The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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A Review of Herbal Medicine Treatments on Aftereffects of Thyroidectomy

갑상선 절제술 후 후유증의 한약 치료에 대한 최신 임상 연구 동향

  • Soo-duk Kim (Dept. of Internal Korean Medicine, Bu-Cheon Jaseng Hospital of Oriental Medicine) ;
  • Min-jo Seo (Dept. of Internal Korean Medicine, Bu-Cheon Jaseng Hospital of Oriental Medicine) ;
  • Su-na Park (Dept. of Internal Korean Medicine, Bu-Cheon Jaseng Hospital of Oriental Medicine) ;
  • Hye-ri Jo (Dept. of Korean Acupuncture and Moxibustion Medicine, Bu-Cheon Jaseng Hospital of Oriental Medicine) ;
  • So-hyeon Ryu (Dept. of Internal Korean Medicine, National Medical Center) ;
  • Geon-sik Kong (Dept. of Internal Korean Medicine, Bu-Cheon Jaseng Hospital of Oriental Medicine) ;
  • Yo-sup Choi (Dept. of Internal Korean Medicine, Bu-Cheon Jaseng Hospital of Oriental Medicine)
  • 김수덕 (부천자생한방병원 한방내과) ;
  • 서민조 (부천자생한방병원 한방내과) ;
  • 박수나 (부천자생한방병원 한방내과) ;
  • 조혜리 (부천자생한방병원 침구과) ;
  • 류소현 (국립중앙의료원 한방내과) ;
  • 공건식 (부천자생한방병원 한방내과) ;
  • 최요섭 (부천자생한방병원 한방내과)
  • Received : 2024.08.21
  • Accepted : 2024.10.04
  • Published : 2024.09.30
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Abstract

Objectives: This study summarizes the current trends and results in clinical studies on herbal medicine treatments after thyroidectomy. Methods: Studies published between 2019 and 2024 were searched for on the China National Knowledge Infrastructure (CNKI), PubMed, and Research Information Sharing Service (RISS). The studies were analyzed according to year, study design, characteristics of the patients, and traditional Chinese medicine (TCM) intervention. A meta-analysis was conducted and classified according to the outcome measurements, such as the total effective rate (TER), thyroid stimulating hormone (TSH), free T4 (FT4), self-rating depression scale (SDS), CD3+, CD4+, and CD8+. CD8+. Results: A total of 18 randomized controlled trials (RCTs) and 5 non-randomized controlled trials were reviewed. The most common herbal prescriptions were decoctions made from Yangyin Sanjie (Yangeumsangyeol-tang), Yiqi Sanjie (Ikgisangyeol-tang), Yiqi Yangyin Sanjie (Ikgiyangeumsangyeol-tang), Yiqi Yangyin (Ikgiyangeum-tang), and Huiyan Zhuyu (Hoeyeomchugeo-tang). The most frequently used herbs were Prunellae Spica, Scrophulariae Radix, and Astragali Radix. The meta-analysis found that the group using both herbal and Western medicine was benefited more than the group using Western medicine alone (RR: 1.28, 95% CI: 1.20-1.37, P<0.00001). The experimental group had higher TSH, CD3+, and CD4+ levels, while FT4, SDS, and CD8++ were lower. However, due to high study heterogeneity, the results were not statistically significant. Conclusion: Complications after thyroidectomy include hypothyroidism, hypoparathyroidism, and psychological aftereffects. Herbal and conventional treatments showed potential in improving hormone levels, immune function, and depression, but statistical significance was limited due to study variability. These results should be interpreted cautiously given the risk of bias in the trials.

Keywords

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