Journal of Industrial Convergence (산업융합연구)

DAEHAN Society of Industrial Management (대한산업경영학회)
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Inhibitory Effect of Brussels Sprouts Extract on Proliferation of Various Types of Cancer Cells

방울양배추 추출물의 다양한 종류 암세포 증식 저해 효과

  • Jae-Hyeok Lee (Department of Emergency Medical Rescue, Nambu University) ;
  • Jeong-Sook Park (Department of Nursing, Nambu University)
  • 이재혁 (남부대학교 응급구조학과) ;
  • 박정숙 (남부대학교 간호학과)
  • Received : 2024.07.30
  • Accepted : 2024.10.20
  • Published : 2024.10.28
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Abstract

This study was conducted to examine the effect of Brussels sprout extract on the proliferation of various cancer cells and to examine the degree of inhibition of proliferation. The six cell lines used in the experiment were human-derived cancer cell lines: prostate cancer cells DU-145, lung cancer cells A549, breast cancer cells MCF-7, uterine cancer cells HeLa, biliary tract cancer cells SNU-1196, and liver cancer cells SNU-182. Inhibition of cancer cell proliferation was measured using the CCK-8 assay. As a result of examining the inhibition of cancer cell proliferation by 1ug/mL, 10ug/mL, and 100ug/mL of Brussels sprout extract, lung cancer cell A549 and uterine cancer cell HeLa showed significant proliferation inhibition at 10ug/mL and 100ug/mL of Brussels sprout extract, and biliary tract Cancer cells SNU-1196 showed significant inhibition of proliferation at 1ug/mL, 10ug/mL, and 100ug/mL of Brussels sprout extract. These results suggest that Brussels sprout extract may have potential anticancer effects against various types of cancer cells.

본 연구는 방울양배추 추출물의 다양한 암세포 증식에 미치는 영향을 살펴보고 증식 저해 정도를 살펴보기 위하여 실시되었다. 실험에 사용한 세포주는 6종이며 전립샘암 세포주인 DU-145, 폐암 세포주인 A549, 유방암 세포주인 MCF-7, 자궁암 세포주인 HeLa, 담도암 세포주인 SNU-1196, 간암 세포주인 SNU-182 로 모두 인체에서 유래된 암 세포주를 사용하였다. 암세포의 증식 저해는 CCK-8 assay를 이용하여 측정하였다. 방울양배추 추출물 1ug/mL, 10ug/mL, 100ug/mL에 대한 암세포 증식 저해를 살펴본 결과 폐암세포 A549, 자궁암세포 HeLa는 방울양배추 추출물 10ug/mL, 100ug/mL에서 유의한 증식 저해를 보여주었으며, 담도암세포 SNU-1196는 방울양배추 추출물 1ug/mL, 10ug/mL, 100ug/mL에서 유의한 증식 저해를 보였다. 이러한 결과는 방울양배추 추출물이 다양한 종류의 암세포에 대해 잠재적인 항암 효과를 가질 수 있음을 시사한다.

Keywords

Acknowledgement

This paper was supported by Nambu University in 2022.

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