Korean Journal of Veterinary Service (한국동물위생학회지)

The Korean Society of Veterinary Service (한국동물위생학회)
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Comparative analysis of the safety of liquid and powder propolis in beagle dogs through blood tests

액상과 고상의 프로폴리스를 투여한 비글견의 혈액 검사를 통한 안전성 비교 분석

  • Hyejean Cho (Division of Emerging Virus & Vector Research, Korea National Institute of Health, Korea Disease Control and Prevention Agency)
  • 조혜진 (질병관리청 국립보건연구원 신종바이러스매개체연구과)
  • Received : 2024.09.19
  • Accepted : 2024.09.20
  • Published : 2024.09.30
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Abstract

The aim of this study was to assess and compare the toxicity and safety of two types of propolis (liquid and powder) in beagle dogs. Blood counts, serum biochemistry, and electrolyte tests were conducted to evaluate acute oral toxicity. Propolis was administered at a 5% concentration and 40 g dosage, and the beagles were monitored for 8 weeks. Three beagles served as controls, while four beagles each were assigned to the liquid and powder groups. No significant clinical signs or changes in feed intake, water consumption, body condition, or hematological/biochemical parameters were observed. The results indicate that oral administration of both liquid and powder propolis does not induce toxicological effects in beagle.

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References

  1. Ayad AS, Benchaabane S, Daas T, Smagghe G, LoucifAyad, W. 2024. Assessment of efficacy of Algerian propolis against the parasitic mite Varroa destructor and safety for honey bees by spray treatment. Insects 15(1): 75.
  2. Berretta AA, Zamarrenho LG, Correa JA, De Lima JA, Borini GB, Ambrosio SR, Barud HS, Bastos JK, De Jong D. 2023. Development and characterization of new green propolis extract formulations as promising candidates to substitute for green propolis hydroalcoholic extract. Molecules 28(8): 3510.
  3. Braakhuis A. 2019. Evidence on the health benefits of supplemental propolis. Nutrients 11(11): 2705.
  4. Devequi-Nunes D, Machado BAS, Barreto GA, Silva JR, Silva DF, Rocha JLC, Brandao HN, Borges VM, Umsza-Guez, MA. 2018. Chemical characterization and biological activity of six different extracts of propolis through conventional methods and supercritical extraction. PLoS One 13(12): e0207676.
  5. Glausiusz J. 2021. How dogs became humans' best friends: from Neanderthals to now. Nature 599(7886): 553-554.
  6. Kim J, Chun BC. 2021. Association between companion animal ownership and overall life satisfaction in Seoul, Korea. PLoS One 16(9): e0258034.
  7. Kim SK, Woo SO, Chang JS. 2021. Biological properties of propolis isolated from honeybees. J Life Sci 31(7): 686-697.
  8. Kubiliene L, Laugaliene V, Pavilonis A, Maruska A, Majiene D, Barcauskaite K, Kubilius R, Kasparaviciene G, Savickas A. 2015. Alternative preparation of propolis extracts: Comparison of their composition and biological activities. BMC Complement Altern Med 15: 156.
  9. Marcial-Modesto D, Chin BN, Casserly ED, Parsons SM, Feeney BC. 2023. Pet ownership and mental health in United States adults during COVID-19. Front Psychol 14: 1217059.
  10. Ripari N, Sartori AA, Honorio MS, Conte FL, Tasca KI, Santiago KB, Sforcin JM. 2021. Propolis antiviral and immunomodulatory activity: A review and perspectives for COVID-19 treatment. J Pharm Pharmacol 73(3): 281-299.
  11. Siheri W, Alenezi S, Tusiimire J, Watson DG. 2017. The chemical and biological properties of propolis. In J. Alvarez-Suarez (Ed.), Bee products - Chemical and biological properties (pp. 137-178). Springer, Cham.
  12. Svetikiene D, Zamokas G, Jokubaite M, Marksa M, Ivanauskas L, Babickaite L, Ramanauskiene K. 2024. The comparative study of the antioxidant and antibacterial effects of propolis extracts in veterinary medicine. Vet Sci 11(8): 375.