Korean Journal of Veterinary Service (한국동물위생학회지)

The Korean Society of Veterinary Service (한국동물위생학회)
권호 표지
DOI QR코드

DOI QR Code

Concurrent primary malignant tumors in mammary gland and uterus with pyometra and inguinal hernia

  • Seung-Hyun Kim (Department of Veterinary Surgery, College of Veterinary Medicine, Chonnam National University) ;
  • Jun-Gyu Park (Department of Veterinary Zoonotic Diseases, College of Veterinary Medicine, Chonnam National University) ;
  • Seong-Soo Kang (Department of Veterinary Surgery, College of Veterinary Medicine, Chonnam National University) ;
  • Se-Eun Kim (Department of Veterinary Surgery, College of Veterinary Medicine, Chonnam National University) ;
  • Kwangsik Jang (Department of Veterinary Surgery, College of Veterinary Medicine, Chonnam National University) ;
  • Bock-Gie Jung (Department of Veterinary Microbiology, College of Veterinary Medicine, Chonnam National University) ;
  • Sang-Ik Park (Department of Veterinary Pathology, College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University) ;
  • Chun-Sik Bae (Department of Veterinary Surgery, College of Veterinary Medicine, Chonnam National University)
  • Received : 2024.08.29
  • Accepted : 2024.09.09
  • Published : 2024.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

In this case study, we present a rare occurrence of simultaneous primary malignant neoplasms arising from the mammary gland and uterus in conjunction with pyometra and inguinal hernia. The subject, a 16-year-old intact mixed-breed dog, exhibited tubulopapillary carcinoma of the mammary gland with grade II malignancy and uterine leiomyosarcoma. Treatment involved partial mastectomy for the mammary carcinoma and ovariohysterectomy for the uterine leiomyosarcoma. Moreover, the inguinal hernia was concurrently repaired during the tumorectomies. The patient demonstrated positive postoperative progress over a span of two years, emphasizing the effectiveness of surgical intervention in managing the coinciding pathologies in an elderly canine. This unique co-occurrence of primary malignant neoplasms originating from distinct organ systems presents valuable insights into diagnostic approaches, disease characteristics, and surgical interventions in the realm of clinical oncology.

Keywords

Acknowledgement

This report was supported by "Regional Innovation Strategy (RIS)" through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (MOE) (2021RIS-002) and Chonnam National University (Grant number: 2023-0874).

References

  1. Agostinho JM, de Souza A, Schocken-Iturrino RP, Beraldo LG, Borges CA, Avila FA, Marin J M. 2014. Escherichia coli strains isolated from the uteri horn, mouth, and rectum of bitches duffering from pyometra: virulence factors, antimicrobial susceptibilities, and slonal relationships among strains. Int J Microbiol 2014: 979584.
  2. Castillo JM, Dockweiler JC, Cheong SH, de Amorim MD. 2018. Pyometra and unilateral uterine horn torsion in a sheep. Reprod Domest Anim 53(1): 274-277.
  3. Cohen M, Post GS, Wright JC. 2003. Gastrointestinal leiomyosarcoma in 14 dogs. J Vet Intern Med 17(1): 107-110.
  4. Fieni F, Topie E, Gogny A. 2014. Medical treatment for pyometra in dogs. Reprod Domest Anim 49 (Suppl 2): 28-32.
  5. Gilbertson SR, Kurzman ID, Zachrau RE, Hurvitz AI, Black MM. 1983. Canine mammary epithelial neoplasms: biologic implications of morphologic characteristics assessed in 232 dogs. Vet Pathol 20(2): 127-142.
  6. Goldschmidt M, Pena L, Rasotto R, Zappulli V. 2011. Classification and grading of canine mammary tumors. Vet Pathol 48(1): 117-131.
  7. Hagman R. 2018. Pyometra in small animals. Vet Clin North Am Small Anim Pract 48(4): 639-661.
  8. Hagman R. 2022. Pyometra in small animals 2.0. Vet Clin North Am Small Anim Pract 52(3): 631-657.
  9. Jitpean S, Strom-Holst B, Emanuelson U, Hoglund OV, Pettersson A, Alneryd-Bull C, Hagman R. 2014. Outcome of pyometra in female dogs and predictors of peritonitis and prolonged postoperative hospitalization in surgically treated cases. BMC Vet Res 10: 6.
  10. KasseFN, Fairbrother JM, Dubuc J. 2016. Relationship between virulence factors and postpartum metritis in dairy cows. J Dairy Sci 99(6): 4656-4667.
  11. Kazmierczak J, Sugai NJ, Withowski KE, Jonatan A, LeRoith T, Cecere JT. 2023. Case report: A case of oviductal and uterine leiomyosarcoma in an 11-year-old dog. Front Vet Sci 10: 1227799.
  12. Pena FJ, Gines JA, Duque J, Vieitez V, Martinez-Perez R, Madejon L, Nunez Martinez I, Moran JM, Fernandez-Garcia S. 2006. Endometrial adenocarcinoma and mucometra in a 6-year-old Alaska Malamute dog. Reprod Domest Anim 41(2): 189-190.
  13. Percival A, Singh A, Zur Linden RA, Watrous G, Patten S, Valverde A, Ratsep E. 2018. Massive uterine lipoleiomyoma and leiomyoma in a miniature poodle bitch. Can Vet J 59(8): 845-850.
  14. Rainey B, Singh A, Valverde A, Hoddinott K, Beaufrere H, Tindal L, Smith D. 2018. Laparoscopic-assisted ovariohysterectomy for the treatment of pyometra in a Bengal tiger (Panthera tigris tigris ). Can Vet J 59(8): 895-898.
  15. Rasotto R, Berlato D, Goldschmidt MH, Zappulli V. 2017. Prognostic significance of canine mammary tumor histologic subtypes: An observational cohort study of 229 cases. Vet Pathol 54(4):571-578.
  16. Rybicka A, Krol M. 2016. Identification and characterization of cancer stem cells in canine mammary tumors. Acta Vet Scand 58(1): 86.
  17. Tsioli VG, Gouletsou PG, Loukopoulos P, Zavlaris M, Galatos AD. 2011. Uterine leiomyosarcoma and pyometra in a dog. J Small Anim Pract 52(2): 121-124.
  18. Waters DJ, Roy RG, Stone EA. 1993. A retrospective study of inguinal hernia in 35 dogs. Vet Surg 22(1): 44-49.
  19. Xavier RGC, Santana CH, de Castro YG, de Souza TGV, do Amarante VS, Santos RL, Silva ROS. 2023. Canine pyometra: A short review of current advances. Animals 13(21): 3310.