
  • Ko Woon Kim (Department of Neurology, Jeonbuk National University Medical School and Hospital) ;
  • Juyoun Lee (Department of Neurology, Chungnam National University Hospital, School of Medicine, Chungnam National University) ;
  • Jun Pyo Kim (Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Hee Jin Kim (Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Soo Hyun Cho (Department of Neurology, Chonnam National University Hospital, Chonnam National University Medical School) ;
  • Si Eun Kim (Department of Neurology, Inje University College of Medicine, Haeundae Paik Hospital) ;
  • Duk. L. Na (Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Sang Won Seo (Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • K-ROAD Study Groups (K-ROAD Study Groups)
  • Received : 2024.09.23
  • Accepted : 2024.10.06
  • Published : 2024.10.31
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Abstract

Background and Purpose: Dementia, particularly Alzheimer's disease, is a significant global health concern, with early diagnosis and treatment development being critical goals. While numerous cohorts have advanced dementia research, there is a lack of comprehensive data on ethnic differences, particularly for the Korean population. The Korea-Registries to Overcome Dementia and Accelerate Dementia Research (K-ROAD) aims to establish a large-scale, hospital-based dementia cohort to address this gap, with a focus on understanding disease progression, developing early diagnostics, and supporting treatment advancements specific to the Korean population. Methods: K-ROAD comprises multiple prospective cohorts. Participants underwent clinical evaluations, neuroimaging, and biomarker analysis, with data collected on a range of clinical and genomic markers. Results: As of December 2023, K-ROAD has recruited over 5,800 participants, including individuals across the Alzheimer's clinical syndrome, subcortical vascular cognitive impairment, and frontotemporal dementia spectra. Preliminary findings highlight significant ethnic differences in amyloid positivity, cognitive decline, and biomarker profiles, compared to Western cohorts. Conclusions: The K-ROAD cohort offers a unique and critical resource for dementia research, providing insights into ethnic-specific disease characteristics and biomarker profiles. These findings will contribute to the development of personalized diagnostic and therapeutic approaches to dementia, enhancing global understanding of the disease.

Keywords

References

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