The Journal of the Convergence on Culture Technology (문화기술의 융합)

The International Promotion Agency of Culture Technology (국제문화기술진흥원)
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Observations on the polymerization reaction of cyanoacrylate-lipiodol mixture glues

시아노아크릴레이트-리피오돌 혼합 글루의 중합반응 관찰

  • 이경민 (을지대학교 의료공학) ;
  • 정윤수 (을지대학교 의료공학과) ;
  • 정현우 (을지대학교 의료공학과) ;
  • 박상수 (을지대학교 의료공학과)
  • Received : 2024.09.20
  • Accepted : 2024.11.01
  • Published : 2024.11.30
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Abstract

Cyanoacrylate glue has the property of sticking to human tissue as it reacts with anions in human body fluids and hardens through a polymerization reaction. It was developed as an adhesive for epidermal bonding, but is also widely used in clinical practice for vascular embolization to occlude blood vessels that are bleeding or at risk of bleeding. In vascular embolization, it is necessary to control the curing speed according to the size of the blood vessel and the speed of blood flow, and to achieve this, the speed of the polymer reaction is adjusted by mixing with lipiodol. In this study, we prepared the mixed solutions of industrial ethylcyatoacrylate and medical n-butyl cyanoacrylate glues with Lipiodol and poppy seed oil, the raw material of Lipiodol. Video was filmed of the process in which each cyanoacrylate glue and lipiodol mixture hardened on the surface of the aqueous solution and turned into a solid. When the cyanoacrylate glue came into contact with the surface of the aqueous solution, polymerization occurred immediately at the interface, forming a disk-shaped solid. As the monomers inside the disk escaped and came into contact with the aqueous solution, the secondary polymerization reaction proceeded slowly. NBCA's polymerization reaction time was about 1 minute, increased to about 2 minutes when Lipiodol was 50%, and to about 4 minutes when it was 67%. These observation results are expected to be very useful in understanding vascular occlusion in clinical embolization.

시아노아크릴레이트 글루는 인체 체액 중의 음이온과 반응하여 고분자 반응이 일어나 경화되면서 인체 조직에 달라붙는 성질을 가지고 있다. 표피접합용 접착제로 개발되었으나, 임상에서는 출혈 중이거나 출혈 위험이 있는 혈관의 폐색을 위한 혈관색전술에도 많이 이용되고 있다. 혈관 색전술에서는 혈관의 크기와 혈류의 속도에 따라 경화속도의 조절이 필요하며, 이룰 위해 리피오돌과 혼합하여 고분자 반응의 속도를 조절한다. 본 연구에서는 공업용 에틸시아노아크릴레이트, n-부틸 시아노아크릴레이트, 리피오돌, 그리고 리피오돌의 원료인 양귀비 씨앗 오일 혼합용액을 제조하였다. 각각의 시아노아크릴레이트 글루와 리피오돌 혼합액수용액의 표면에서 경화되어 고체로 변화하는 과정을 동영상을 촬영하여 분석하였다. 시아노아크릴레이트 글루는 수용액 표면과 접촉하면서 계면에서 즉시 중합반응이 일어나 원반형의 고체가 만들어졌으며 원반 내부의 단량체들이 빠져 나가면서 수용액과 접촉하면서 2차 중합반응이 천천히 진행되었다. NBCA의 고분자 반응시간은 약 1분이었고, 리피오돌이 50% 일 때 약 2분으로 증가하며 67%일 때는 약 4분으로 반응속도가 느려졌다. 이러한 관찰 결과는 임상 색전술의 혈관 폐색을 이해하는데 매우 유용할 것으로 기대된다.

Keywords

Acknowledgement

본 연구는 2024년도 을지대학교 교육혁신지원 사업으로 연구되었음

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