Journal of the Society of Cosmetic Scientists of Korea (대한화장품학회지)

Society of Cosmetic Scientists of Korea (대한화장품학회)
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Study on the Efficacies of Anti-acne Cosmetic Containing Lactonic Hydroxy Acid for Improving Acne Skin Care

락톤형 하이드록시애씨드를 적용한 여드름 피부 개선 화장품 효능 연구

  • Moonki Baek (Department of Cosmetology, Ajou University) ;
  • Bum-Ho Bin (Department of Biological Science, Ajou University)
  • Received : 2024.08.08
  • Accepted : 2024.09.30
  • Published : 2024.09.30
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Abstract

This study investigates the efficacy of anti-acne cosmetics containing lactonic hydroxy acid, specifically gluconodeltalactone (GDL), in improving acne skin treatment. In sebaceous cells induced by linoleic acid, GDL at concentrations of 1.0 mg/mL or higher demonstrated a concentration-dependent inhibition of lipid synthesis. Antibacterial activity of GDL against Cutibacterium acnes (C. acnes) was confirmed through minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) assays. Based on these in vitro results, a clinical test was conducted involving 65 participants to evaluate the effects of a anti-acne cosmetic formulation containing 3% GDL over an eight-week period. The results indicated a statistically significant improvement (p < 0.05) in both inflammatory acne lesions (papules, pustules, and nodules) and non-inflammatory lesions (comedones) from as early as two weeks of application, without any reported skin irritation. The results confirm that cosmetics with GDL can be used effectively and safely without long-term skin irritation, even for consumers with sensitive acne-prone skin.

본 연구는 락톤형 하이드록시애씨드인 글루코노델타락톤(GDL)을 적용한 화장품의 여드름 피부 개선 효과에 관한 내용으로써, 리놀레익애씨드로 유도된 피지 세포에서 GDL 투입하여 지질 합성 억제 효능을 확인한 결과, 1.0 mg/mL 이상에서 농도 의존적으로 효능을 나타내는 것으로 확인하였으며, 최소 저해 농도(MIC)와 최소 사멸 농도(MBC) 측정하여 GDL이 여드름균(C. acnes)에 대한 항균효과를 가지고 있음을 확인하였다. 해당 결과를 바탕으로 총 65 명을 대상으로 GDL 3% 함유된 화장품에 대한 여드름 피부 인체 적용 시험을 8 주간 실시한 결과, 사용 2 주 후부터 구진, 농포, 결절 등의 염증성 여드름 병변뿐 아니라 면포와 같은 비염증성 병변에 모두에 피부 자극없이 통계적으로 유의한 수준(p < 0.05)의 효능을 갖는 것으로 확인되었다. 이 결과를 통해 GDL을 적용한 화장품은 민감한 타입의 여드름성 피부 소비자에게도 장기간 피부 자극없이 효과적이고 안전하게 사용할 수 있는 제품임을 확인 할 수 있었다.

Keywords

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