한방재활의학과학회지 (Journal of Korean Medicine Rehabilitation)

  • 제34권4호
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  • Pages.41-52
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  • 2024
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  • 1229-1854(pISSN)
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  • 2288-4114(eISSN)
한방재활의학과학회 (The society of Korean Medicine Rehabilitation)
권호 표지
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최근 10년간 하지불안증후군의 한의학 치료에 대한 국내외 임상 연구 동향

A Recent 10 Years Clinical Research Trend of Korean Medicine for Restless Legs Syndrome

  • 최현진 (경희대학교 대학원 임상한의학과) ;
  • 안상준 (경희대학교 대학원 임상한의학과) ;
  • 신우철 (경희대학교 대학원 임상한의학과) ;
  • 조재흥 (경희대학교 대학원 임상한의학과) ;
  • 정원석 (경희대학교 대학원 임상한의학과) ;
  • 송미연 (경희대학교 대학원 임상한의학과) ;
  • 김형석 (경희대학교 대학원 임상한의학과)
  • Hyunjin Choi (Department of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Sang-joon An (Department of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Woochul Shin (Department of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Jae-Heung Cho (Department of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Won-Seok Chung (Department of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Mi-Yeon Song (Department of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Hyungsuk Kim (Department of Clinical Korean Medicine, Graduate School, Kyung Hee University)
  • 투고 : 2023.12.19
  • 심사 : 2024.03.25
  • 발행 : 2024.10.31
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초록

Objectives This study aims to analyze clinical studies of restless legs syndrome (RLS) and suggest future direction of clinical study on RLS. Methods We used five Korean and three global electronic databases to search clinical studies about RLS from 2013 to 2023. Only clinical studies were selected for this study. Studies which are not relevant with RLS, are not clinical study, are not about RLS Korean medicine, or does not have accessible full text were excluded. Results Total twenty studies were finally included in this study. Case reports are the most frequently used study design. With regard to intervention, herbal medicine was the most frequently used one. All studies used international restless legs scale for evaluating symptom severities of RLS. All studies showed improvement on RLS symptoms. Conclusions Further studies with high level of evidence such as randomized controlled trial or cohort study will be needed in the future on RLS.

키워드

참고문헌

  1. Ekbom KA. Restless legs. Acta Medica Scandinavica. 1945;158:4-122. 
  2. Allen RP, Picchietti DL, Garcia-Borreguero D, Ondo WG, Walters AS, Winkelman JW, Zucconi M, Ferri R, Trenkwalder C, Lee HB; International Restless Legs Syndrome Study Group. Restless legs syndrome/Willis- Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria-history, rationale, description, and significance. Sleep Medicine. 2014;15(8):860-73.  https://doi.org/10.1016/j.sleep.2014.03.025
  3. Garcia-Borreguero D, Kohnen R, Silber MH, Winkelman JW, Earley CJ, Hogl B, Manconi M, Montplaisir J, Inoue Y, Allen RP. The long-term treatment of restless legs syndrome/Willis-Ekbom disease: evidence-based guidelines and clinical consensus best practice guidance: a report from the International Restless Legs Syndrome Study Group. Sleep Medicine. 2013;14(7):675-84.  https://doi.org/10.1016/j.sleep.2013.05.016
  4. Abetz L, Allen R, Follet A, Washburn T, Earley C, Kirsch J, Knight H. Evaluating the quality of life of patients with restless legs syndrome. Clinical Therapeutics. 2004;26(6):925-35.  https://doi.org/10.1016/S0149-2918(04)90136-1
  5. Ghorayeb I, Tison F. Epidemiology of restless legs syndrome. Revue Neurologique. 2009;165(8-9):641-9.  https://doi.org/10.1016/j.neurol.2009.02.006
  6. Michaud M, Chabli A, Lavigne G, Montplaisir J. Arm restlessness in patients with restless legs syndrome. Movement Disorders: Official Journal of the Movement Disorder Society. 2000;15(2):289-93.  https://doi.org/10.1002/1531-8257(200003)15:2<289::AID-MDS1012>3.0.CO;2-E
  7. Montplaisir J, Boucher S, Poirier G, Lavigne G, Lapierre O, Lesperance P. Clinical, polysomnographic, and genetic characteristics of restless legs syndrome: a study of 133 patients diagnosed with new standard criteria. Movement Disorders: Official Journal of the Movement Disorder Society. 1997;12(1):61-5.  https://doi.org/10.1002/mds.870120111
  8. Allen RP, Picchietti D, Hening WA, Trenkwalder C, Walters AS, Montplaisi J; Restless Legs Syndrome Diagnosis and Epidemiology workshop at the National Institutes of Health; International Restless Legs Syndrome Study Group. Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Medicine. 2003;4(2):101-19.  https://doi.org/10.1016/S1389-9457(03)00010-8
  9. Berger K, Luedemann J, Trenkwalder C, John U, Kessler C. Sex and the risk of restless legs syndrome in the general population. Archives of Internal Medicine. 2004;164(2):196-202.  https://doi.org/10.1001/archinte.164.2.196
  10. Brostrom A, Alimoradi Z, Lind J, Ulander M, Lundin F, Pakpour A. Worldwide estimation of restless legs syndrome: a systematic review and meta-analysis of prevalence in the general adult population. Journal of Sleep Research. 2023;32(3):e13783. 
  11. Phillips B, Young T, Finn L, Asher K, Hening WA, Purvis C. Epidemiology of restless legs symptoms in adults. Archives of Internal Medicine. 2000;160(14):2137-41.  https://doi.org/10.1001/archinte.160.14.2137
  12. Batool-Anwar S, Li Y, De Vito K, Malhotra A, Winkelman J, Gao X. Lifestyle factors and risk of restless legs syndrome: prospective cohort study. Journal of Clinical Sleep Medicine. 2016;12(2):187-94.  https://doi.org/10.5664/jcsm.5482
  13. Earley CJ, Silber MH. Restless legs syndrome: understanding its consequences and the need for better treatment. Sleep Medicine. 2010;11(9):807-15.  https://doi.org/10.1016/j.sleep.2010.07.007
  14. Cho YW, Shin WC, Yun CH, Hong SB, Kim JH, Allen RP, Earley CJ. Epidemiology of restless legs syndrome in Korean adults. Sleep. 2008;31(2):219-23.  https://doi.org/10.1093/sleep/31.2.219
  15. Kim TH, Jung JH, Choi YH, Kim BK. Research trend of traditional Chinese medicine in the treatment of restless legs syndrome. Journal of Oriental Neuropsychiatry. 2014;25(2):165-78.  https://doi.org/10.7231/JON.2014.25.2.165
  16. Trenkwalder C, Hening WA, Montagna P, Oertel WH, Allen RP, Walters AS, Costa J, Stiasny-Kolster K, Sampaio C. Treatment of restless legs syndrome: an evidence-based review and implications for clinical practice. Movement Disorders: Official Journal of the Movement Disorder Society. 2008;23(16):2267-302.  https://doi.org/10.1002/mds.22254
  17. Bega D, Malkani R. Alternative treatment of restless legs syndrome: an overview of the evidence for mind-body interventions, lifestyle interventions, and neutraceuticals. Sleep Medicine. 2016;17:99-105.  https://doi.org/10.1016/j.sleep.2015.09.009
  18. Kwon S, Jin C, Cho SY, Park SU, Jung WS, Moon SK, Park JM, Ko CN, Cho KH. Paeoniae Radix-containing herbal medicine for patients with restless legs syndrome: a systematic review and meta-analysis. Complementary Therapies in Clinical Practice. 2019;35:329-41.  https://doi.org/10.1016/j.ctcp.2019.03.015
  19. Huang C, Tang JF, Sun W, Wang LZ, Jin YS. Effectiveness of acupuncture in the management of restless leg syndrome: a systematic review and meta-analysis. Annals of Palliative Medicine. 2021;10(10):10495-505.  https://doi.org/10.21037/apm-21-2309
  20. Harrison EG, Keating JL, Morgan PE. Non-pharmacological interventions for restless legs syndrome: a systematic review of randomised controlled trials. Disability and Rehabilitation. 2019;41(17):2006-14.  https://doi.org/10.1080/09638288.2018.1453875
  21. Raissi GR, Forogh B, Ahadi T, Ghahramanpoori S, Ghaboussi P, Sajadi S. Evaluation of acupuncture in the treatment of restless legs syndrome: a randomized controlled trial. Journal of Acupuncture and Meridian Studies. 2017;10(5):346-50.  https://doi.org/10.1016/j.jams.2017.08.004
  22. Lee YJ, Lee JE, Kim SJ, Yoo JH. The study on effect of Korean medical treatment for patients with restless legs syndrome. Journal of Oriental Neuropsychiatry. 2015;26(4):357-64.  https://doi.org/10.7231/JON.2015.26.4.357
  23. Li S, Liu Q, Zhang S, Zhu M, Hu Y, Cao X, Li W. Effective and safety analysis of electroacupuncture treatment for restless legs syndrome in maintenance hemodialysis patients. Acupuncture & Electro-Therapeutics Research. 2021;46(2):159-70.  https://doi.org/10.3727/036012921X16164310686833
  24. Pan W, Wang M, Li M, Wang Q, Kwak S, Jiang W, Yamamoto Y. Actigraph evaluation of acupuncture for treating restless legs syndrome. Evidence-Based Complementary and Alternative Medicine. 2015;2015:343201. 
  25. Qu K, Xue K, Ma Y. Treatment of primary restless legs syndrome with Fu's subcutaneous needling: a case report. Explore: The Journal of Science & Healing. 2024;20(2):253-5.  https://doi.org/10.1016/j.explore.2023.08.017
  26. Park WH, Cha YY. Effect of acupuncture and massage on iliopsoas muscle in patients with restless leg syndrome: case report. J Korean Med Rehabil. 2013;23(2):163-74. 
  27. Kim JY, Lee JW, Oh HW, Lee JH, Lee EJ, Koh BH. A case study of soyangin patient with restless legs syndrome treated with Hyeongbangsabaeksan. Journal of Sasang Constitutional Medicine. 2015;27(4):419-28.  https://doi.org/10.7730/JSCM.2015.27.4.419
  28. Ahn S, Hong J, Choo W, Lee S, Shin S, Choi Y. A case report on post spinal surgery syndrome in restless leg syndrome. The Journal of Internal Korean Medicine. 2016;37(5):717-25.  https://doi.org/10.22246/jikm.2016.37.5.717
  29. Kim KR, Lee JH. A case report of treating restless legs syndrome in children by oriental medicine. The Journal of Pediatrics of Korean Medicine. 2018;32(4):113-20.  https://doi.org/10.7778/JPKM.2018.32.4.113
  30. Yim TB, Jeon GR, Lee HJ, Kim SY, Cho SY, Park SU, Ko CN, Park JM. A case report of patient with restless legs syndrome improved by Gami Ssanghwa-tang. The Journal of the Society of Stroke on Korean Medicine. 2021;22(1):1-10. 
  31. Fukutome T, Murashima K. Effects of acupuncture on sensory symptoms and motor signs in patients with restless legs syndrome: a crossover randomized controlled trial. Medicine. 2022;101(51):e32317. 
  32. Kim G, Suh W, Kim S, Jung W, Mun S, Kwon S, Cho K. A case report on heat sensation in both feet caused by restless leg syndrome using conservative Korean medical treatment. The Journal of Internal Korean Medicine. 2018;39(2):116-29.  https://doi.org/10.22246/jikm.2018.39.2.116
  33. Yang J, Kim S, Lee Y, Cho K, Moon S, Jung W, Kwon S. A case of restless legs syndrome patient with numbness in both soles using Gyejibokryeong-hwan. The Journal of Internal Korean Medicine. 2019;40(2):270-8.  https://doi.org/10.22246/jikm.2019.40.2.270
  34. Ko J , Lee C, L im H , Joo C, L ee S . A case report o f combined treatment including bee venom injection for restless leg syndrome patient with lower extremity discomfort. Journal of Sports Korean Medicine & Clinical Pharmacopuncture. 2020;20(1):53-63.  https://doi.org/10.51321/jskmcp.2020.20.1.53
  35. Lee J, Jun H, Cheon H, Joo S, Seo S, Yeum H. A case of Korean complex treatment for a patient with restless legs syndrome complaining of abnormal sense in both legs after a traffic accident. Journal of Spine & Joint Korean Medicine. 2022;19(1):133-47. 
  36. Fukutome T. Acupuncture point injection markedly improved sensory symptoms and motor signs in 2 patients with restless legs syndrome. Clinical Case Reports. 2018;6(7):1353-7.  https://doi.org/10.1002/ccr3.1619
  37. Heo J, Lee W, Jeong J. A case report of migraine and a case report of restless legs syndrome treated with Osuyu-tang based on Shanghanlun Provisions. Journal of Korean Medical Association of Clinical Sanghan-Geumgwe. 2019;11(1):125-38. 
  38. Ko J , Kim S, Yeum H, Lee S, Kim Y, Choi D. A case report: bee venom acupuncture for a restless leg syndrome patient with sleep disturbance. Journal of Spine & Joint Korean Medicine. 2018;15(1):85-100. 
  39. Seo Y, Jin C, Jang BH, Jeon JP, Lee YS, Yang SB, Jung WS, Moon SK, Cho KH, Kwon S. Successful treatment of restless leg syndrome with the traditional herbal medicines Dangguijakyak-san and Shihogyeji-tang: a case report (CARE-compliant). Medicine. 2021;100(31):e26800. 
  40. Jung SM, Lee SW, Lee HG, Cho KH, Moon SK, Jung WS, Kwon S. Case of restless leg syndrome patient with chronic kidney failure treated with Jakyakgamcho-tang. The Journal of Internal Korean Medicine. 2023;44(2):146-57.  https://doi.org/10.22246/jikm.2023.44.2.146
  41. Winkelman JW, Redline S, Baldwin CM, Resnick HE, Newman AB, Gottlieb DJ. Polysomnographic and health-related quality of life correlates of restless legs syndrome in the Sleep Heart Health Study. Sleep. 2009;32(6):772-8.  https://doi.org/10.1093/sleep/32.6.772
  42. Comella CL. Restless legs syndrome: treatment with dopaminergic agents. Neurology. 2002;58(4 suppl 1):S87-92.  https://doi.org/10.1212/WNL.58.suppl_1.S87
  43. Yang JG, Kim DH, Lee JH, P ark KH, Jung KY, Shin WC, Cho YW. The reliability and validity of the Korean versions of the international restless legs scale and the restless legs syndrome quality of life questionnaire. Journal of the Korean Neurological Association. 2010;28(4):263-9.