Journal of Dental Anesthesia and Pain Medicine

  • 제24권5호
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  • Pages.351-360
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  • 2024
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  • 2383-9309(pISSN)
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  • 2383-9317(eISSN)
대한치과마취과학회 (The Korean Dental Society of Anesthsiology)
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Assessment of the effect of premedication on the success of inferior alveolar nerve block in tobacco chewing patients with symptomatic irreversible pulpitis: a randomized control trial

  • 투고 : 2024.06.02
  • 심사 : 2024.08.06
  • 발행 : 2024.10.01
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초록

Background: This study aimed to evaluate and compare the efficacy of oral premedication with ibuprofen on the anesthetic efficacy of inferior alveolar nerve block (IANB) using 2% lignocaine and 1:100000 epinephrine in tobacco-chewing (TC) and non-tobacco-chewing (NTC) patients with symptomatic irreversible pulpitis (SIP) during nonsurgical endodontic intervention (NEI). Methods: This multicenter, prospective, double-blind, two-arm parallel-group randomized controlled trial involving 160 patients was conducted for a period of 9 months. The patients were classified into the study (TC patients) and control (NTC patients) groups, which were subdivided into two subgroups 1 hour before the procedure based on oral premedication with tab ibuprofen 600 mg. Nicotine dependence was assessed using the Modified Fagerstrom Tolerance Nicotine Scale. Patients were administered an IANB injection of 2% lignocaine containing epinephrine 1:100000 after premedication. Pulpal anesthesia before NEI was confirmed using electric pulp testing and cold spraying. Patients rated their pain on the 10-point visual analog scale (VAS) during NEI thrice at the dentin, pulp, and instrumentation levels. No pain at each level indicated the success of anesthesia. Results: The success and failure rates did not differ between the premedication and non-premedication subgroups in the TC or NTC groups (P > 0.05). However, the success rate was higher in the premedication subgroup of the NTC group (52.5%) than in the TC group (45%). Most patients with premedication experienced failure at the instrumentation level, whereas patients in the non-premedication group experienced pain at the dentin level. Failure rates of IANB did not differ significantly at different levels between the groups (P > 0.05). The mean VAS scores differed significantly at the dentin level in both groups, with lower values in the premedication group (P < 0.05). Conclusions: The efficacy of ibuprofen premedication with IANB during NEI did not differ significantly between the TC and NTC patients with SIP. The effect of premedication was more significant in the NTC group than in the TC group. A causal relationship between nicotine consumption and the success of premedication could not be established, and further studies are required to validate the results of the present study.

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과제정보

We thank all study participants for their active contributions to the present study. We are also grateful to the statisticians for their kind support and assistance in the data analysis. We affirm that we have no financial affiliation (e.g., employment, direct payment, stock holdings, retainers, consultantships, patent licensing arrangements, or honoraria) or involvement with any commercial organization with direct financial interest in the subject or materials discussed in this manuscript, nor have any such arrangements existed in the past three years.

참고문헌

  1. Aggarwal V, Singla M, Subbiya A, Vivekanandhan P, Sharma V, Sharma R, et al. Effect of preoperative pain on inferior alveolar nerve block. Anesth Prog 2015; 62: 135-9.  https://doi.org/10.2344/15-00019.1
  2. Becker DE, Reed KL. Essentials of local anesthetic pharmacology. Anesth Prog 2006; 53: 98-108; quiz 109-10.  https://doi.org/10.2344/0003-3006(2006)53[98:EOLAP]2.0.CO;2
  3. Benowitz NL. Pharmacology of nicotine: addiction, smoking-induced disease, and therapeutics. Annu Rev Pharmacol Toxicol 2009; 49: 57-71.  https://doi.org/10.1146/annurev.pharmtox.48.113006.094742
  4. Fowler S, Drum M, Reader A, Beck M. Anesthetic success of an inferior alveolar nerve block and supplemental articaine buccal infiltration for molars and premolars in patients with symptomatic irreversible pulpitis. J Endod 2016; 42: 390-2.  https://doi.org/10.1016/j.joen.2015.12.025
  5. Rood JP, Pateromichelakis S. Inflammation and peripheral nerve sensitisation. Br J Oral Surg 1981; 19: 67-72.  https://doi.org/10.1016/0007-117X(81)90023-8
  6. Nagendrababu V, Pulikkotil SJ, Veettil SK, Teerawattanapong N, Setzer FC. Effect of nonsteroidal anti-inflammatory drug as an oral premedication on the anesthetic success of inferior alveolar nerve block in treatment of irreversible pulpitis: a systematic review with meta-analysis and trial sequential analysis. J Endod 2018; 44: 914-22. e2.  https://doi.org/10.1016/j.joen.2018.02.017
  7. Noguera-Gonzalez D, Cerda-Cristerna BI, Chavarria-Bolanos D, Flores-Reyes H, Pozos-Guillen A. Efficacy of preoperative ibuprofen on the success of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a randomized clinical trial. Int Endod J 2013; 46: 1056-62.  https://doi.org/10.1111/iej.12099
  8. Modaresi J, Dianat O, Mozayeni MA. The efficacy comparison of ibuprofen, acetaminophen-codeine, and placebo premedication therapy on the depth of anesthesia during treatment of inflamed teeth. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006; 102: 399-403.  https://doi.org/10.1016/j.tripleo.2005.10.053
  9. Parirokh M, Ashouri R, Rekabi AR, Nakhaee N, Pardakhti A, Askarifard S, et al. The effect of premedication with ibuprofen and indomethacin on the success of inferior alveolar nerve block for teeth with irreversible pulpitis. J Endod 2010; 36: 1450-4.  https://doi.org/10.1016/j.joen.2010.05.007
  10. Global adult tobacco survey second round india 2016-2017 report. available from http://download.tiss.edu/Global_Adult_Tobacco_Survey2_India_2016-17_June2018.pdf 
  11. Sayhan H, Beyaz SG, Celiktas A. The local anesthetic and pain relief activity of alkaloids [Internet]. Alkaloids - Alternatives in Synthesis, Modification and Application. InTech; 2017. Available from http://dx.doi.org/10.5772/intechopen.69847 
  12. Ho YC, Chang YC. Regulation of nicotine-induced cyclooxygenase-2 protein expression in human gingival fibroblasts. Acta Pharmacol Sin 2006; 27: 409-13.  https://doi.org/10.1111/j.1745-7254.2006.00286.x
  13. Zhou Y, Wang ZX, Tang MP, Yao CJ, Xu WJ, Wang LY, et al. Nicotine induces cyclooxygenase-2 and prostaglandin E(2) expression in human umbilical vein endothelial cells. Int Immunopharmacol 2010; 10: 461-6.  https://doi.org/10.1016/j.intimp.2009.12.019
  14. Al-Noori NM, Ibraheem NS, Abdulmunem MM. The impact of cigarette smoking on the efficiency of local anesthesia during simple tooth extraction. Saudi Dent J 2021; 33: 674-8.  https://doi.org/10.1016/j.sdentj.2020.04.011
  15. Ebbert JO, Patten CA, Schroeder DR. The fagerstrom test for nicotine dependence-smokeless tobacco (FTND-ST). Addict Behav 2006; 31: 1716-21.  https://doi.org/10.1016/j.addbeh.2005.12.015
  16. Hegde V, Shanmugasundaram S, Shaikh S, Kulkarni V, Suresh N, Setzer FC, et al. Effect of preoperative oral steroids in comparison to anti-inflammatory on anesthetic success of inferior alveolar nerve block in mandibular molars with symptomatic irreversible pulpitis-a double-blinded randomized clinical trial. J Endod 2023; 49: 354-61.  https://doi.org/10.1016/j.joen.2023.01.007
  17. Kennedy S, Reader A, Nusstein J, Beck M, Weaver J. The significance of needle deflection in success of the inferior alveolar nerve block in patients with irreversible pulpitis. J Endod 2003; 29: 630-3.  https://doi.org/10.1097/00004770-200310000-00004
  18. Nusstein J, Reader A, Nist R, Beck M, Meyers WJ. Anesthetic efficacy of the supplemental intraosseous injection of 2% lidocaine with 1:100,000 epinephrine in irreversible pulpitis. J Endod 1998; 24: 487-91.  https://doi.org/10.1016/S0099-2399(98)80053-8
  19. Reisman D, Reader A, Nist R, Beck M, Weaver J. Anesthetic efficacy of the supplemental intraosseous injection of 3% mepivacaine in irreversible pulpitis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997; 84: 676-82. https://doi.org/10.1016/s1079-2104(97)90372-3. 
  20. Lindemann M, Reader A, Nusstein J, Drum M, Beck M. Effect of sublingual triazolam on inferior alveolar nerve block success in patients with irreversible pulpitis. J Endod 2008; 34: 1167-70.  https://doi.org/10.1016/j.joen.2008.07.013
  21. So GB, Silva IA, Weissheimer T, Lenzi TL, So MVR, da Rosa RA. Do NSAIDs used prior to standard inferior alveolar nerve blocks improve the analgesia of mandibular molars with irreversible pulpitis? An umbrella review. Clin Oral Investig 2023; 27: 1885-97.  https://doi.org/10.1007/s00784-023-04979-3
  22. Khademi A, Iranmanesh P, Mosayebi N, Heydari M, BagheriehS. Effect of premedication on the success of inferior alveolar nerve block in patients diagnosed with irreversible pulpitis: an umbrella review. Dent Res J 2023; 20: 75. 
  23. Bidar M, Mortazavi S, Forghani M, Akhlaghi S. Comparison of effect of oral premedication with ibuprofen or dexamethasone on anesthetic efficacy of inferior alveolar nerve block in patients with irreversible pulpitis: a prospective, randomized, controlled, double-blind study. Bull Tokyo Dent Coll 2017; 58: 231-6.  https://doi.org/10.2209/tdcpublication.2016-0050
  24. Elnaghy AM, Elshazli AH, Elsaka SE. Effectiveness of oral premedication of meloxicam, ketorolac, dexamethasone, and ibuprofen on the success rate of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a prospective, double-blind, randomized controlled trial. Quintessence Int 2023; 10; 54: 92-9. 
  25. Kumar M, Singla R, Gill GS, Kalra T, Jain N. Evaluating combined effect of oral premedication with ibuprofen and dexamethasone on success of inferior alveolar nerve block in mandibular molars with symptomatic irreversible pulpitis: a prospective, double-blind, randomized clinical trial. J Endod 2021; 47: 705-10.  https://doi.org/10.1016/j.joen.2021.01.005
  26. Aggarwal V, Singla M, Kabi D. Comparative evaluation of effect of preoperative oral medication of ibuprofen and ketorolac on anesthetic efficacy of inferior alveolar nerve block with lidocaine in patients with irreversible pulpitis: a prospective, double-blind, randomized clinical trial. J Endod 2010; 36: 375-8.  https://doi.org/10.1016/j.joen.2009.11.010
  27. Oleson M, Drum M, Reader A, Nusstein J, Beck M. Effect of preoperative ibuprofen on the success of the inferior alveolar nerve block in patients with irreversible pulpitis. J Endod 2010; 36: 379-82.  https://doi.org/10.1016/j.joen.2009.12.030
  28. Gould HJ 3rd, England JD, Soignier RD, Nolan P, Minor LD, Liu ZP, et al. Ibuprofen blocks changes in Na v 1.7 and 1.8 sodium channels associated with complete Freund's adjuvant-induced inflammation in the rat. J Pain 2004; 5: 270-80.  https://doi.org/10.1016/j.jpain.2004.04.005
  29. Prasanna N, Subbarao CV, Gutmann JL. The efficacy of pre-operative oral medication of lornoxicam and diclofenac potassium on the success of inferior alveolar nerve block in patients with irreversible pulpitis: a double-blind, randomised controlled clinical trial. Int Endod J 2011; 44: 330-6.  https://doi.org/10.1111/j.1365-2591.2010.01833.x
  30. Miller LG. Recent developments in the study of the effects of cigarette smoking on clinical pharmacokinetics and clinical pharmacodynamics. Clin Pharmacokinet 1989; 17: 90-108.  https://doi.org/10.2165/00003088-198917020-00003
  31. Corbella S, Taschieri S, Mannocci F, Rosen E, Tsesis I, Del Fabbro M. Inferior alveolar nerve block for the treatment of teeth presenting with irreversible pulpitis: a systematic review of the literature and meta-analysis. Quintessence Int 2017; 48: 69-82. 
  32. Lapidus D, Goldberg J, Hobbs EH, Ram S, Clark GT, Enciso R. Effect of premedication to provide analgesia as a supplement to inferior alveolar nerve block in patients with irreversible pulpitis. J Am Dent Assoc 2016; 147: 427-37.  https://doi.org/10.1016/j.adaj.2016.01.006
  33. Li C, Yang X, Ma X, Li L, Shi Z. Preoperative oral nonsteroidal anti-inflammatory drugs for the success of the inferior alveolar nerve block in irreversible pulpitis treatment: a systematic review and meta-analysis based on randomized controlled trials. Quintessence Int 2012; 43: 209-19. 
  34. Shirvani A, Shamszadeh S, Eghbal MJ, Marvasti LA, AsgaryS. Effect of preoperative oral analgesics on pulpal anesthesia in patients with irreversible pulpitis-a systematic review and meta-analysis. Clin Oral Investig 2017; 21: 43-52.  https://doi.org/10.1007/s00784-016-1974-1
  35. Tupyota P, Chailertvanitkul P, Laopaiboon M, Ngamjarus C, Abbott PV, Krisanaprakornkit S. Supplementary techniques for pain control during root canal treatment of lower posterior teeth with irreversible pulpitis: a systematic review and meta-analysis. Aust Endod J 2018; 44: 14-25.