Animal Bioscience

Asian Australasian Association of Animal Production Societies (아세아태평양축산학회)
권호 표지
DOI QR코드

DOI QR Code

Effect of dietary β-mannanase supplementation on growth performance, intestinal morphology, digesta viscosity, and nutrient utilization in broiler chickens: Meta-analysis and meta-regression

  • Hyun Woo Kim (Department of Animal Science and Technology, Chung-Ang University) ;
  • Chan Ho Kwon (Department of Animal Science and Technology, Chung-Ang University) ;
  • Ji Hye Lee (Department of Animal Science and Technology, Chung-Ang University) ;
  • Min Sung Kang (Department of Animal Science and Technology, Chung-Ang University) ;
  • Dong Yong Kil (Department of Animal Science and Technology, Chung-Ang University)
  • Received : 2024.07.02
  • Accepted : 2024.08.14
  • Published : 2024.12.01
Download PDF
⟨ Previous Next ⟩

Abstract

Objective: The present study aimed to investigate the effectiveness of dietary β-mannanase supplementation on growth performance, intestinal morphology, digesta viscosity, and dietary nutrient utilization in broiler chickens through a meta-analysis. The effects were further examined by a meta-regression analysis with activity levels of β-mannanase in broiler diets. Methods: A total of 23 studies, which were conducted in 11 countries and completed between December 2003 and August 2023, were selected for this meta-analysis. The standardized mean difference and its 95% confidence interval were calculated as the effect size metrics using random effect model, with I2 value being utilized to measure heterogeneity. Investigated measurements included body weight gain (BWG), feed intake, feed conversion ratio (FCR), villus height (VH), crypt depth (CD), VH:CD ratio, digesta viscosity, nitrogen-corrected metabolizable energy (AMEn), apparent ileal digestibility (AID), and apparent total tract retention (ATTR) of dry matter (DM), gross energy (GE), and nitrogen (N). All statistical analyses were performed using R version 4.3.3. Results: Results revealed significant positive effects of dietary β-mannanase supplementation on BWG (p = 0.005), FCR (p<0.001), VH (p<0.001), VH:CD (p<0.001), digesta viscosity (p<0.001), AMEn (p = 0.011), AID of GE (p = 0.002) and N (p = 0.003), and ATTR of DM (p = 0.019), GE (p = 0.002), and N (p = 0.005) in broiler chickens. In the meta-regression analysis, increasing activity levels of β-mannanase in broiler diets increased VH:CD (p< 0.001; R2 = 79.2%) and AID of N (p = 0.038; R2 = 67.4%). Conclusion: The current meta-analysis indicates that dietary β-mannanase supplementation improves energy and nutrient utilization in broiler diets possibly by decreasing digesta viscosity and enhancing intestinal morphology in broiler chickens. These beneficial effects can contribute to improved growth performance in broiler chickens.

Keywords

Acknowledgement

This work was supported by Korea Institute of Planning and Evaluation for Technology in Food, Agriculture and Forestry (IPET) through Agri-Food Export Enhancement Technology Development Program, funded by Ministry of Agriculture, Food and Rural Affairs (MAFRA; RS-2023-00233060). This research was also supported by the Chung-Ang University Graduate Research Scholarship (Academic scholarship for College of Biotechnology and Natural Resources) in 2024.

References

  1. Nguyen HT, Bedford MR, Morgan NK. Importance of considering non-starch polysaccharide content of poultry diets. Worlds Poult Sci J 2021;77:619-37. https://doi.org/10.1080/00439339.2021.1921669 
  2. Knudsen KEB. Carbohydrate and lignin contents of plant materials used in animal feeding. Anim Feed Sci Technol 1997;67:319-38. https://doi.org/10.1016/S0377-8401(97)00 009-6 
  3. Saeed M, Ayasan T, Alagawany M, El-Hack MEA, AbdelLatif MA, Patra AK. The role of β-mannanase (Hemicell) in improving poultry productivity, health and environment. Braz J Poult Sci 2019;21:eRBCA-2019-1001. https://doi.org/10.1590/1806-9061-2019-1001 
  4. Sauvant D, Letourneau-Montminy MP, Schmidely P, Boval M, Loncke C, Daniel JB. Review: Use and misuse of meta-analysis in animal science. Animal. 2020;14:s207-22. https://doi.org/10.1017/S1751731120001688 
  5. Ogbuewu IP, Modisaojang-Mojanaga MMC, Mokolopi BG, Mbajiorgu CA. A meta-analysis of responses of broiler chickens to dietary zinc supplementation: feed intake, feed conversion ratio and average daily gain. Biol Trace Elem Res 2023;201:2491-502. https://doi.org/10.1007/s12011-022-03320-5 
  6. Kiarie EG, Steelman S, Martinez M, Livingston K. Significance of single β-mannanase supplementation on performance and energy utilization in broiler chickens, laying hens, turkeys, sows, and nursery-finish pigs: a meta-analysis and systematic review. Transl Anim Sci 2021;5:txab160. https://doi.org/10.1093/tas/txab160 
  7. Poulsen K, Mathlouthi N, Bargen J. Meta-analysis on the effect of dietary β-mannanase on intestinal integrity in broiler chickens. J Appl Poult Res 2023;32:100307. https://doi.org/10.1016/j.japr.2022.100307 
  8. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med 2009;151:264-9. https://doi.org/10.7326/0003-4819-151-4-200908180-00135 
  9. Higgins JPT, Thomas J, Chandler J, et al. Cochrane handbook for systematic reviews of interventions. 2nd ed. Hoboken, NJ, USA: John Wiley & Sons; 2019. 
  10. Hedges LV. Distribution theory for glass's estimator of effect size and related estimators. J Educ Behav Stat 1981;6:107-28. https://doi.org/10.3102/10769986006002107 
  11. Higgins JPT, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med 2002;21:1539-58. https://doi.org/10.1002/sim.1186 
  12. Higgins JPT, Thomson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ 2003;327:557-60. https://doi.org/10.1136/bmj.327.7414.557 
  13. Wei C, Wang S, Wang C, Zhao Y, Zhang Y. Meta-analysis of selenium effects on the meat quality of broilers. Poult Sci 2024;103:103523. https://doi.org/10.1016/j.psj.2024.103523 
  14. Xu B, Li Z, Wang C, et al. Effects of fermented feed supplementation on pig growth performance: a meta-analysis. Anim Feed Sci Technol 2020;259:114315. https://doi.org/10.1016/j.anifeedsci.2019.114315 
  15. Zepeda-Velazquez AP, Ramirez-Perez AH, Ambriz-Vilchis V, et al. Effect of selenium supplementation on productive performance and antioxidant status of broilers under heat stress: a meta-analysis and a meta-regression. Anim Prod Sci 2020;61:208-14. https://doi.org/10.1071/AN20133 
  16. R Core Team. R: a language and environment for statistical computing. Vienna, Austria: R Foundation; c2024 [cited 2024 Feb]. Available from: https://www.r-project.org/ 
  17. Matheson NK. Mannose-based polysaccharides. Methods Plant Biochem 1990;2:371-413. https://doi.org/10.1016/B978-0-12-461012-5.50017-3 
  18. Tiwari UP, Chen H, Kim SW, Jha R. Supplemental effect of xylanase and mannanase on nutrient digestibility and gut health of nursery pigs studied using both in vivo and in vitro models. Anim Feed Sci Technol 2018;245:77-90. https://doi.org/10.1016/j.anifeedsci.2018.07.002 
  19. Lee JT, Bailey CA, Cartwright AL. β-mannanase ameliorates viscosity-associated depression of growth in broiler chickens fed guar germ and hull fractions. Poult Sci 2003;82:1925-31. https://doi.org/10.1093/ps/82.12.1925 
  20. Kiarie E, Romero LF, Nyachoti CM. The role of added feed enzymes in promoting gut health in swine and poultry. Nutr Res Rev 2013;26:71-88. https://doi.org/10.1017/S0954422413000048 
  21. Agyekum AK, Slominski BA, Nyachoti CM. Organ weight, intestinal morphology, and fasting whole-body oxygen consumption in growing pigs fed diets containing distillers dried grains with solubles alone or in combination with a multienzyme supplement. J Anim Sci 2012;90:3032-40. https://doi.org/10.2527/jas.2011-4380 
  22. Shastak Y, Ader P, Feuerstein D, Ruehle R, Matuschek M. β-mannan and mannanase in poultry nutrition. Worlds Poult Sci J 2015;71:161-74. https://doi.org/10.1017/S0043933915000136 
  23. McCleary BV, Matheson NK. Action patterns and substrate-binding requirements of β-D-mannanase with mannosaccharides and mannan-type polysaccharides. Carbohydr Res 1983;119:191-219. https://doi.org/10.1016/0008-6215(83)84056-7 
  24. Thacker SB. Meta-analysis a quantitative approach to research integration. JAMA 1988;259:1685-9. https://doi.org/10.1001/jama.1988.03720110047033 
  25. Hosseindoust A, Lee S, Nho WG, et al. A does-response study to evaluate the effects of pH-stable β-mannanase derived from Trichoderma citrinoviride on growth performance, nutrient retention, and intestine morphology in broiler chickens. Ital J Anim Sci 2019;18:147-54. https://doi.org/10.1080/1828051X.2018.1500872 
  26. Jackson ME, Geronian K, Knox A, McNab J, McCartney E. A dose-response study with feed enzyme β-mannanase in broilers provided with corn-soybean meal based diets in the absence of antibiotic growth promoters. Poult Sci 2004;83:1992-6. https://doi.org/10.1093/ps/83.12.1992 
  27. Sharifi SD, Golestani G, Yaghobfar A, Khadem A, Pashazanussi H. Effects of supplementing a multienzyme to broiler diets containing a high level of wheat or canola meal on intestinal morphology and performance of chicks. J Appl Poult Res 2013;22:671-9. https://doi.org/10.3382/japr.2011-00452 
  28. Li Y, Chen X, Chen Y, Zhimin Z, Cao Y. Effects of β-mannanase expressed by pichia pastoris in corn-soybean meal diets on broiler performance, nutrient digestibility, energy utilization and immunoglobulin levels. Anim Feed Sci Technol 2010;159:59-67. https://doi.org/10.1016/j.anifeedsci.2010.05.001 
  29. Zuo JJ, Guo AH, Yan XY, Xu M, Xia WG, Feng DY. Supplementation of β-mannanase in diet with energy adjustment on affect performance, intestinal morphology and tight junction proteins mRNA expression in broiler chickens. J Anim Vet Adv 2014;13:144-51. 
  30. Jha R, Mishra P. Dietary fiber in poultry nutrition and their effects on nutrient utilization, performance, gut health, and on the environment: a review. J Anim Sci Technol 2021;12:51. https://doi.org/10.1186/s40104-021-00576-0 
  31. Heak C, Sukon P, Kongpechr S, Tengjaroenkul B, Chuachan K. Effect of direct-fed microbials on intestinal villus height in broiler chickens: a systematic review and meta-analysis of controlled trials. Int J Poult Sci 2017;16:403-14. https://doi.org/10.3923/ijps.2017.403.414 
  32. Lv JN, Chen YQ, Guo XJ, Piao XS, Cao YH, Dong B. Effects of supplementation of β-mannanase in corn-soybean meal diets on performance and nutrient digestibility in growing pigs. Asian-Australas J Anim Sci 2013;26:579-87. https://doi.org/10.5713/ajas.2012.12612 
  33. Rothstein HR, Sutton AJ, Borenstein M. Publication bias in meta-analysis: Prevention, assessment, and adjustments. Chichester, England: John Wiley & Sons Ltd; 2005. https://doi.org/10.1002/0470870168.fmatter 
  34. Hopewell S, Loudon K, Clarke MJ, Oxman AD, Dickersin K. Publication bias in clinical trials due to statistical significance or direction of trial results. Cochrane Database Syst Rev 2009;2009:MR000006. https://doi.org/10.1002/14651858.MR000006.pub3 
  35. de Souza M, Eeckhaut V, Goossens E, et al. Guar gum as galactomannan source induces dysbiosis and reduces performance in broiler chickens and dietary β-mannanase restores the gut homeostasis. Poult Sci 2023;102:102810. https://doi.org/10.1016/j.psj.2023.102810 
  36. Jalal MAR, Zakaria HAH, Hayajneh FM, Mehyar GM. Performance, carcass characteristics, and meat quality of broiler chickens fed β-mannanase and two levels of energy. Trop Anim Sci J 2023;46:190-200. https://doi.org/10.5398/tasj.2023.46.2.190 
  37. Chuppava B, Abd El-Wahab A, Schiel B, et al. Impacts of mannanase supplementation in guar meal by-product on broiler chickens performance, foot pad health and selected organ traits: a pilot study. Eur Poult Sci 2022;86:86. https://doi.org/10.1399/eps.2022.363 
  38. Yaqoob MU, Yousaf M, Khan MI, Wang M. Effects of β-mannanase supplementation on growth performance, ileal digestibility, carcass traits, intestinal morphology, and meat quality in broilers fed low-me diets. Animals 2022;12:1126. https://doi.org/10.3390/ani12091126 
  39. Mohammadigheisar M, Shouldice VL, Balasubramanian B, Kim IH. Effect of dietary supplementation of β-mannanase on growth performance, carcass characteristics, excreta microflora, blood constituents, and nutrient ileal digestibility in broiler chickens. Anim Biosci 2021;34:1342-9. https://doi.org/10.5713/ab.20.0355 
  40. Balasubramanian B, Ingale SL, Park JH, Rathi PC, Shanmugam S, Kim IH. Inclusion of dietary β-mannanase improves performance and ileal digestibility and reduces ileal digesta viscosity of broilers fed corn-soybean meal based diet. Poult Sci 2018;97:3097-101. https://doi.org/10.3382/ps/pey157 
  41. Latham RE, Williams MP, Walters HG, Carter B, Lee JT. Efficacy of β-mannanase on broiler growth performance and energy utilization in the presence of increasing dietary galactomannan. Poult Sci 2018;97:549-56. https://doi.org/10.3382/ps/pex309 
  42. El-Masry KN, Ragaa NM, Tony MA, El-Banna RA. Effect of dietary inclusion of guar meal with or without β-mannanase supplementation on broiler performance and immunity. Pak J Nutr 2017;16:341-50. https://doi.org/10.3923/pjn.2017.341.350 
  43. Ferreira Jr HC, Hannas MI, Albino LFT, et al. Effect of addition of β-mannanase on the performance, metabolizable energy, amino acid digestibility coefficients, and immune functions of broilers fed different nutritional levels. Poult Sci 2016;95:1848-57. https://doi.org/10.3382/ps/pew076 
  44. Rehman ZU, Aziz T, Bhatti SA, et al. Effect of β-mannanase on the performance and digestibility of broilers. Asian J Anim Vet Adv 2016;11:393-8. https://doi.org/10.3923/ajava.2016.393.398 
  45. Karimi K, Zhandi M. The effect of β-mannanase and β-glucanase on small intestine morphology in male broilers fed diets containing various levels of metabolizable energy. J Appl Anim Res 2015;43:324-9. https://doi.org/10.1080/09712119.2014.978770 
  46. du Plessis RE, van Rensburg CJ. Carbohydrase and protease supplementation increased performance of broilers fed maize-soybean-based diets with restricted metabolizable energy content. S Afr J Anim Sci 2014;44:262-70. https://doi.org/10.4314/sajas.v44i3.8 
  47. Cho JH, Kim IH. Effects of beta-mannanase supplementation in combination with low and high energy dense diets for growing and finishing broilers. Livest Sci 2013;154:137-43. https://doi.org/10.1016/j.livsci.2013.03.004 
  48. Chengeni A, Torki M, Kamyab A. Effects of β-mannanasebased enzyme in corn-soy and corn-soy-canola diets on broiler performance. J Appl Anim Res 2011;39:261-8. https://doi.org/10.1080/09712119.2011.605319 
  49. Torki M. Evaluation of growth performance of broiler chicks fed with diet containing chickpea seeds supplemented with exogenous commercial enzymes. Adv Environ Biol 2011;5:595-604. 
  50. Mehri M, Adibmoradi M, Samie A, Shivazad M. Effects of β-mannanase on broiler performance, gut morphology and immune system. Afr J Biotechnol 2010;9:6221-8. 
  51. Zangiabadi H, Torki M. The effect of a β-mannanase-based enzyme on growth performance and humoral immune response of broiler chickens fed diets containing graded levels of whole dates. Trop Anim Health Prod 2010;42:1209-17. https://doi.org/10.1007/s11250-010-9550-1 
  52. Zou XT, Qiao XJ, Xu ZR. Effect of β-mannanase (Hemicell) on growth performance and immunity of broilers. Poult Sci 2006;85:2176-9. https://doi.org/10.1093/ps/85.12.2176