DOI QR코드

DOI QR Code

Relationship between Household Air Quality and Hearing Loss in Korean Adults: Analysis of Data from The Korea National Health and Nutrition Examination Survey 2020~2021

우리나라 성인에서 가정 실내공기질과 난청 사이의 관계: 국민건강영양조사 2020~2021

  • Sang Shin PYO (Department of Biomedical Laboratory Science, Shinhan University)
  • Received : 2024.06.25
  • Accepted : 2024.07.26
  • Published : 2024.09.30

Abstract

The purpose of this study was to identify the household air pollutants most significantly impacting hearing loss, using data from the 8th Korea National Health and Nutrition Examination Survey. Of the 1,980 participants, those with missing data were excluded from the study population, resulting in the final inclusion of 298 participants. Mild hearing loss is defined as a unilateral or bilateral pure-tone threshold average (PTA) of 26~40 dB, and moderate hearing loss is defined as a unilateral or bilateral PTA of 41 dB or higher. The mean of the PTAs for both ears is defined as the sum of the PTAs of the left and the right ears divided by 2. Complex samples multiple logistic regression analysis revealed that formaldehyde exposure independently significantly increased the risk of moderate hearing loss (odds ratio=1.050, P<0.001). Additionally, in the complex samples general linear model, toluene exposure (B=0.026, P<0.001) was found to be independently significantly associated with an increase in the mean of PTAs for both ears, where a higher mean of the PTAs for both ears indicates a decrease in hearing ability. These results suggest a strong association between hearing loss and the presence of toluene or formaldehyde in indoor air.

이 연구의 목적은 제8기 국민건강영양조사 자료를 사용하여 가정 내 공기 오염물질 중 난청에 가장 영향을 미치는 물질을 찾는 것이었다. 총 1,980명의 참가자 중, 결측치가 있는 참가자들은 연구 대상에서 제외되었으며, 최종적으로 298명의 참가자가 분석에 포함되었다. 경도 난청은 한쪽 귀 또는 양쪽 귀의 순음역치평균이 26 dB 이상 41 dB 미만인 경우로 정의하였고, 중등도 난청은 한쪽 귀 또는 양쪽 귀의 순음역치평균이 41 dB 이상인 경우로 정의하였다. 양측 순음역치평균의 평균은 왼쪽 귀와 오른쪽 귀의 순음역치평균을 합한 후 2로 나눈 값으로 정의하였다. 복합표본 다중 로지스틱 회귀분석의 결과, 폼알데하이드 노출은 중등도 난청의 위험도를 높이는 데 독립적으로 유의하였다(OR=1.050, P<0.001). 또한, 복합표본 일반선형모델 분석에서 톨루엔(B=0.026, P<0.001)의 노출은 양측 순음역치평균의 평균을 높이는 데 독립적으로 유의한 연관이 있었으며, 이는 양측 순음역치평균의 평균이 높을수록 청력의 감소를 의미한다. 이러한 결과는 난청과 실내 공기 중 톨루엔 및 폼알데하이드의 존재 사이에 강한 연관성이 있음을 암시한다.

Keywords

References

  1. Goman AM, Lin FR. Hearing loss in older adults - from epidemiological insights to national initiatives. Hear Res. 2018;369:29-32. https://doi.org/10.1016/j.heares.2018.03.031
  2. Cunningham LL, Tucci DL. Hearing loss in adults. N Engl J Med. 2017;377:2465-2473. https://doi.org/10.1056/nejmra1616601
  3. Baiduc RR, Sun JW, Berry CM, Anderson M, Vance EA. Relationship of cardiovascular disease risk and hearing loss in a clinical population. Sci Rep. 2023;13:1642. https://doi.org/10.1038/s41598-023-28599-9
  4. Choi Y, Go J, Chung JW. Association between hearing level and mental health and quality of life in adults aged >40 years. J Audiol Otol. 2024;28:52-58. https://doi.org/10.7874/jao.2023.00213
  5. Thomson RS, Auduong P, Miller AT, Gurgel RK. Hearing loss as a risk factor for dementia: a systematic review. Laryngoscope Investig Otolaryngol. 2017;2:69-79. https://doi.org/10.1002/lio2.65
  6. Kim S, Park JM, Han JS, Seo JH, Han KD, Joo YH, et al. Age-related hearing loss in the Korea National Health and Nutrition Examination Survey. PLoS One. 2020;15:e0243001. https://doi.org/10.1371/journal.pone.0243001
  7. Brown CS, Emmett SD, Robler SK, Tucci DL. Global hearing loss prevention. Otolaryngol Clin North Am. 2018;51:575-592. https://doi.org/10.1016/j.otc.2018.01.006
  8. Walker JJ, Cleveland LM, Davis JL, Seales JS. Audiometry screening and interpretation. Am Fam Physician. 2013;87:41-47.
  9. Musiek FE, Shinn J, Chermak GD, Bamiou DE. Perspectives on the pure-tone audiogram. J Am Acad Audiol. 2017;28:655-671. https://doi.org/10.3766/jaaa.16061
  10. Maung TZ, Bishop JE, Holt E, Turner AM, Pfrang C. Indoor air pollution and the health of vulnerable groups: a systematic review focused on particulate matter (PM), volatile organic compounds (VOCs) and their effects on children and people with pre-existing lung disease. Int J Environ Res Public Health. 2022;19:8752. https://doi.org/10.3390/ijerph19148752
  11. Hamra GB, Guha N, Cohen A, Laden F, Raaschou-Nielsen O, Samet JM, et al. Outdoor particulate matter exposure and lung cancer: a systematic review and meta-analysis. Environ Health Perspect. 2014;122:906-911. https://doi.org/10.1289/ehp/1408092
  12. Janfaza S, Khorsand B, Nikkhah M, Zahiri J. Digging deeper into volatile organic compounds associated with cancer. Biol Methods Protoc. 2019;4:bpz014. https://doi.org/10.1093/biomethods/bpz014
  13. Mai JL, Yang WW, Zeng Y, Guan YF, Chen SJ. Volatile organic compounds (VOCs) in residential indoor air during interior finish period: Sources, variations, and health risks. Hyg Environ Health Adv. 2024;9:100087. https://doi.org/10.1016/j.heha.2023.100087
  14. Tsai SC, Hsu YC, Lai JN, Chou RH, Fan HC, Lin FC, et al. Long-term exposure to air pollution and the risk of developing sudden sensorineural hearing loss. J Transl Med. 2021;19:424. https://doi.org/10.1186/s12967-021-03095-8
  15. Ju MJ, Park SK, Kim SY, Choi YH. Long-term exposure to ambient air pollutants and hearing loss in Korean adults. Sci Total Environ. 2022;820:153124. https://doi.org/10.1016/j.scitotenv.2022.153124
  16. Smielowska M, Marc M, Zabiegala B. Indoor air quality in public utility environments-a review. Environ Sci Pollut Res Int. 2017;24:11166-11176. https://doi.org/10.1007/s11356-017-8567-7
  17. Johnson CE, Danhauer JL, Ellis BB, Jilla AM. hearing aid benefit in patients with mild sensorineural hearing loss: a systematic review. J Am Acad Audiol. 2016;27:293-310. https://doi.org/10.3766/jaaa.14076
  18. Oh K, Kim Y, Kweon S, Kim S, Yun S, Park S, et al. Korea National Health and Nutrition Examination Survey, 20th anniversary: accomplishments and future directions. Epidemiol Health. 2021;43:e2021025. https://doi.org/10.4178/epih.e2021025
  19. Filley CM, Halliday W, Kleinschmidt-DeMasters BK. The effects of toluene on the central nervous system. J Neuropathol Exp Neurol. 2004;63:1-12. https://doi.org/10.1093/jnen/63.1.1
  20. Win-Shwe TT, Fujimaki H. Neurotoxicity of toluene. Toxicol Lett. 2010;198:93-99. https://doi.org/10.1016/j.toxlet.2010.06.022
  21. Zhang Y, Liu Y, Li Z, Liu X, Chen Q, Qin J, et al. Effects of coexposure to noise and mixture of toluene, ethylbenzene, xylene, and styrene (TEXS) on hearing loss in petrochemical workers of southern China. Environ Sci Pollut Res Int. 2023;30:31620-31630. https://doi.org/10.1007/s11356-022-24414-6
  22. Staudt AM, Whitworth KW, Chien LC, Whitehead LW, Gimeno Ruiz de Porras D. Association of organic solvents and occupational noise on hearing loss and tinnitus among adults in the U.S., 1999-2004. Int Arch Occup Environ Health. 2019;92:403-413. https://doi.org/10.1007/s00420-019-01419-2
  23. Hemmativaghef E. Exposure to lead, mercury, styrene, and toluene and hearing impairment: evaluation of dose-response relationships, regulations, and controls. J Occup Environ Hyg. 2020;17:574-597. https://doi.org/10.1080/15459624.2020.1842428
  24. Sakamoto T, Miyake M. [Health effects of formaldehyde, as an indoor air pollutant]. Kaibogaku Zasshi. 2010;85:35-41. Japanese.
  25. Tulpule K, Dringen R. Formaldehyde in brain: an overlooked player in neurodegeneration? J Neurochem. 2013;127:7-21. https://doi.org/10.1111/jnc.12356
  26. Kim SH, Choi JW, Suh MW, Lee JH, Oh SH, Song JJ, et al. Effect of formaldehyde on human middle ear epithelial cells. Biomed Res Int. 2018;2018:6387983. https://doi.org/10.1155/2018/6387983
  27. Jafari MJ, Dehghani A, Khavanin A, Azari-Reza-Zade M, Dadashpourahangar A. The impact of noise and formaldehyde exposure on oxidative stress indices in blood and liver tissue of rat. Int J Occup Hyg. 2015;6:61-67.
  28. Kim J, Shim IK, Won SR, Hwang ES, Lee Y, Park S, et al. Indoor air quality and its determinants in underground shopping malls in Korea. Environ Int. 2024;183:108395. https://doi.org/10.1016/j.envint.2023.108395
  29. Pegas PN, Alves CA, Evtyugina MG, Nunes T, Cerqueira M, Franchi M, et al. Indoor air quality in elementary schools of Lisbon in spring. Environ Geochem Health. 2011;33:455-468. https://doi.org/10.1007/s10653-010-9345-3
  30. Yun Y, Lee SY. Updates on genetic hearing loss: from diagnosis to targeted therapies. J Audiol Otol. 2024;28:88-92. https://doi.org/10.7874/jao.2024.00157