대한한의학회지 (The Journal of Korean Medicine)

  • 제45권2호
  • /
  • Pages.159-168
  • /
  • 2024
  • /
  • 1010-0695(pISSN)
  • /
  • 2288-3339(eISSN)
대한한의학회 (The Society of Korean Medicine)
권호 표지
DOI QR코드

DOI QR Code

약침 제제를 탑재한 마이크로니들 패치에 대한 연구 동향 분석: 문헌 검토

Analysis of research trends on microneedle patches loaded pharmacopuncture preparation: A Literature Review

  • 김민정 (상지대학교 한의과대학 침구의학과)
  • Minjeong Kim (Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Sangji University)
  • 투고 : 2024.04.23
  • 심사 : 2024.05.09
  • 발행 : 2024.06.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Objectives: The purpose of this study is to review the dissolving microneedle patches literature, which is loaded with pharmacopuncture preparation. By exploring types of pharmacopuncture preparation applied to microneedle patches, we aim to develop new potential preparation. Methods: This review included both animal and human studies that published between February 2015 and March 2024. After searching, no RCTs were found, the final selected in-vivo and in-vitro studies were analyzed. A total of 13 articles were retrieved from the international database, and a total of 5 articles were retrieved from the domestic database. Finally, 7 studies were selected, and evaluated by the published year, country of publication, types of animal model, disease type, retention type, evaluation index, adverse effects. Conclusions: According to 7 studies, pharmacopuncture preparation coated dissolving microneedle patch include bee venom, placenta, and ginseng in osteoarthritis, rheumatoid arthritis, hypertrophic scar, psoriasis, and neurodegeneration. In the future, follow-up studies on the safety, retention time, and optimal effective dose of the microneedle patches are expected.

키워드

과제정보

I thank graduate student Chang-Woo Sun for helping data extraction and organization.

참고문헌

  1. Moore LE, Vucen S, Moore AC. Trends in drug- and vaccine-based dissolvable microneedle materials and methods of fabrication. European Journal of Pharmaceutics and Biopharmaceutics. 2022;173:54-72. https://www.sciencedirect.com/science/article/pii/S0939641122000340. doi: 10.1016/j.ejpb.2022.02.013. 
  2. Wan W, Li Y, Wang J, et al. PLGA nanoparticle-based dissolving microneedle vaccine of clostridium perfringens ε toxin. Toxins. 2023;15(7):461. 
  3. Moon S, Richter-Roche M, Resch TK, et al. Microneedle patch as a new platform to effectively deliver inactivated polio vaccine and inactivated rotavirus vaccine. NPJ vaccines. 2022;7:26. 
  4. Lee I, Lin W, Shu J, Tsai S, Chen C, Tsai M. Formulation of two-layer dissolving polymeric microneedle patches for insulin transdermal delivery in diabetic mice. Journal of biomedical materials research Part A. 2017;105(1):84-93. 
  5. Demir B, Rosselle L, Voronova A, et al. Innovative transdermal delivery of insulin using gelatin methacrylate-based microneedle patches in mice and mini-pigs. Nanoscale horizons. 2022;7(2):174-184. 
  6. Liang C, Wang R, He T, et al. Revolutionizing diabetic wound healing: The power of microneedles. Chinese Journal of Plastic and Reconstructive Surgery. 2023;5(4):185-194. https://www.sciencedirect.com/science/article/pii/S2096691123000717. doi: 10.1016/j.cjprs.2023.12.004. 
  7. Huang Y, Li J, Wang Y, et al. Intradermal delivery of an angiotensin II receptor blocker using a personalized microneedle patch for treatment of hypertrophic scars. Biomaterials science. 2023;11(2):583-595. 
  8. Lee Y, Kumar S, Kim SH, et al. Odorless glutathione microneedle patches for skin whitening. Pharmaceutics. 2020;12(2):100. 
  9. Choi H, Hong J, Seo Y, et al. Self-assembled oligopeptoplex-loaded dissolving microneedles for adipocyte-targeted anti-obesity gene therapy. Adv Mater. 2024:e2309920. doi: 10.1002/adma.202309920. 
  10. Huang S, Wen T, Wang J, et al. Nanoparticle-integrated dissolving microneedles for the co-delivery of R848/aPD-1 to synergistically reverse the immunosuppressive microenvironment of triple-negative breast cancer. Acta Biomater. 2024;176:344-355. doi: 10.1016/j.actbio.2024.01.009. 
  11. Zhu T, Yu X, Yi X, et al. Lidocaine-loaded hyaluronic acid adhesive microneedle patch for oral mucosal topical anesthesia. Pharmaceutics. 2022;14(4):686. 
  12. Castilla-Casadiego D, Miranda-Muñoz KA, Roberts JL, et al. Biodegradable microneedle patch for delivery of meloxicam for managing pain in cattle. PLoS ONE. 2022;17(8):e0272169. 
  13. Zheng L, Chen Y, Gu X, et al. Co-delivery of drugs by adhesive transdermal patches equipped with dissolving microneedles for the treatment of rheumatoid arthritis. Journal of Controlled Release. 2023;365:274. doi: 10.1016/j.jconrel.2023.11.029. 
  14. Yan Q, Wang W, Weng J, et al. Dissolving microneedles for transdermal delivery of huperzine A for the treatment of alzheimer's disease. Drug Deliv. 2020;27(1):1147-1155. 
  15. Shi H, Zhou J, Wang Y, et al. A rapid corneal healing microneedle for efficient ocular drug delivery. Small. 2022;18(4):2104657. 
  16. Zhang X, Hasani-Sadrabadi MM, Zarubova J, et al. Immunomodulatory microneedle patch for periodontal tissue regeneration. Matter. 2022;5(2):666-682. doi: 10.1016/j.matt.2021.11.017. 
  17. Zhang R, Miao Q, Deng D, Wu J, Miao Y, Li Y. Research progress of advanced microneedle drug delivery system and its application in biomedicine. Colloids and Surfaces B: Biointerfaces. 2023;226:113302. https://www.sciencedirect.com/science/article/pii/S0927776523001807. doi: 10.1016/j.colsurfb.2023.113302. 
  18. Chun H, Song H. Analysis of trend of studies on microneedle treatment system (MTS). J Pharmacopuncture. 2021;24(4):182. doi: 10.3831/kpi.2021.24.4.182. 
  19. 박선주, 박지연, 우성천. 국내 한방 패치 특허 현황에 대한 분석연구. societyofpreventivekoreanmedicine. 2018;22(1):45. doi: 10.25153/spkom.2018.22.1.004. 
  20. Nguyen CD, Yoo J, An EJ, et al. Pharmacokinetic improvement provided by microneedle patch in delivering bee venom, a case study in combating scopolamine-induced neurodegeneration in mouse model. Drug Delivery. 2022;29(1):2855. doi: 10.1080/10717544.2022.2116129.
  21. Jang HM, Kim H, Park S, et al. Dissolvable microneedle patch increases the therapeutic effect of jawoongo on DNCB-induced atopic dermatitis in mice. Complement Med Res. 2023;30(1):1-10. doi: 10.1159/000525451. 
  22. Song J, Lee G, Jung M, Choi J, Park S, RCT efficacy and safety of a biodegradable hyaluronic acid microneedle patch for dry skin in atopic dermatitis : A single-blinded, split-body, randomized controlled trial. . 
  23. Huang C, Gou K, Yue X, et al. A novel hyaluronic acid-based dissolving microneedle patch loaded with ginsenoside Rg3 liposome for effectively alleviate psoriasis. Materials & Design. 2022;224. doi: 10.1016/j.matdes.2022.111363. 
  24. Du G, He P, Zhao J, et al. Polymeric microneedle-mediated transdermal delivery of melittin for rheumatoid arthritis treatment. Journal of controlled release : official journal of the Controlled Release Society. 2021;336:537-548. 
  25. Nguyen CD, Yoo J, An EJ, et al. Pharmacokinetic improvement provided by microneedle patch in delivering bee venom, a case study in combating scopolamine-induced neurodegeneration in mouse model. Drug Delivery. 2022;29(1):2855. doi: 10.1080/10717544.2022.2116129.
  26. Cheng A, Zhang S, Wang B, Gao Y. Layered dissolving microneedle containing a three-drug combination on the treatment of hypertrophic scar. Journal of Drug Delivery Science and Technology. 2024;95. doi: 10.1016/j.jddst.2024.105572. 
  27. Zheng L, Chen Y, Gu X, et al. Co-delivery of drugs by adhesive transdermal patches equipped with dissolving microneedles for the treatment of rheumatoid arthritis. J Control Release. 2024;365:274-285. doi: 10.1016/j.jconrel.2023.11.029. 
  28. Zhao M, Bai J, Lu Y, et al. Anti-arthritic effects of microneedling with bee venom gel. Journal of Traditional Chinese Medical Sciences. 2016;3(4):256. doi: 10.1016/j.jtcms.2016.09.005. 
  29. Tansathien K, Suriyaamporn P, Ngawhirunpat T, Opanasopit P, Rangsimawong W. A novel approach for skin regeneration by a potent bioactive placental-loaded microneedle patch: Comparative study of deer, goat, and porcine placentas. Pharmaceutics. 2022;14(6). doi: 10.3390/pharmaceutics14061221. 
  30. Yang L, Zhao W, Gong X, et al. Exploring potential network pharmacology-and molecular docking-based mechanism of melittin in treating rheumatoid arthritis. Medicine (Baltimore). 2023;102(32):e34728. doi: 10.1097/MD.0000000000034728. 
  31. Goo B, Lee J, Park C, Yune T, Park Y. Bee venom alleviated edema and pain in monosodium urate crystals-induced gouty arthritis in rat by inhibiting inflammation. Toxins (Basel). 2021;13(9):661. doi: 10.3390/ toxins13090661. doi: 10.3390/toxins13090661. 
  32. Park J, Jang KM, Park K. Effects of apamin on MPP(+)-induced calcium overload and neurotoxicity by targeting CaMKII/ERK/p65/STAT3 signaling pathways in dopaminergic neuronal cells. Int J Mol Sci. 2022;23(23): 15255. doi: 10.3390/ijms232315255. doi: 10.3390/ijms232315255. 
  33. Nguyen UT, Nguyen LTH, Kim B, Choi M, Yang I, Shin H. Natural compound mixture, containing emodin, genipin, chlorogenic acid, cimigenoside, and ginsenoside Rb1, ameliorates psoriasis-like skin lesions by suppressing inflammation and proliferation in keratinocytes. Evid Based Complement Alternat Med. 2020;2020:9416962. doi: 10.1155/2020/9416962. 
  34. Kwon JW, Hong SE, Kang SR, Park BY. Effect of human placental extract treatment on random-pattern skin flap survival in rats. J Invest Surg. 2019;32(4):304-313. doi: 10.1080/08941939.2017.1417518. 
  35. Li S, Cao S, Lu H, He B, Gao B. Kirigami triboelectric spider fibroin microneedle patches for comprehensive joint management. Mater Today Bio. 2024;26:101044. doi: 10.1016/j.mtbio.2024.101044. 
  36. Monou PK, Andriotis E, Tzetzis D, et al. Evaluation of 3D-printed solid microneedles coated with electrosprayed polymeric nanoparticles for simultaneous delivery of rivastigmine and N-acetyl cysteine. ACS Appl Bio Mater. 2024. doi: 10.1021/acsabm.3c00750.