Allergy, Asthma & Respiratory Disease

  • 제12권1호
  • /
  • Pages.9-16
  • /
  • 2024
  • /
  • 2288-0402(pISSN)
  • /
  • 2288-0410(eISSN)
대한천식알레르기학회 (The Korean Academy of Asthma, Allergy and Clinical Immunology)
권호 표지
DOI QR코드

DOI QR Code

면역글로불린 E 매개 밀 알레르기의 업데이트

Update of immunoglobulin E-mediated wheat allergy

  • 황윤하 (부산성모병원 소아청소년과) ;
  • 김정희 (인하대학교 의과대학 소아청소년과학교실)
  • Yoonha Hwang (Department of Pediatrics, Busan St. Mary's Hospital) ;
  • Jeong Hee Kim (Department of Pediatrics, Inha University Hospital, Inha University College of Medicine)
  • 투고 : 2023.11.13
  • 심사 : 2023.11.24
  • 발행 : 2024.01.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Wheat allergy is one of the common causes of food allergies in children. The prevalence varies by age and country, and is known to be 0.04%-0.97% globally and 0.2%-1.3% in Korea. Wheat allergy usually appears with skin symptoms within 2 hours after ingestion, and in severe cases, it causes systemic symptoms and anaphylaxis. Wheat-dependent exercise-induced anaphylaxis, a serious wheat allergy, may occur after wheat consumption along with cofactors, such as exercise, alcohol, aspirin and/or nonsteroidal anti-inflammatory drugs. Wheat allergy is confirmed by oral food challenge. However, the challenging test is difficult to perform, although it is a confirmative diagnostic method. With the development of component resolved diagnostics, ω-5 gliadin specific immunoglobulin E (sIgE) along with wheat sIgE are useful for diagnosis of it. Wheat allergy should be differentiated from oral mite anaphylaxis or cross-reactivity to grass pollen allergy. It is recommended to avoid foods containing wheat, however, recently, efforts are being made to improve quality of life with oral immunotherapy.

키워드

참고문헌

  1. Warren CM, Jiang J, Gupta RS. Epidemiology and burden of food allergy. Curr Allergy Asthma Rep 2020;20:6.
  2. Korea Flour Mills Industrial Association. Annual per capita flour consumption [Internet]. Seoul (Korea): Korea Flour Mills Industrial Association; [cited 2023 Nov 11]. Available from: http://www.kofmia.org.
  3. Matsuo H, Yokooji T, Taogoshi T. Common food allergens and their IgE-binding epitopes. Allergol Int 2015;64:332-43.
  4. Liu W, Wu Y, Wang J, Wang Z, Gao J, Chen H, et al. A meta-analysis of the prevalence of wheat allergy worldwide. Nutrients 2023;15:1564.
  5. Jung YH, Ko H, Kim HY, Soe JH, Kwon JW. Prevalence and risk factors of food allergy in preschool in Seoul. Korean J Asthma Allergy Immunol 2011;31:177-83.
  6. Lee AH, Kim KE, Lee KE, Kim SH, Wang TW, Kwak TK, et al. Prevalence of food allergy and perception on food allergen labelling in school foodservice among Korean students. Allergy Asthma Respir Dis 2013;1:227-34.
  7. Park JY, Park GY, Han YS, Shin MY. Survey of food allergy in elementary school children in Bucheon-city and relationship between food allergy and other allergic diseases. Allergy Asthma Respir Dis 2013;1:266-73.
  8. Jeong K, Kim J, Ahn K, Lee SY, Min TK, Pyun BY, et al. Age-based causes and clinical characteristics of immediate-type food allergy in Korean children. Allergy Asthma Immunol Res 2017;9:423-30.
  9. Lee EJ, Jeong K, Shin YS, Nahm DH, Park HS, Lee S, et al. Causes of food allergy according to age and severity: a recent 10-year retrospective study from a single tertiary hospital. Allergy Asthma Respir Dis 2020;8:80-8.
  10. Lee SY, Ahn K, Kim J, Jang GC, Min TK, Lee S, et al. A multicenter retrospective case study of anaphylaxis triggers by age in Korean children. Allergy Asthma Immunol Res 2016;8:535-40.
  11. Radauer C, Breiteneder H. Evolutionary biology of plant food allergens. J Allergy Clin Immunol 2007;120:518-25.
  12. Inomata N. Wheat allergy. Curr Opin Allergy Clin Immunol 2009;9:238-43.
  13. Morita E, Matsuo M, Chinuki Y, Takahashi H, Dahlstrom J, Tanaka A. Food-dependent exercise-induced anaphylaxis - importance of omega-5 gliadin and HMW-glutenin as causative antigens for wheat-dependent exercise-induced anaphylaxis. Allergol Int 2009;58:493-8.
  14. Takahashi H, Matsuo H, Chinoku Y, Kohno K, Tanaka A, Morita E, et al. Recombinant high molecular weight-glutenin subunit-specific IgE detections is useful in identifying wheat-dependent exercise-induced anaphylaxis complementary to recombinant omega-5 gliadin-specific IgE test. Clin Exp Allergy 2012;42:1293-8.
  15. Quirce S, Diaz-Perales A. Diagnosis and management of grain-induced asthma. Allergy Asthma Immunol Res 2013;5:348-56.
  16. Quirce S, Boyano-Martinez T, Diaz-Perales A. Clinical presentation, allergens, and management of wheat allergy. Expert Rev Clin Immunol 2016;12:563-72.
  17. Jones SM, Magnolfi CF, Cooke SK, Sampson HA. Immunologic cross-reactivity among cereal grains and grasses in children with food hypersensitivity. J Allergy Clin Immunol 1995;96:341-51.
  18. Pastorello EA, Farioli L, Conti A, Pravettoni V, Bonomi S, Iametti S, et al. Wheat IgE-mediated food allergy in European patients: alpha-amylase inhibitors, lipid transfer proteins and low-molecular-weight glutenins. Allergenic molecules recognized by double-blind, placebo-controlled food challenge. Int Arch Allergy Immunol 2007;144:10-22.
  19. Komata T, Soderstrom L, Borres MP, Tachimoto H, Ebisawa M. Usefulness of wheat and soybean specific IgE antibody titers for the diagnosis of food allergy. Allergol Int 2009;58:599-603.
  20. Sampson HA. Utility of food-specific IgE concentrations in predicting symptomatic food allergy. J Allergy Clin Immunol 2001;107:891-6.
  21. Nilsson N, Sjolander S, Baar A, Berthold M, Pahr S, Hedlin G, et al. Wheat allergy in children evaluated with challenge and IgE antibodies to wheat components. Pediatr Allergy Immunol 2015;26:119-25.
  22. Graham F, Caubet JC, Ramadan S, Spoerl D, Eigenmann PA. Specific IgE decision point cutoffs in children with IgE mediated wheat allergy and a review of the literature. Int Arch Allergy Immunol 2020;181:296-300.
  23. Ebisawa M, Shibata R, Sato S, Borres MP, Ito K. Clinical utility of IgE antibodies to ω-5 gliadin in the diagnosis of wheat allergy: a pediatric multicenter challenge study. Int Arch Allergy Immunol 2012;158:71-6.
  24. Makela MJ, Eriksson C, Kotaniemi-Syrjanen A, Palosuo K, Marsh J, Borres M, et al. Wheat allergy in children - new tools for diagnostics. Clin Exp Allergy 2014;44:1420-30.
  25. Ito K, Futamura M, Borres MP, Takaoka Y, Dahlstrom J, Kohno K, et al. IgE antibodies to ω-5 gliadin associated with immediate symptoms on oral wheat challenge in Japanese children. Allergy 2008;63:1536-42.
  26. Yoon J, Jeong K, Lee S. Usefulness of specific IgE antibody levels to wheat, gluten, and ω-5 gliadin for wheat allergy in Korean children. Allergy Asthma Respir Dis 2016:4:119-25.
  27. Shibata R, Nishima S, Tanaka A, Borres MP, Morita E. Usefulness of specific IgE antibodies to ω-5 gliadin in the diagnosis and follow-up of Japanese children with wheat allergy. Ann Allergy Asthma Immunol 2011;107:337-43.
  28. Sindher S, Long AJ, Purington N, Chollet M, Slatckin S, Andorf S, et al. Analysis of a large standized food challenge data set to determine predictors of positive outcome across multiple allergens. Front Immunol 2018;9:2689.
  29. Schoos AM, Chawes BL, Folsgaard NV, Samandari N, Bonnelykke K, Bisgaard H. Disagreement between skin prick test and specific IgE in young children. Allergy 2015;70:41-8.
  30. Song TW, Kim KW, Kim WK, Kim JH, Kim HH, Pyun BY, et al. Guidelines for the oral food challenges in children. Pediatr Allergy Respir Dis (Korea) 2012;22:3-20.
  31. Takahashi K, Taniguchi M, Fukutomi Y, Sekiya K, Watai K, Akiyama K, et al. Oral mite anaphylaxis caused by mite-contaminated okonomiyaki/pancake-mix in Japan: 8 case reports and a review of 28 reported cases. Allergol Int 2014;63:51-6.
  32. King AL, Ciclitira PJ. Celiac disease. Curr Opin Gastroenterol 2000;16:102-6.
  33. Ebisawa M, Ito K, Fujisawa T. Japanese guidelines for food allergy 2020. Allergol Int 2020;69:370-86.
  34. Baar A, Pahr S, Constantin C, Giavi S, Manoussaki A, Valenta R, et al. Specific IgE reactivity to Tri a 36 in children with wheat food allergy. J Allergy Clin Immunol 2014;133:585-7.
  35. Akdis CA, Akdis M. Mechanisms of allergen-specific immunotherapy. J Allergy Clin Immunol 2011;127:18-27.
  36. Pepper AN, Assa'ad A, Blaiss M, Brown E, Chinthrajah S, Casale TB, et al. Consensus report from the Food Allergy Research & Education (FARE) 2019 oral immunotherapy for food allergy summit. J Allergy Clin Immunol 2020;146:244-9.
  37. Nucera E, Pollastrini E, De Pasquale T, Buonomo A, Roncallo C, Lombardo C, et al. New protocol for desensitization to wheat allergy in a single case. Dig Dis Sci 2005;50:1708-9.
  38. Sato S, Utsunomiya T, Imai T, Yanagida N, Asaumi T, Ogura K, et al. Wheat oral immunotherapy for wheat-induced anaphylaxis. J Allergy Clin Immunol 2015;136:1131-3.
  39. Okada Y, Yanagida N, Sato S, Ebisawa M. Better management of wheat allergy using a very low-dose food challenge: a retrospective study. Allergol Int 2016;65:82-7.
  40. Nagakura KI, Yanagida N, Sato S, Nishino M, Takahashi K, Asaumi T, et al. Low-dose-oral immunotherapy for children with wheat-induced anaphylaxis. Pediatr Allergy Immunol 2020;31:371-9.
  41. Nowak-Wegrzyn A, Wood RA, Nadeau KC, Pongracic JA, Henning AK, Lindblad RW, et al. Multicenter, randomized, double-blind, placebo-controlled clinical trial of vital wheat gluten oral immunotherapy. J Allergy Clin Immunol 2019;143:651-61.
  42. Ogura K, Yanagida N, Sato S, Imai T, Ito K, Kando N, et al. Evaluation of oral immunotherapy efficacy and safety by maintenance dose dependency: a multicenter randomized study. World Allergy Organ J 2020;13:100463.
  43. Vickery BP, Berglund JP, Burk CM, Fine JP, Kim EH, Kim JI, et al. Early oral immunotherapy in peanut-allergic preschool children is safe and highly effective. J Allergy Clin Immunol 2017;139:173-81.
  44. Chu DK, Wood RA, French S, Fiocchi A, Jordana M, Waserman S, et al. Oral immunotherapy for peanut allergy (PACE): a systematic review and meta-analysis of efficacy and safety. Lancet 2019;393:2222-32.
  45. Zuberbier T, Wood RA, Bindslev-Jensen C, Fiocchi A, Chinthrajah RS, Tassinari P, et al. Omalizumab in IgE-mediated food allergy: a systematic review and meta-analysis. J Allergy Clin Immunol Pract 2023;11:1134-46.
  46. Koike Y, Yanagida N, Sato S, Asaumi T, Ogura K, Ebisawa M, et al. Predictors of persistent wheat allergy in children: a retrospective cohort study. Int Arch Allergy Immunol 2018;176:249-5.
  47. Ahrens B, Sampson HA, Beyer K. Adverse reactions to food. Pediatr Allergy Immunol 2012;21:421-8.
  48. Mansouri M, Pourpak Z, Mozafari H, Gorji FA, Shoormasti RS. Follow-up of the wheat allergy in children; consequences and outgrowing the allergy. Iran J Allregy Asthma Immunol 2012;11:157-63.
  49. Keet CA, Matsui EC, Dhillon G, Lenehan P, Paterakis M, Wood RA. The natural history of wheat allergy. Ann Allergy Asthma Immunol 2009;102:410-5.
  50. Kotaniemi-Syrjanen A, Palosuo K, Jartti T, Kuitunen M, Pelkonen AS, Makelaa MJ. The prognosis of wheat hypersensitivity in children. Pediatr Allergy Immunol 2010;21(2 Pt 2):e421-8.